| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GRK2 | SNCA | Ser129 | NEAYEMPsEEGYQDY | phosphorylation down-regulates activity | 10852916 | SIGNOR-78333 |
| DAPK1 | SNCA | Ser129 | NEAYEMPsEEGYQDY | phosphorylation up-regulates quantity | 32624505 | SIGNOR-278440 |
| CSNK2A1 | SNCA | Ser129 | NEAYEMPsEEGYQDY | phosphorylation down-regulates activity | 10617630 | SIGNOR-73803 |
| PLK1 | SNCA | Ser129 | NEAYEMPsEEGYQDY | phosphorylation down-regulates activity | 19889641 | SIGNOR-189045 |
| PLK2 | SNCA | Ser129 | NEAYEMPsEEGYQDY | phosphorylation down-regulates activity | 19889641 | SIGNOR-182155 |
| CSNK1A1 | SNCA | Ser129 | NEAYEMPsEEGYQDY | phosphorylation down-regulates activity | 10617630 | SIGNOR-73795 |
| PLK3 | SNCA | Ser129 | NEAYEMPsEEGYQDY | phosphorylation down-regulates activity | 19889641 | SIGNOR-189053 |
| LRRK2 | SNCA | Ser129 | NEAYEMPsEEGYQDY | phosphorylation down-regulates activity | 19576176 | SIGNOR-249690 |
| PPP2CA | SNCA | Ser129 | NEAYEMPsEEGYQDY | dephosphorylation down-regulates activity | 21562258 | SIGNOR-248635 |
| GRK5 | SNCA | Ser129 | NEAYEMPsEEGYQDY | phosphorylation down-regulates activity | 16957079 | SIGNOR-149372 |
| PPP2CB | SNCA | Ser129 | NEAYEMPsEEGYQDY | dephosphorylation down-regulates activity | 21562258 | SIGNOR-248592 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GRK2 | phosphorylation up-regulates → | SNCA PSer129 | phosphorylation down-regulates ⊣ | SNCA | 10852916 | SIGNOR-78333 |
| DAPK1 | phosphorylation up-regulates → | SNCA PSer129 | phosphorylation up-regulates → | SNCA | 32624505 | SIGNOR-278440 |
| CSNK2A1 | phosphorylation up-regulates → | SNCA PSer129 | phosphorylation down-regulates ⊣ | SNCA | 10617630 | SIGNOR-73803 |
| PLK1 | phosphorylation up-regulates → | SNCA PSer129 | phosphorylation down-regulates ⊣ | SNCA | 19889641 | SIGNOR-189045 |
| PLK2 | phosphorylation up-regulates → | SNCA PSer129 | phosphorylation down-regulates ⊣ | SNCA | 19889641 | SIGNOR-182155 |
| CSNK1A1 | phosphorylation up-regulates → | SNCA PSer129 | phosphorylation down-regulates ⊣ | SNCA | 10617630 | SIGNOR-73795 |
| PLK3 | phosphorylation up-regulates → | SNCA PSer129 | phosphorylation down-regulates ⊣ | SNCA | 19889641 | SIGNOR-189053 |
| LRRK2 | phosphorylation up-regulates → | SNCA PSer129 | phosphorylation down-regulates ⊣ | SNCA | 19576176 | SIGNOR-249690 |
| PPP2CA | dephosphorylation down-regulates ⊣ | SNCA PSer129 | dephosphorylation up-regulates → | SNCA | 21562258 | SIGNOR-248635 |
| GRK5 | phosphorylation up-regulates → | SNCA PSer129 | phosphorylation down-regulates ⊣ | SNCA | 16957079 | SIGNOR-149372 |
| PPP2CB | dephosphorylation down-regulates ⊣ | SNCA PSer129 | dephosphorylation up-regulates → | SNCA | 21562258 | SIGNOR-248592 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GRK2 | phosphorylation → down-regulates activity | SNCA | SIGNOR-78333 |
| DAPK1 | phosphorylation → up-regulates quantity | SNCA | SIGNOR-278440 |
| CSNK2A1 | phosphorylation → down-regulates activity | SNCA | SIGNOR-73803 |
| PLK1 | phosphorylation → down-regulates activity | SNCA | SIGNOR-189045 |
| PLK2 | phosphorylation → down-regulates activity | SNCA | SIGNOR-182155 |
| CSNK1A1 | phosphorylation → down-regulates activity | SNCA | SIGNOR-73795 |
| PLK3 | phosphorylation → down-regulates activity | SNCA | SIGNOR-189053 |
| LRRK2 | phosphorylation → down-regulates activity | SNCA | SIGNOR-249690 |
| PPP2CA | dephosphorylation → down-regulates activity | SNCA | SIGNOR-248635 |
| GRK5 | phosphorylation → down-regulates activity | SNCA | SIGNOR-149372 |
| PPP2CB | dephosphorylation → down-regulates activity | SNCA | SIGNOR-248592 |
