Entity Details

Name USP8
ID P40818
Role substrate
Enzymatic Domains
MIT 33-116
Rhodanese 195-313
PROSITE-ProRule
USP 777-1109
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
EGFRUSP8Tyr810DYFNRNCyQDDINRSphosphorylation
up-regulates activity		29472535SIGNOR-279038
EGFRUSP8Tyr717PSKLKRSySSPDITQphosphorylation
up-regulates activity		29472535SIGNOR-279037
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
EGFRphosphorylation
up-regulates
→
USP8
PTyr810		phosphorylation
up-regulates
→		USP829472535SIGNOR-279038
EGFRphosphorylation
up-regulates
→
USP8
PTyr717		phosphorylation
up-regulates
→		USP829472535SIGNOR-279037
Regulator Mechanism/Effect Target SIGNOR-ID
EGFRphosphorylation
→
up-regulates activity 		USP8SIGNOR-279038
EGFRphosphorylation
→
up-regulates activity 		USP8SIGNOR-279037