| Name | HNF4A |
| ID | P41235 |
| Role | substrate |
| Enzymatic Domains |
NR LBD 147-377 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKAA2 | HNF4A | Ser313 | GKIKRLRsQVQVSLE | phosphorylation down-regulates quantity by destabilization | 12740371 | SIGNOR-250322 |
| SRC | HNF4A | Tyr288 | IDDNEYAyLKAIIFF | phosphorylation down-regulates | 22308320 | SIGNOR-195900 |
| AMPK | HNF4A | Ser303 | DPDAKGLsDPGKIKR | phosphorylation down-regulates | 12740371 | SIGNOR-216511 |
| SRC | HNF4A | Tyr23 | SAALDPAyTTLEFEN | phosphorylation down-regulates | 22308320 | SIGNOR-195883 |
| AMPK | HNF4A | Ser303 | DPDAKGLsDPGKIKR | phosphorylation down-regulates activity | 12740371 | SIGNOR-263106 |
| SRC | HNF4A | Tyr286 | LQIDDNEyAYLKAII | phosphorylation down-regulates | 22308320 | SIGNOR-195896 |
| PRKAA1 | HNF4A | Ser303 | DPDAKGLsDPGKIKR | phosphorylation down-regulates activity | 12740371 | SIGNOR-101101 |
| p38 | HNF4A | Ser167 | VLSRQITsPVSGING | phosphorylation up-regulates | 16351573 | SIGNOR-143046 |
| MAPK3 | HNF4A | – | phosphorylation down-regulates activity | 28196117 | SIGNOR-279070 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKAA2 | phosphorylation up-regulates → | HNF4A PSer313 | phosphorylation down-regulates ⊣ | HNF4A | 12740371 | SIGNOR-250322 |
| SRC | phosphorylation up-regulates → | HNF4A PTyr288 | phosphorylation down-regulates ⊣ | HNF4A | 22308320 | SIGNOR-195900 |
| AMPK | phosphorylation up-regulates → | HNF4A PSer303 | phosphorylation down-regulates ⊣ | HNF4A | 12740371 | SIGNOR-216511 |
| SRC | phosphorylation up-regulates → | HNF4A PTyr23 | phosphorylation down-regulates ⊣ | HNF4A | 22308320 | SIGNOR-195883 |
| AMPK | phosphorylation up-regulates → | HNF4A PSer303 | phosphorylation down-regulates ⊣ | HNF4A | 12740371 | SIGNOR-263106 |
| SRC | phosphorylation up-regulates → | HNF4A PTyr286 | phosphorylation down-regulates ⊣ | HNF4A | 22308320 | SIGNOR-195896 |
| PRKAA1 | phosphorylation up-regulates → | HNF4A PSer303 | phosphorylation down-regulates ⊣ | HNF4A | 12740371 | SIGNOR-101101 |
| p38 | phosphorylation up-regulates → | HNF4A PSer167 | phosphorylation up-regulates → | HNF4A | 16351573 | SIGNOR-143046 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKAA2 | phosphorylation down-regulates quantity by destabilization | HNF4A | SIGNOR-250322 |
| SRC | phosphorylation down-regulates | HNF4A | SIGNOR-195900 |
| AMPK | phosphorylation down-regulates | HNF4A | SIGNOR-216511 |
| SRC | phosphorylation down-regulates | HNF4A | SIGNOR-195883 |
| AMPK | phosphorylation → down-regulates activity | HNF4A | SIGNOR-263106 |
| SRC | phosphorylation down-regulates | HNF4A | SIGNOR-195896 |
| PRKAA1 | phosphorylation → down-regulates activity | HNF4A | SIGNOR-101101 |
| p38 | phosphorylation → up-regulates | HNF4A | SIGNOR-143046 |
| MAPK3 | phosphorylation → down-regulates activity | HNF4A | SIGNOR-279070 |