Entity Details

Name	BRCA1_Ser1457
ID	P38398
Role	residue
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Data Summary

PTM Format

SIGNOR Summary

Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
ATM	BRCA1	Ser1457 View in OncoXplorer	SEKAVLTsQKSSEYP	phosphorylation up-regulates	10550055	SIGNOR-72056
ATR	BRCA1	Ser1457 View in OncoXplorer	SEKAVLTsQKSSEYP	phosphorylation up-regulates activity	11278964	SIGNOR-106440

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
ATM	phosphorylation up-regulates →	BRCA1 PSer1457	phosphorylation up-regulates →	BRCA1	10550055	SIGNOR-72056
ATR	phosphorylation up-regulates →	BRCA1 PSer1457	phosphorylation up-regulates →	BRCA1	11278964	SIGNOR-106440

Regulator	Mechanism/Effect	Target	SIGNOR-ID
ATM	phosphorylation → up-regulates	BRCA1	SIGNOR-72056
ATR	phosphorylation → up-regulates activity	BRCA1	SIGNOR-106440