| Name | BRCA1 |
| ID | P38398 |
| Role | substrate |
| Enzymatic Domains |
BRCT 1 1642-1736 PROSITE-ProRule
BRCT 2 1756-1855 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATR | BRCA1 | – | phosphorylation up-regulates | 23422745 | SIGNOR-201050 | |
| CyclinD/CDK4 | BRCA1 | Ser632 | LVVSRNLsPPNCTEL | phosphorylation down-regulates | 17334399 | SIGNOR-216984 |
| ATR | BRCA1 | Ser1280 | QVILAKAsQEHHLSE | phosphorylation up-regulates activity | 11114888 | SIGNOR-250582 |
| ATR | BRCA1 | Ser1387 | EDCSGLSsQSDILTT | phosphorylation up-regulates activity | 11278964 | SIGNOR-106432 |
| CDK1 | BRCA1 | Ser1497 | EPGVERSsPSKCPSL | phosphorylation up-regulates | 10550055 | SIGNOR-72087 |
| ATM | BRCA1 | Ser1524 | LQNRNYPsQEELIKV | phosphorylation up-regulates | 10550055 | SIGNOR-72068 |
| FRK | BRCA1 | Tyr1552 | HDLTETSyLPRQDLE | phosphorylation up-regulates quantity by stabilization | 29156836 | SIGNOR-275454 |
| CSNK2A1 | BRCA1 | Ser1572 | ESGISLFsDDPESDP | phosphorylation unknown | 10403822 | SIGNOR-250832 |
| CDK1 | BRCA1 | Ser1189 | QKGELSRsPSPFTHT | phosphorylation up-regulates | 19683496 | SIGNOR-187595 |
| ATM | BRCA1 | Ser1524 | LQNRNYPsQEELIKV | phosphorylation unknown | 10550055 | SIGNOR-72079 |
| AKT | BRCA1 | Ser694 | QTSKRHDsDTFPELK | phosphorylation up-regulates | 20085797 | SIGNOR-244164 |
| ATR | BRCA1 | Ser1423 | AVLEQHGsQPSNSYP | phosphorylation up-regulates activity | 11278964 | SIGNOR-106436 |
| CDK1 | BRCA1 | Ser1189 | QKGELSRsPSPFTHT | phosphorylation up-regulates | 10550055 | SIGNOR-72083 |
| CSNK2B | BRCA1 | Ser1572 | ESGISLFsDDPESDP | phosphorylation unknown | 10403822 | SIGNOR-251055 |
| PPP1CA | BRCA1 | Ser988 | PPLFPIKsFVKTKCK | dephosphorylation down-regulates activity | 17603999 | SIGNOR-248560 |
| AKT1 | BRCA1 | Ser694 | QTSKRHDsDTFPELK | phosphorylation up-regulates | 20085797 | SIGNOR-163472 |
| ATM | BRCA1 | Ser1423 | AVLEQHGsQPSNSYP | phosphorylation up-regulates | 10550055 | SIGNOR-72052 |
| ATM | BRCA1 | Ser1497 | EPGVERSsPSKCPSL | phosphorylation up-regulates | 10550055 | SIGNOR-72064 |
| CHEK2 | BRCA1 | Ser988 | PPLFPIKsFVKTKCK | phosphorylation up-regulates | 14701743 | SIGNOR-120575 |
| ATM | BRCA1 | Ser1542 | EEQQLEEsGPHDLTE | phosphorylation up-regulates | 10550055 | SIGNOR-72072 |
| ATM | BRCA1 | Ser1330 | QMRHQSEsQGVGLSD | phosphorylation up-regulates | 10550055 | SIGNOR-72048 |
| ATM | BRCA1 | Ser1497 | EPGVERSsPSKCPSL | phosphorylation up-regulates | 19683496 | SIGNOR-187591 |
| ATM | BRCA1 | – | phosphorylation up-regulates | 10550055 | SIGNOR-72075 | |
| ATR | BRCA1 | Thr1394 | SQSDILTtQQRDTMQ | phosphorylation up-regulates activity | 11114888 | SIGNOR-250583 |
| ATR | BRCA1 | Ser1457 | SEKAVLTsQKSSEYP | phosphorylation up-regulates activity | 11278964 | SIGNOR-106440 |
| CDK2 | BRCA1 | Ser1497 | EPGVERSsPSKCPSL | phosphorylation up-regulates | 19683496 | SIGNOR-187607 |
| ATM | BRCA1 | – | phosphorylation up-regulates | 12024016 | SIGNOR-87845 | |
| PPP1CA | BRCA1 | Ser1423 | AVLEQHGsQPSNSYP | dephosphorylation down-regulates activity | 17603999 | SIGNOR-248561 |
| PPP1CA | BRCA1 | Ser1524 | LQNRNYPsQEELIKV | dephosphorylation down-regulates activity | 17603999 | SIGNOR-248562 |
| CDK1 | BRCA1 | Ser1497 | EPGVERSsPSKCPSL | phosphorylation up-regulates | 19683496 | SIGNOR-187603 |
| CDK2 | BRCA1 | Ser1497 | EPGVERSsPSKCPSL | phosphorylation up-regulates | 10550055 | SIGNOR-72091 |
| AURKA | BRCA1 | Ser308 | KAEFCNKsKQPGLAR | phosphorylation up-regulates | 14990569 | SIGNOR-123065 |
| AKT | BRCA1 | Thr509 | LKRKRRPtSGLHPED | phosphorylation up-regulates | 17428466 | SIGNOR-244168 |
| ATM | BRCA1 | Ser1387 | EDCSGLSsQSDILTT | phosphorylation up-regulates | 12183412 | SIGNOR-91482 |
| ATM | BRCA1 | Ser1457 | SEKAVLTsQKSSEYP | phosphorylation up-regulates | 10550055 | SIGNOR-72056 |
| ATM | BRCA1 | Ser1466 | KSSEYPIsQNPEGLS | phosphorylation up-regulates | 10550055 | SIGNOR-72060 |
| AKT1 | BRCA1 | Thr509 | LKRKRRPtSGLHPED | phosphorylation up-regulates | 17428466 | SIGNOR-154312 |
| ATR | BRCA1 | Ser1143 | PMGSSHAsQVCSETP | phosphorylation up-regulates activity | 11114888 | SIGNOR-250581 |
| CDK4 | BRCA1 | Ser632 | LVVSRNLsPPNCTEL | phosphorylation down-regulates | 17334399 | SIGNOR-153450 |
| CDK1 | BRCA1 | Ser1191 | GELSRSPsPFTHTHL | phosphorylation up-regulates | 19683496 | SIGNOR-187599 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinD/CDK4 | phosphorylation up-regulates → | BRCA1 PSer632 | phosphorylation down-regulates ⊣ | BRCA1 | 17334399 | SIGNOR-216984 |
| ATR | phosphorylation up-regulates → | BRCA1 PSer1280 | phosphorylation up-regulates → | BRCA1 | 11114888 | SIGNOR-250582 |
| ATR | phosphorylation up-regulates → | BRCA1 PSer1387 | phosphorylation up-regulates → | BRCA1 | 11278964 | SIGNOR-106432 |
| CDK1 | phosphorylation up-regulates → | BRCA1 PSer1497 | phosphorylation up-regulates → | BRCA1 | 10550055 | SIGNOR-72087 |
| ATM | phosphorylation up-regulates → | BRCA1 PSer1524 | phosphorylation up-regulates → | BRCA1 | 10550055 | SIGNOR-72068 |
| FRK | phosphorylation up-regulates → | BRCA1 PTyr1552 | phosphorylation up-regulates → | BRCA1 | 29156836 | SIGNOR-275454 |
| CSNK2A1 | phosphorylation up-regulates → | BRCA1 PSer1572 | phosphorylation down-regulates ⊣ | BRCA1 | 10403822 | SIGNOR-250832 |
| CDK1 | phosphorylation up-regulates → | BRCA1 PSer1189 | phosphorylation up-regulates → | BRCA1 | 19683496 | SIGNOR-187595 |
| ATM | phosphorylation up-regulates → | BRCA1 PSer1524 | phosphorylation down-regulates ⊣ | BRCA1 | 10550055 | SIGNOR-72079 |
| AKT | phosphorylation up-regulates → | BRCA1 PSer694 | phosphorylation up-regulates → | BRCA1 | 20085797 | SIGNOR-244164 |
| ATR | phosphorylation up-regulates → | BRCA1 PSer1423 | phosphorylation up-regulates → | BRCA1 | 11278964 | SIGNOR-106436 |
| CDK1 | phosphorylation up-regulates → | BRCA1 PSer1189 | phosphorylation up-regulates → | BRCA1 | 10550055 | SIGNOR-72083 |
| CSNK2B | phosphorylation up-regulates → | BRCA1 PSer1572 | phosphorylation down-regulates ⊣ | BRCA1 | 10403822 | SIGNOR-251055 |
| PPP1CA | dephosphorylation down-regulates ⊣ | BRCA1 PSer988 | dephosphorylation up-regulates → | BRCA1 | 17603999 | SIGNOR-248560 |
| AKT1 | phosphorylation up-regulates → | BRCA1 PSer694 | phosphorylation up-regulates → | BRCA1 | 20085797 | SIGNOR-163472 |
| ATM | phosphorylation up-regulates → | BRCA1 PSer1423 | phosphorylation up-regulates → | BRCA1 | 10550055 | SIGNOR-72052 |
| ATM | phosphorylation up-regulates → | BRCA1 PSer1497 | phosphorylation up-regulates → | BRCA1 | 10550055 | SIGNOR-72064 |
| CHEK2 | phosphorylation up-regulates → | BRCA1 PSer988 | phosphorylation up-regulates → | BRCA1 | 14701743 | SIGNOR-120575 |
| ATM | phosphorylation up-regulates → | BRCA1 PSer1542 | phosphorylation up-regulates → | BRCA1 | 10550055 | SIGNOR-72072 |
| ATM | phosphorylation up-regulates → | BRCA1 PSer1330 | phosphorylation up-regulates → | BRCA1 | 10550055 | SIGNOR-72048 |
| ATM | phosphorylation up-regulates → | BRCA1 PSer1497 | phosphorylation up-regulates → | BRCA1 | 19683496 | SIGNOR-187591 |
| ATR | phosphorylation up-regulates → | BRCA1 PThr1394 | phosphorylation up-regulates → | BRCA1 | 11114888 | SIGNOR-250583 |
| ATR | phosphorylation up-regulates → | BRCA1 PSer1457 | phosphorylation up-regulates → | BRCA1 | 11278964 | SIGNOR-106440 |
| CDK2 | phosphorylation up-regulates → | BRCA1 PSer1497 | phosphorylation up-regulates → | BRCA1 | 19683496 | SIGNOR-187607 |
| PPP1CA | dephosphorylation down-regulates ⊣ | BRCA1 PSer1423 | dephosphorylation up-regulates → | BRCA1 | 17603999 | SIGNOR-248561 |
| PPP1CA | dephosphorylation down-regulates ⊣ | BRCA1 PSer1524 | dephosphorylation up-regulates → | BRCA1 | 17603999 | SIGNOR-248562 |
| CDK1 | phosphorylation up-regulates → | BRCA1 PSer1497 | phosphorylation up-regulates → | BRCA1 | 19683496 | SIGNOR-187603 |
| CDK2 | phosphorylation up-regulates → | BRCA1 PSer1497 | phosphorylation up-regulates → | BRCA1 | 10550055 | SIGNOR-72091 |
| AURKA | phosphorylation up-regulates → | BRCA1 PSer308 | phosphorylation up-regulates → | BRCA1 | 14990569 | SIGNOR-123065 |
| AKT | phosphorylation up-regulates → | BRCA1 PThr509 | phosphorylation up-regulates → | BRCA1 | 17428466 | SIGNOR-244168 |
| ATM | phosphorylation up-regulates → | BRCA1 PSer1387 | phosphorylation up-regulates → | BRCA1 | 12183412 | SIGNOR-91482 |
| ATM | phosphorylation up-regulates → | BRCA1 PSer1457 | phosphorylation up-regulates → | BRCA1 | 10550055 | SIGNOR-72056 |
| ATM | phosphorylation up-regulates → | BRCA1 PSer1466 | phosphorylation up-regulates → | BRCA1 | 10550055 | SIGNOR-72060 |
| AKT1 | phosphorylation up-regulates → | BRCA1 PThr509 | phosphorylation up-regulates → | BRCA1 | 17428466 | SIGNOR-154312 |
| ATR | phosphorylation up-regulates → | BRCA1 PSer1143 | phosphorylation up-regulates → | BRCA1 | 11114888 | SIGNOR-250581 |
| CDK4 | phosphorylation up-regulates → | BRCA1 PSer632 | phosphorylation down-regulates ⊣ | BRCA1 | 17334399 | SIGNOR-153450 |
| CDK1 | phosphorylation up-regulates → | BRCA1 PSer1191 | phosphorylation up-regulates → | BRCA1 | 19683496 | SIGNOR-187599 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ATR | phosphorylation → up-regulates | BRCA1 | SIGNOR-201050 |
| CyclinD/CDK4 | phosphorylation down-regulates | BRCA1 | SIGNOR-216984 |
| ATR | phosphorylation → up-regulates activity | BRCA1 | SIGNOR-250582 |
| ATR | phosphorylation → up-regulates activity | BRCA1 | SIGNOR-106432 |
| CDK1 | phosphorylation → up-regulates | BRCA1 | SIGNOR-72087 |
| ATM | phosphorylation → up-regulates | BRCA1 | SIGNOR-72068 |
| FRK | phosphorylation → up-regulates quantity by stabilization | BRCA1 | SIGNOR-275454 |
| CSNK2A1 | phosphorylation → unknown | BRCA1 | SIGNOR-250832 |
| CDK1 | phosphorylation → up-regulates | BRCA1 | SIGNOR-187595 |
| ATM | phosphorylation → unknown | BRCA1 | SIGNOR-72079 |
| AKT | phosphorylation → up-regulates | BRCA1 | SIGNOR-244164 |
| ATR | phosphorylation → up-regulates activity | BRCA1 | SIGNOR-106436 |
| CDK1 | phosphorylation → up-regulates | BRCA1 | SIGNOR-72083 |
| CSNK2B | phosphorylation → unknown | BRCA1 | SIGNOR-251055 |
| PPP1CA | dephosphorylation → down-regulates activity | BRCA1 | SIGNOR-248560 |
| AKT1 | phosphorylation → up-regulates | BRCA1 | SIGNOR-163472 |
| ATM | phosphorylation → up-regulates | BRCA1 | SIGNOR-72052 |
| ATM | phosphorylation → up-regulates | BRCA1 | SIGNOR-72064 |
| CHEK2 | phosphorylation → up-regulates | BRCA1 | SIGNOR-120575 |
| ATM | phosphorylation → up-regulates | BRCA1 | SIGNOR-72072 |
| ATM | phosphorylation → up-regulates | BRCA1 | SIGNOR-72048 |
| ATM | phosphorylation → up-regulates | BRCA1 | SIGNOR-187591 |
| ATM | phosphorylation → up-regulates | BRCA1 | SIGNOR-72075 |
| ATR | phosphorylation → up-regulates activity | BRCA1 | SIGNOR-250583 |
| ATR | phosphorylation → up-regulates activity | BRCA1 | SIGNOR-106440 |
| CDK2 | phosphorylation → up-regulates | BRCA1 | SIGNOR-187607 |
| ATM | phosphorylation → up-regulates | BRCA1 | SIGNOR-87845 |
| PPP1CA | dephosphorylation → down-regulates activity | BRCA1 | SIGNOR-248561 |
| PPP1CA | dephosphorylation → down-regulates activity | BRCA1 | SIGNOR-248562 |
| CDK1 | phosphorylation → up-regulates | BRCA1 | SIGNOR-187603 |
| CDK2 | phosphorylation → up-regulates | BRCA1 | SIGNOR-72091 |
| AURKA | phosphorylation → up-regulates | BRCA1 | SIGNOR-123065 |
| AKT | phosphorylation → up-regulates | BRCA1 | SIGNOR-244168 |
| ATM | phosphorylation → up-regulates | BRCA1 | SIGNOR-91482 |
| ATM | phosphorylation → up-regulates | BRCA1 | SIGNOR-72056 |
| ATM | phosphorylation → up-regulates | BRCA1 | SIGNOR-72060 |
| AKT1 | phosphorylation → up-regulates | BRCA1 | SIGNOR-154312 |
| ATR | phosphorylation → up-regulates activity | BRCA1 | SIGNOR-250581 |
| CDK4 | phosphorylation down-regulates | BRCA1 | SIGNOR-153450 |
| CDK1 | phosphorylation → up-regulates | BRCA1 | SIGNOR-187599 |