Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
AKT	PRPH	Ser59	SSSVRLGsFRSPRAG	phosphorylation up-regulates activity	17569669	SIGNOR-262627

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
AKT	phosphorylation up-regulates →	PRPH PSer59	phosphorylation up-regulates →	PRPH	17569669	SIGNOR-262627

Regulator	Mechanism/Effect	Target	SIGNOR-ID
AKT	phosphorylation → up-regulates activity	PRPH	SIGNOR-262627