| Name | TGFBR1 |
| ID | P36897 |
| Role | substrate |
| Enzymatic Domains |
GS 175-204 PROSITE-ProRule
Protein kinase 205-495 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TGFBR2 | TGFBR1 | Thr200 | LPLLVQRtIARTIVL | phosphorylation up-regulates activity | 7774578 | SIGNOR-32744 |
| TGFBR2 | TGFBR1 | – | phosphorylation up-regulates | 26194464 | SIGNOR-255032 | |
| TGFBR2 | TGFBR1 | Thr176 | PFISEGTtLKDLIYD | phosphorylation up-regulates activity | 8576253 | SIGNOR-255961 |
| PPP1CC | TGFBR1 | – | dephosphorylation down-regulates | 14718519 | SIGNOR-121277 | |
| TGFBR2 | TGFBR1 | Ser172 | SLDRPFIsEGTTLKD | phosphorylation up-regulates activity | 8576253 | SIGNOR-246728 |
| TGFBR2 | TGFBR1 | Thr204 | VQRTIARtIVLQESI | phosphorylation up-regulates activity | 7774578 | SIGNOR-32748 |
| TGFBR2 | TGFBR1 | Thr200 | LPLLVQRtIARTIVL | phosphorylation up-regulates activity | 8576253 | SIGNOR-255962 |
| TGFBR2 | TGFBR1 | Thr176 | PFISEGTtLKDLIYD | phosphorylation up-regulates activity | 8576253 | SIGNOR-246732 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TGFBR2 | phosphorylation up-regulates → | TGFBR1 PThr200 | phosphorylation up-regulates → | TGFBR1 | 7774578 | SIGNOR-32744 |
| TGFBR2 | phosphorylation up-regulates → | TGFBR1 PThr176 | phosphorylation up-regulates → | TGFBR1 | 8576253 | SIGNOR-255961 |
| TGFBR2 | phosphorylation up-regulates → | TGFBR1 PSer172 | phosphorylation up-regulates → | TGFBR1 | 8576253 | SIGNOR-246728 |
| TGFBR2 | phosphorylation up-regulates → | TGFBR1 PThr204 | phosphorylation up-regulates → | TGFBR1 | 7774578 | SIGNOR-32748 |
| TGFBR2 | phosphorylation up-regulates → | TGFBR1 PThr200 | phosphorylation up-regulates → | TGFBR1 | 8576253 | SIGNOR-255962 |
| TGFBR2 | phosphorylation up-regulates → | TGFBR1 PThr176 | phosphorylation up-regulates → | TGFBR1 | 8576253 | SIGNOR-246732 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| TGFBR2 | phosphorylation → up-regulates activity | TGFBR1 | SIGNOR-32744 |
| TGFBR2 | phosphorylation → up-regulates | TGFBR1 | SIGNOR-255032 |
| TGFBR2 | phosphorylation → up-regulates activity | TGFBR1 | SIGNOR-255961 |
| PPP1CC | dephosphorylation down-regulates | TGFBR1 | SIGNOR-121277 |
| TGFBR2 | phosphorylation → up-regulates activity | TGFBR1 | SIGNOR-246728 |
| TGFBR2 | phosphorylation → up-regulates activity | TGFBR1 | SIGNOR-32748 |
| TGFBR2 | phosphorylation → up-regulates activity | TGFBR1 | SIGNOR-255962 |
| TGFBR2 | phosphorylation → up-regulates activity | TGFBR1 | SIGNOR-246732 |