| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP1CA | BRCA1 | Ser1423 | AVLEQHGsQPSNSYP | dephosphorylation down-regulates activity | 17603999 | SIGNOR-248561 |
| ATR | BRCA1 | Ser1423 | AVLEQHGsQPSNSYP | phosphorylation up-regulates activity | 11278964 | SIGNOR-106436 |
| ATM | BRCA1 | Ser1423 | AVLEQHGsQPSNSYP | phosphorylation up-regulates | 10550055 | SIGNOR-72052 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP1CA | dephosphorylation down-regulates ⊣ | BRCA1 PSer1423 | dephosphorylation up-regulates → | BRCA1 | 17603999 | SIGNOR-248561 |
| ATR | phosphorylation up-regulates → | BRCA1 PSer1423 | phosphorylation up-regulates → | BRCA1 | 11278964 | SIGNOR-106436 |
| ATM | phosphorylation up-regulates → | BRCA1 PSer1423 | phosphorylation up-regulates → | BRCA1 | 10550055 | SIGNOR-72052 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP1CA | dephosphorylation → down-regulates activity | BRCA1 | SIGNOR-248561 |
| ATR | phosphorylation → up-regulates activity | BRCA1 | SIGNOR-106436 |
| ATM | phosphorylation → up-regulates | BRCA1 | SIGNOR-72052 |
