| Name | PPARG |
| ID | P37231 |
| Role | substrate |
| Enzymatic Domains |
NR LBD 238-503 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1B | PPARG | – | dephosphorylation up-regulates activity | 23320500 | SIGNOR-277073 | |
| CDK5 | PPARG | Ser273 | TGKTTDKsPFVIYDM | phosphorylation down-regulates activity | 25827822 | SIGNOR-278189 |
| BCR | PPARG | Ser112 | AIKVEPAsPPYYSEK | phosphorylation down-regulates activity | 19023129 | SIGNOR-279441 |
| MAPK3 | PPARG | Ser112 | AIKVEPAsPPYYSEK | phosphorylation down-regulates quantity by destabilization | 11733495 | SIGNOR-179404 |
| ERK1/2 | PPARG | Ser112 | AIKVEPAsPPYYSEK | phosphorylation up-regulates activity | 11733495 | SIGNOR-232236 |
| ABL1 | PPARG | Tyr102 | YDLKLQEyQSAIKVE | phosphorylation up-regulates quantity | 25368164 | SIGNOR-262297 |
| MAPK1 | PPARG | – | phosphorylation down-regulates | 18596912 | SIGNOR-210182 | |
| MAPK8 | PPARG | Ser112 | AIKVEPAsPPYYSEK | phosphorylation down-regulates activity | 9030579 | SIGNOR-46518 |
| EGFR | PPARG | Tyr102 | YDLKLQEyQSAIKVE | phosphorylation down-regulates quantity by destabilization | 26718225 | SIGNOR-277190 |
| ERK1/2 | PPARG | – | phosphorylation up-regulates quantity by expression | 12270934 | SIGNOR-235334 | |
| MAPK1 | PPARG | Ser112 | AIKVEPAsPPYYSEK | phosphorylation down-regulates quantity by destabilization | 11733495 | SIGNOR-112544 |
| ABL1 | PPARG | Tyr78 | SSISTPHyEDIPFTR | phosphorylation up-regulates quantity | 25368164 | SIGNOR-255912 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK5 | phosphorylation up-regulates → | PPARG PSer273 | phosphorylation down-regulates ⊣ | PPARG | 25827822 | SIGNOR-278189 |
| BCR | phosphorylation up-regulates → | PPARG PSer112 | phosphorylation down-regulates ⊣ | PPARG | 19023129 | SIGNOR-279441 |
| MAPK3 | phosphorylation up-regulates → | PPARG PSer112 | phosphorylation down-regulates ⊣ | PPARG | 11733495 | SIGNOR-179404 |
| ERK1/2 | phosphorylation up-regulates → | PPARG PSer112 | phosphorylation up-regulates → | PPARG | 11733495 | SIGNOR-232236 |
| ABL1 | phosphorylation up-regulates → | PPARG PTyr102 | phosphorylation up-regulates → | PPARG | 25368164 | SIGNOR-262297 |
| MAPK8 | phosphorylation up-regulates → | PPARG PSer112 | phosphorylation down-regulates ⊣ | PPARG | 9030579 | SIGNOR-46518 |
| EGFR | phosphorylation up-regulates → | PPARG PTyr102 | phosphorylation down-regulates ⊣ | PPARG | 26718225 | SIGNOR-277190 |
| MAPK1 | phosphorylation up-regulates → | PPARG PSer112 | phosphorylation down-regulates ⊣ | PPARG | 11733495 | SIGNOR-112544 |
| ABL1 | phosphorylation up-regulates → | PPARG PTyr78 | phosphorylation up-regulates → | PPARG | 25368164 | SIGNOR-255912 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPM1B | dephosphorylation → up-regulates activity | PPARG | SIGNOR-277073 |
| CDK5 | phosphorylation → down-regulates activity | PPARG | SIGNOR-278189 |
| BCR | phosphorylation → down-regulates activity | PPARG | SIGNOR-279441 |
| MAPK3 | phosphorylation down-regulates quantity by destabilization | PPARG | SIGNOR-179404 |
| ERK1/2 | phosphorylation → up-regulates activity | PPARG | SIGNOR-232236 |
| ABL1 | phosphorylation → up-regulates quantity | PPARG | SIGNOR-262297 |
| MAPK1 | phosphorylation down-regulates | PPARG | SIGNOR-210182 |
| MAPK8 | phosphorylation → down-regulates activity | PPARG | SIGNOR-46518 |
| EGFR | phosphorylation down-regulates quantity by destabilization | PPARG | SIGNOR-277190 |
| ERK1/2 | phosphorylation → up-regulates quantity by expression | PPARG | SIGNOR-235334 |
| MAPK1 | phosphorylation down-regulates quantity by destabilization | PPARG | SIGNOR-112544 |
| ABL1 | phosphorylation → up-regulates quantity | PPARG | SIGNOR-255912 |