| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCB | CASR | Thr888 | FKVAARAtLRRSNVS | phosphorylation down-regulates activity | 12356761 | SIGNOR-249176 |
| PRKCA | CASR | Thr888 | FKVAARAtLRRSNVS | phosphorylation down-regulates | 21135065 | SIGNOR-170334 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCB | phosphorylation up-regulates → | CASR PThr888 | phosphorylation down-regulates ⊣ | CASR | 12356761 | SIGNOR-249176 |
| PRKCA | phosphorylation up-regulates → | CASR PThr888 | phosphorylation down-regulates ⊣ | CASR | 21135065 | SIGNOR-170334 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCB | phosphorylation → down-regulates activity | CASR | SIGNOR-249176 |
| PRKCA | phosphorylation down-regulates | CASR | SIGNOR-170334 |
