| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK2 | BRCA1 | Ser1497 | EPGVERSsPSKCPSL | phosphorylation up-regulates | 10550055 | SIGNOR-72091 |
| ATM | BRCA1 | Ser1497 | EPGVERSsPSKCPSL | phosphorylation up-regulates | 19683496 | SIGNOR-187591 |
| ATM | BRCA1 | Ser1497 | EPGVERSsPSKCPSL | phosphorylation up-regulates | 10550055 | SIGNOR-72064 |
| CDK2 | BRCA1 | Ser1497 | EPGVERSsPSKCPSL | phosphorylation up-regulates | 19683496 | SIGNOR-187607 |
| CDK1 | BRCA1 | Ser1497 | EPGVERSsPSKCPSL | phosphorylation up-regulates | 10550055 | SIGNOR-72087 |
| CDK1 | BRCA1 | Ser1497 | EPGVERSsPSKCPSL | phosphorylation up-regulates | 19683496 | SIGNOR-187603 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK2 | phosphorylation up-regulates → | BRCA1 PSer1497 | phosphorylation up-regulates → | BRCA1 | 10550055 | SIGNOR-72091 |
| ATM | phosphorylation up-regulates → | BRCA1 PSer1497 | phosphorylation up-regulates → | BRCA1 | 19683496 | SIGNOR-187591 |
| ATM | phosphorylation up-regulates → | BRCA1 PSer1497 | phosphorylation up-regulates → | BRCA1 | 10550055 | SIGNOR-72064 |
| CDK2 | phosphorylation up-regulates → | BRCA1 PSer1497 | phosphorylation up-regulates → | BRCA1 | 19683496 | SIGNOR-187607 |
| CDK1 | phosphorylation up-regulates → | BRCA1 PSer1497 | phosphorylation up-regulates → | BRCA1 | 10550055 | SIGNOR-72087 |
| CDK1 | phosphorylation up-regulates → | BRCA1 PSer1497 | phosphorylation up-regulates → | BRCA1 | 19683496 | SIGNOR-187603 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK2 | phosphorylation → up-regulates | BRCA1 | SIGNOR-72091 |
| ATM | phosphorylation → up-regulates | BRCA1 | SIGNOR-187591 |
| ATM | phosphorylation → up-regulates | BRCA1 | SIGNOR-72064 |
| CDK2 | phosphorylation → up-regulates | BRCA1 | SIGNOR-187607 |
| CDK1 | phosphorylation → up-regulates | BRCA1 | SIGNOR-72087 |
| CDK1 | phosphorylation → up-regulates | BRCA1 | SIGNOR-187603 |
