| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | VHL | Ser80 | QVIFCNRsPRVVLPV | phosphorylation down-regulates quantity by destabilization | 36813923 | SIGNOR-277836 |
| CDK1 | VHL | Ser80 | QVIFCNRsPRVVLPV | phosphorylation up-regulates activity | 36813923 | SIGNOR-280207 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | phosphorylation up-regulates → | VHL PSer80 | phosphorylation down-regulates ⊣ | VHL | 36813923 | SIGNOR-277836 |
| CDK1 | phosphorylation up-regulates → | VHL PSer80 | phosphorylation up-regulates → | VHL | 36813923 | SIGNOR-280207 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK1 | phosphorylation![]() down-regulates quantity by destabilization | VHL | SIGNOR-277836 |
| CDK1 | phosphorylation → up-regulates activity | VHL | SIGNOR-280207 |