Entity Details

Name AQP2
ID P41181
Role substrate
Enzymatic Domains
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CDK18AQP2Ser261RQSVELHsPQSLPRGphosphorylation
down-regulates quantity by destabilization		32164329SIGNOR-264562
CyclinA2/CDK18AQP2Ser261RQSVELHsPQSLPRGphosphorylation
down-regulates quantity by destabilization		32164329SIGNOR-273438
PKAAQP2Ser256REVRRRQsVELHSPQphosphorylation
up-regulates activity		12194985SIGNOR-264563
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CDK18phosphorylation
up-regulates
→
AQP2
PSer261		phosphorylation
down-regulates
⊣		AQP232164329SIGNOR-264562
CyclinA2/CDK18phosphorylation
up-regulates
→
AQP2
PSer261		phosphorylation
down-regulates
⊣		AQP232164329SIGNOR-273438
PKAphosphorylation
up-regulates
→
AQP2
PSer256		phosphorylation
up-regulates
→		AQP212194985SIGNOR-264563
Regulator Mechanism/Effect Target SIGNOR-ID
CDK18phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		AQP2SIGNOR-264562
CyclinA2/CDK18phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		AQP2SIGNOR-273438
PKAphosphorylation
→
up-regulates activity 		AQP2SIGNOR-264563