Entity Details

Name MAP3K8
ID P41279
Role substrate
Enzymatic Domains
Protein kinase 138-388
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
AKTMAP3K8Ser400
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EDQPRCQsLDSALLEphosphorylation
up-regulates activity		12138205SIGNOR-251480
AKT1MAP3K8Ser400
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EDQPRCQsLDSALLEphosphorylation
up-regulates activity		12138205SIGNOR-252571
AKT1MAP3K8Ser413LERKRLLsRKELELPphosphorylation
up-regulates activity		12138205SIGNOR-252572
AKTMAP3K8Ser413LERKRLLsRKELELPphosphorylation
up-regulates activity		12138205SIGNOR-251481
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
AKTphosphorylation
up-regulates
→
MAP3K8
PSer400		phosphorylation
up-regulates
→		MAP3K812138205SIGNOR-251480
AKT1phosphorylation
up-regulates
→
MAP3K8
PSer400		phosphorylation
up-regulates
→		MAP3K812138205SIGNOR-252571
AKT1phosphorylation
up-regulates
→
MAP3K8
PSer413		phosphorylation
up-regulates
→		MAP3K812138205SIGNOR-252572
AKTphosphorylation
up-regulates
→
MAP3K8
PSer413		phosphorylation
up-regulates
→		MAP3K812138205SIGNOR-251481
Regulator Mechanism/Effect Target SIGNOR-ID
AKTphosphorylation
→
up-regulates activity 		MAP3K8SIGNOR-251480
AKT1phosphorylation
→
up-regulates activity 		MAP3K8SIGNOR-252571
AKT1phosphorylation
→
up-regulates activity 		MAP3K8SIGNOR-252572
AKTphosphorylation
→
up-regulates activity 		MAP3K8SIGNOR-251481