| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK4 | BRCA1 | Ser632 | LVVSRNLsPPNCTEL | phosphorylation down-regulates | 17334399 | SIGNOR-153450 |
| CyclinD/CDK4 | BRCA1 | Ser632 | LVVSRNLsPPNCTEL | phosphorylation down-regulates | 17334399 | SIGNOR-216984 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK4 | phosphorylation up-regulates → | BRCA1 PSer632 | phosphorylation down-regulates ⊣ | BRCA1 | 17334399 | SIGNOR-153450 |
| CyclinD/CDK4 | phosphorylation up-regulates → | BRCA1 PSer632 | phosphorylation down-regulates ⊣ | BRCA1 | 17334399 | SIGNOR-216984 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK4 | phosphorylation![]() down-regulates | BRCA1 | SIGNOR-153450 |
| CyclinD/CDK4 | phosphorylation![]() down-regulates | BRCA1 | SIGNOR-216984 |