| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK2 | BRCA1 | Ser988 | PPLFPIKsFVKTKCK | phosphorylation up-regulates | 14701743 | SIGNOR-120575 |
| PPP1CA | BRCA1 | Ser988 | PPLFPIKsFVKTKCK | dephosphorylation down-regulates activity | 17603999 | SIGNOR-248560 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK2 | phosphorylation up-regulates → | BRCA1 PSer988 | phosphorylation up-regulates → | BRCA1 | 14701743 | SIGNOR-120575 |
| PPP1CA | dephosphorylation down-regulates ⊣ | BRCA1 PSer988 | dephosphorylation up-regulates → | BRCA1 | 17603999 | SIGNOR-248560 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CHEK2 | phosphorylation → up-regulates | BRCA1 | SIGNOR-120575 |
| PPP1CA | dephosphorylation → down-regulates activity | BRCA1 | SIGNOR-248560 |
