| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | SNCA | Ser87 | KTVEGAGsIAAATGF | phosphorylation up-regulates | 10617630 | SIGNOR-73807 |
| GRK5 | SNCA | Ser129 | NEAYEMPsEEGYQDY | phosphorylation down-regulates activity | 16957079 | SIGNOR-149372 |
| PPP2CB | SNCA | Ser129 | NEAYEMPsEEGYQDY | dephosphorylation down-regulates activity | 21562258 | SIGNOR-248592 |
| GRK2 | SNCA | Ser129 | NEAYEMPsEEGYQDY | phosphorylation down-regulates activity | 10852916 | SIGNOR-78333 |
| DAPK1 | SNCA | Ser129 | NEAYEMPsEEGYQDY | phosphorylation up-regulates quantity | 32624505 | SIGNOR-278440 |
| CSNK2A1 | SNCA | Ser129 | NEAYEMPsEEGYQDY | phosphorylation down-regulates activity | 10617630 | SIGNOR-73803 |
| DYRK1A | SNCA | Ser87 | KTVEGAGsIAAATGF | phosphorylation up-regulates | 16959772 | SIGNOR-149393 |
| SYK | SNCA | Tyr133 | EMPSEEGyQDYEPEA | phosphorylation down-regulates | 11744621 | SIGNOR-113065 |
| ABL1 | SNCA | Tyr39 | KTKEGVLyVGSKTKE | phosphorylation up-regulates quantity | 29103051 | SIGNOR-279582 |
| PLK1 | SNCA | Ser129 | NEAYEMPsEEGYQDY | phosphorylation down-regulates activity | 19889641 | SIGNOR-189045 |
| PLK2 | SNCA | Ser129 | NEAYEMPsEEGYQDY | phosphorylation down-regulates activity | 19889641 | SIGNOR-182155 |
| SYK | SNCA | Tyr136 | SEEGYQDyEPEA | phosphorylation down-regulates | 11744621 | SIGNOR-113069 |
| SYK | SNCA | Tyr125 | VDPDNEAyEMPSEEG | phosphorylation down-regulates | 11744621 | SIGNOR-113061 |
| CSNK1A1 | SNCA | Ser87 | KTVEGAGsIAAATGF | phosphorylation up-regulates | 10617630 | SIGNOR-73799 |
| CSNK1A1 | SNCA | Ser129 | NEAYEMPsEEGYQDY | phosphorylation down-regulates activity | 10617630 | SIGNOR-73795 |
| PLK3 | SNCA | Ser129 | NEAYEMPsEEGYQDY | phosphorylation down-regulates activity | 19889641 | SIGNOR-189053 |
| PTK2B | SNCA | Tyr125 | VDPDNEAyEMPSEEG | phosphorylation unknown | 12096713 | SIGNOR-249151 |
| LRRK2 | SNCA | Ser129 | NEAYEMPsEEGYQDY | phosphorylation down-regulates activity | 19576176 | SIGNOR-249690 |
| PPP2CA | SNCA | Ser129 | NEAYEMPsEEGYQDY | dephosphorylation down-regulates activity | 21562258 | SIGNOR-248635 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | phosphorylation up-regulates → | SNCA PSer87 | phosphorylation up-regulates → | SNCA | 10617630 | SIGNOR-73807 |
| GRK5 | phosphorylation up-regulates → | SNCA PSer129 | phosphorylation down-regulates ⊣ | SNCA | 16957079 | SIGNOR-149372 |
| PPP2CB | dephosphorylation down-regulates ⊣ | SNCA PSer129 | dephosphorylation up-regulates → | SNCA | 21562258 | SIGNOR-248592 |
| GRK2 | phosphorylation up-regulates → | SNCA PSer129 | phosphorylation down-regulates ⊣ | SNCA | 10852916 | SIGNOR-78333 |
| DAPK1 | phosphorylation up-regulates → | SNCA PSer129 | phosphorylation up-regulates → | SNCA | 32624505 | SIGNOR-278440 |
| CSNK2A1 | phosphorylation up-regulates → | SNCA PSer129 | phosphorylation down-regulates ⊣ | SNCA | 10617630 | SIGNOR-73803 |
| DYRK1A | phosphorylation up-regulates → | SNCA PSer87 | phosphorylation up-regulates → | SNCA | 16959772 | SIGNOR-149393 |
| SYK | phosphorylation up-regulates → | SNCA PTyr133 | phosphorylation down-regulates ⊣ | SNCA | 11744621 | SIGNOR-113065 |
| ABL1 | phosphorylation up-regulates → | SNCA PTyr39 | phosphorylation up-regulates → | SNCA | 29103051 | SIGNOR-279582 |
| PLK1 | phosphorylation up-regulates → | SNCA PSer129 | phosphorylation down-regulates ⊣ | SNCA | 19889641 | SIGNOR-189045 |
| PLK2 | phosphorylation up-regulates → | SNCA PSer129 | phosphorylation down-regulates ⊣ | SNCA | 19889641 | SIGNOR-182155 |
| SYK | phosphorylation up-regulates → | SNCA PTyr136 | phosphorylation down-regulates ⊣ | SNCA | 11744621 | SIGNOR-113069 |
| SYK | phosphorylation up-regulates → | SNCA PTyr125 | phosphorylation down-regulates ⊣ | SNCA | 11744621 | SIGNOR-113061 |
| CSNK1A1 | phosphorylation up-regulates → | SNCA PSer87 | phosphorylation up-regulates → | SNCA | 10617630 | SIGNOR-73799 |
| CSNK1A1 | phosphorylation up-regulates → | SNCA PSer129 | phosphorylation down-regulates ⊣ | SNCA | 10617630 | SIGNOR-73795 |
| PLK3 | phosphorylation up-regulates → | SNCA PSer129 | phosphorylation down-regulates ⊣ | SNCA | 19889641 | SIGNOR-189053 |
| PTK2B | phosphorylation up-regulates → | SNCA PTyr125 | phosphorylation down-regulates ⊣ | SNCA | 12096713 | SIGNOR-249151 |
| LRRK2 | phosphorylation up-regulates → | SNCA PSer129 | phosphorylation down-regulates ⊣ | SNCA | 19576176 | SIGNOR-249690 |
| PPP2CA | dephosphorylation down-regulates ⊣ | SNCA PSer129 | dephosphorylation up-regulates → | SNCA | 21562258 | SIGNOR-248635 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK2A1 | phosphorylation → up-regulates | SNCA | SIGNOR-73807 |
| GRK5 | phosphorylation → down-regulates activity | SNCA | SIGNOR-149372 |
| PPP2CB | dephosphorylation → down-regulates activity | SNCA | SIGNOR-248592 |
| GRK2 | phosphorylation → down-regulates activity | SNCA | SIGNOR-78333 |
| DAPK1 | phosphorylation → up-regulates quantity | SNCA | SIGNOR-278440 |
| CSNK2A1 | phosphorylation → down-regulates activity | SNCA | SIGNOR-73803 |
| DYRK1A | phosphorylation → up-regulates | SNCA | SIGNOR-149393 |
| SYK | phosphorylation down-regulates | SNCA | SIGNOR-113065 |
| ABL1 | phosphorylation → up-regulates quantity | SNCA | SIGNOR-279582 |
| PLK1 | phosphorylation → down-regulates activity | SNCA | SIGNOR-189045 |
| PLK2 | phosphorylation → down-regulates activity | SNCA | SIGNOR-182155 |
| SYK | phosphorylation down-regulates | SNCA | SIGNOR-113069 |
| SYK | phosphorylation down-regulates | SNCA | SIGNOR-113061 |
| CSNK1A1 | phosphorylation → up-regulates | SNCA | SIGNOR-73799 |
| CSNK1A1 | phosphorylation → down-regulates activity | SNCA | SIGNOR-73795 |
| PLK3 | phosphorylation → down-regulates activity | SNCA | SIGNOR-189053 |
| PTK2B | phosphorylation → unknown | SNCA | SIGNOR-249151 |
| LRRK2 | phosphorylation → down-regulates activity | SNCA | SIGNOR-249690 |
| PPP2CA | dephosphorylation → down-regulates activity | SNCA | SIGNOR-248635 |
