| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AURKA | VHL | – | phosphorylation down-regulates quantity by destabilization | 28114281 | SIGNOR-279800 | |
| NEK1 | VHL | Ser168 | RCLQVVRsLVKPENY | phosphorylation down-regulates quantity by destabilization | 23255108 | SIGNOR-276434 |
| CDK1 | VHL | Ser80 | QVIFCNRsPRVVLPV | phosphorylation down-regulates quantity by destabilization | 36813923 | SIGNOR-277836 |
| CHEK2 | VHL | Ser111 | GTGRRIHsYRGHLWL | phosphorylation up-regulates | 22071692 | SIGNOR-177091 |
| SRC | VHL | Tyr185 | LDIVRSLyEDLEDHP | phosphorylation down-regulates quantity by destabilization | 21212839 | SIGNOR-279125 |
| CDK1 | VHL | Ser80 | QVIFCNRsPRVVLPV | phosphorylation up-regulates activity | 36813923 | SIGNOR-280207 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| NEK1 | phosphorylation up-regulates → | VHL PSer168 | phosphorylation down-regulates ⊣ | VHL | 23255108 | SIGNOR-276434 |
| CDK1 | phosphorylation up-regulates → | VHL PSer80 | phosphorylation down-regulates ⊣ | VHL | 36813923 | SIGNOR-277836 |
| CHEK2 | phosphorylation up-regulates → | VHL PSer111 | phosphorylation up-regulates → | VHL | 22071692 | SIGNOR-177091 |
| SRC | phosphorylation up-regulates → | VHL PTyr185 | phosphorylation down-regulates ⊣ | VHL | 21212839 | SIGNOR-279125 |
| CDK1 | phosphorylation up-regulates → | VHL PSer80 | phosphorylation up-regulates → | VHL | 36813923 | SIGNOR-280207 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AURKA | phosphorylation down-regulates quantity by destabilization | VHL | SIGNOR-279800 |
| NEK1 | phosphorylation down-regulates quantity by destabilization | VHL | SIGNOR-276434 |
| CDK1 | phosphorylation down-regulates quantity by destabilization | VHL | SIGNOR-277836 |
| CHEK2 | phosphorylation → up-regulates | VHL | SIGNOR-177091 |
| SRC | phosphorylation down-regulates quantity by destabilization | VHL | SIGNOR-279125 |
| CDK1 | phosphorylation → up-regulates activity | VHL | SIGNOR-280207 |
