| Name | TGFBR1 |
| ID | P36897 |
| Role | kinase |
| Enzymatic Domains |
GS 175-204 PROSITE-ProRule
Protein kinase 205-495 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TGFBR1 | SHC1 | – | phosphorylation up-regulates | 17673906 | SIGNOR-227503 | |
| TGFBR1 | EEF1A1 | Ser300 | EMHHEALsEALPGDN | phosphorylation down-regulates | 20832312 | SIGNOR-167943 |
| TGFBR1 | SMAD3 | Ser423 | SPSIRCSsVS | phosphorylation up-regulates activity | 19458083 | SIGNOR-235385 |
| TGFBR1 | SMAD3 | Ser425 | SIRCSSVs | phosphorylation up-regulates activity | 19458083 | SIGNOR-235380 |
| TGFBR1 | SMAD3 | – | phosphorylation up-regulates activity | 19701891 | SIGNOR-254361 | |
| TGFBR1 | SPTBN1 | – | phosphorylation up-regulates | 12543979 | SIGNOR-97626 | |
| TGFBR1 | ACVR1 | – | phosphorylation up-regulates activity | 29376829 | SIGNOR-279490 | |
| TGFBR1 | SMAD2 | – | phosphorylation up-regulates activity | 10973958 | SIGNOR-249549 | |
| TGFBR1 | SMAD2 | Ser465 | SPSVRCSsMS | phosphorylation up-regulates activity | 9346908 | SIGNOR-236107 |
| TGFBR1 | SMAD2 | Ser467 | SVRCSSMs | phosphorylation up-regulates activity | 9346908 | SIGNOR-235995 |
| TGFBR1 | TP63 | Ser160 | SSTFDALsPSPAIPS | phosphorylation unknown | 23166821 | SIGNOR-199781 |
| TGFBR1 | TP63 | Ser68 | FLEQPICsVQPIDLN | phosphorylation unknown | 23166821 | SIGNOR-199785 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TGFBR1 | phosphorylation up-regulates → | EEF1A1 PSer300 | phosphorylation down-regulates ⊣ | EEF1A1 | 20832312 | SIGNOR-167943 |
| TGFBR1 | phosphorylation up-regulates → | SMAD3 PSer423 | phosphorylation up-regulates → | SMAD3 | 19458083 | SIGNOR-235385 |
| TGFBR1 | phosphorylation up-regulates → | SMAD3 PSer425 | phosphorylation up-regulates → | SMAD3 | 19458083 | SIGNOR-235380 |
| TGFBR1 | phosphorylation up-regulates → | SMAD2 PSer465 | phosphorylation up-regulates → | SMAD2 | 9346908 | SIGNOR-236107 |
| TGFBR1 | phosphorylation up-regulates → | SMAD2 PSer467 | phosphorylation up-regulates → | SMAD2 | 9346908 | SIGNOR-235995 |
| TGFBR1 | phosphorylation up-regulates → | TP63 PSer160 | phosphorylation down-regulates ⊣ | TP63 | 23166821 | SIGNOR-199781 |
| TGFBR1 | phosphorylation up-regulates → | TP63 PSer68 | phosphorylation down-regulates ⊣ | TP63 | 23166821 | SIGNOR-199785 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| TGFBR1 | phosphorylation → up-regulates | SHC1 | SIGNOR-227503 |
| TGFBR1 | phosphorylation down-regulates | EEF1A1 | SIGNOR-167943 |
| TGFBR1 | phosphorylation → up-regulates activity | SMAD3 | SIGNOR-235385 |
| TGFBR1 | phosphorylation → up-regulates activity | SMAD3 | SIGNOR-235380 |
| TGFBR1 | phosphorylation → up-regulates activity | SMAD3 | SIGNOR-254361 |
| TGFBR1 | phosphorylation → up-regulates | SPTBN1 | SIGNOR-97626 |
| TGFBR1 | phosphorylation → up-regulates activity | ACVR1 | SIGNOR-279490 |
| TGFBR1 | phosphorylation → up-regulates activity | SMAD2 | SIGNOR-249549 |
| TGFBR1 | phosphorylation → up-regulates activity | SMAD2 | SIGNOR-236107 |
| TGFBR1 | phosphorylation → up-regulates activity | SMAD2 | SIGNOR-235995 |
| TGFBR1 | phosphorylation → unknown | TP63 | SIGNOR-199781 |
| TGFBR1 | phosphorylation → unknown | TP63 | SIGNOR-199785 |