Entity Details

Name VHL
ID P40337
Role substrate
Enzymatic Domains
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CHEK2VHLSer111GTGRRIHsYRGHLWLphosphorylation
up-regulates		22071692SIGNOR-177091
NEK1VHLSer168RCLQVVRsLVKPENYphosphorylation
down-regulates quantity by destabilization		23255108SIGNOR-276434
CDK1VHLSer80QVIFCNRsPRVVLPVphosphorylation
down-regulates quantity by destabilization		36813923SIGNOR-277836
CDK1VHLSer80QVIFCNRsPRVVLPVphosphorylation
up-regulates activity		36813923SIGNOR-280207
SRCVHLTyr185LDIVRSLyEDLEDHPphosphorylation
down-regulates quantity by destabilization		21212839SIGNOR-279125
AURKAVHL–phosphorylation
down-regulates quantity by destabilization		28114281SIGNOR-279800
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CHEK2phosphorylation
up-regulates
→
VHL
PSer111		phosphorylation
up-regulates
→		VHL22071692SIGNOR-177091
NEK1phosphorylation
up-regulates
→
VHL
PSer168		phosphorylation
down-regulates
⊣		VHL23255108SIGNOR-276434
CDK1phosphorylation
up-regulates
→
VHL
PSer80		phosphorylation
down-regulates
⊣		VHL36813923SIGNOR-277836
CDK1phosphorylation
up-regulates
→
VHL
PSer80		phosphorylation
up-regulates
→		VHL36813923SIGNOR-280207
SRCphosphorylation
up-regulates
→
VHL
PTyr185		phosphorylation
down-regulates
⊣		VHL21212839SIGNOR-279125
Regulator Mechanism/Effect Target SIGNOR-ID
CHEK2phosphorylation
→
up-regulates 		VHLSIGNOR-177091
NEK1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		VHLSIGNOR-276434
CDK1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		VHLSIGNOR-277836
CDK1phosphorylation
→
up-regulates activity 		VHLSIGNOR-280207
SRCphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		VHLSIGNOR-279125
AURKAphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		VHLSIGNOR-279800