Entity Details

Name PPP1CA_Ser1423
ID P38398
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
ATMBRCA1Ser1423AVLEQHGsQPSNSYPphosphorylation
up-regulates		10550055SIGNOR-72052
ATRBRCA1Ser1423AVLEQHGsQPSNSYPphosphorylation
up-regulates activity		11278964SIGNOR-106436
PPP1CABRCA1Ser1423AVLEQHGsQPSNSYPdephosphorylation
down-regulates activity		17603999SIGNOR-248561
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
ATMphosphorylation
up-regulates
→
BRCA1
PSer1423		phosphorylation
up-regulates
→		BRCA110550055SIGNOR-72052
ATRphosphorylation
up-regulates
→
BRCA1
PSer1423		phosphorylation
up-regulates
→		BRCA111278964SIGNOR-106436
PPP1CAdephosphorylation
down-regulates
⊣
BRCA1
PSer1423		dephosphorylation
up-regulates
→		BRCA117603999SIGNOR-248561
Regulator Mechanism/Effect Target SIGNOR-ID
ATMphosphorylation
→
up-regulates 		BRCA1SIGNOR-72052
ATRphosphorylation
→
up-regulates activity 		BRCA1SIGNOR-106436
PPP1CAdephosphorylation
→
down-regulates activity 		BRCA1SIGNOR-248561