| Name | MAP3K8 |
| ID | P41279 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 138-388 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP3K8 | MAP2K2 | Ser222 | VSGQLIDsMANSFVG | phosphorylation up-regulates | 15466476 | SIGNOR-129694 |
| MAP3K8 | MAP2K2 | Ser226 | LIDSMANsFVGTRSY | phosphorylation up-regulates | 15466476 | SIGNOR-129698 |
| MAP3K8 | MAP2K4 | – | phosphorylation up-regulates | 22435554 | SIGNOR-196744 | |
| MAP3K8 | PLK1 | Thr210 | YDGERKKtLCGTPNY | phosphorylation up-regulates | 12207013 | SIGNOR-92274 |
| MAP3K8 | PLCB3 | Ser537 | PSLEPQKsLGDEGLN | phosphorylation up-regulates activity | 21868363 | SIGNOR-278519 |
| MAP3K8 | MAP2K1 | Ser218 | VSGQLIDsMANSFVG | phosphorylation up-regulates | 15466476 | SIGNOR-129690 |
| MAP3K8 | MAP2K1 | Ser222 | LIDSMANsFVGTRSY | phosphorylation up-regulates | 8131746 | SIGNOR-36449 |
| MAP3K8 | MAP2K1 | Ser244 | GTHYSVQsDIWSMGL | phosphorylation up-regulates | 8131746 | SIGNOR-36453 |
| MAP3K8 | MAP2K1 | Ser248 | SVQSDIWsMGLSLVE | phosphorylation up-regulates | 8131746 | SIGNOR-36457 |
| MAP3K8 | MAP3K14 | Thr559 | TGDYIPGtETHMAPE | phosphorylation up-regulates activity | 9742107 | SIGNOR-249387 |
| MAP3K8 | MEK1/2 | – | phosphorylation up-regulates | 15466476 | SIGNOR-244904 | |
| MAP3K8 | MEK1/2 | – | phosphorylation up-regulates | 8131746 | SIGNOR-244892 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP3K8 | phosphorylation up-regulates → | MAP2K2 PSer222 | phosphorylation up-regulates → | MAP2K2 | 15466476 | SIGNOR-129694 |
| MAP3K8 | phosphorylation up-regulates → | MAP2K2 PSer226 | phosphorylation up-regulates → | MAP2K2 | 15466476 | SIGNOR-129698 |
| MAP3K8 | phosphorylation up-regulates → | PLK1 PThr210 | phosphorylation up-regulates → | PLK1 | 12207013 | SIGNOR-92274 |
| MAP3K8 | phosphorylation up-regulates → | PLCB3 PSer537 | phosphorylation up-regulates → | PLCB3 | 21868363 | SIGNOR-278519 |
| MAP3K8 | phosphorylation up-regulates → | MAP2K1 PSer218 | phosphorylation up-regulates → | MAP2K1 | 15466476 | SIGNOR-129690 |
| MAP3K8 | phosphorylation up-regulates → | MAP2K1 PSer222 | phosphorylation up-regulates → | MAP2K1 | 8131746 | SIGNOR-36449 |
| MAP3K8 | phosphorylation up-regulates → | MAP2K1 PSer244 | phosphorylation up-regulates → | MAP2K1 | 8131746 | SIGNOR-36453 |
| MAP3K8 | phosphorylation up-regulates → | MAP2K1 PSer248 | phosphorylation up-regulates → | MAP2K1 | 8131746 | SIGNOR-36457 |
| MAP3K8 | phosphorylation up-regulates → | MAP3K14 PThr559 | phosphorylation up-regulates → | MAP3K14 | 9742107 | SIGNOR-249387 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAP3K8 | phosphorylation → up-regulates | MAP2K2 | SIGNOR-129694 |
| MAP3K8 | phosphorylation → up-regulates | MAP2K2 | SIGNOR-129698 |
| MAP3K8 | phosphorylation → up-regulates | MAP2K4 | SIGNOR-196744 |
| MAP3K8 | phosphorylation → up-regulates | PLK1 | SIGNOR-92274 |
| MAP3K8 | phosphorylation → up-regulates activity | PLCB3 | SIGNOR-278519 |
| MAP3K8 | phosphorylation → up-regulates | MAP2K1 | SIGNOR-129690 |
| MAP3K8 | phosphorylation → up-regulates | MAP2K1 | SIGNOR-36449 |
| MAP3K8 | phosphorylation → up-regulates | MAP2K1 | SIGNOR-36453 |
| MAP3K8 | phosphorylation → up-regulates | MAP2K1 | SIGNOR-36457 |
| MAP3K8 | phosphorylation → up-regulates activity | MAP3K14 | SIGNOR-249387 |
| MAP3K8 | phosphorylation → up-regulates | MEK1/2 | SIGNOR-244904 |
| MAP3K8 | phosphorylation → up-regulates | MEK1/2 | SIGNOR-244892 |