| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCE | GRM5 | Ser840 | VRSAFTTsTVVRMHV | phosphorylation up-regulates activity | 15894802 | SIGNOR-249281 |
| PRKCG | GRM5 | Thr841 | RSAFTTStVVRMHVG | phosphorylation up-regulates activity | 15894802 | SIGNOR-249289 |
| PRKCD | GRM5 | Thr841 | RSAFTTStVVRMHVG | phosphorylation up-regulates activity | 15894802 | SIGNOR-249287 |
| PKC | GRM5 | – | phosphorylation up-regulates activity | 15894802 | SIGNOR-269972 | |
| PRKCB | GRM5 | Ser840 | VRSAFTTsTVVRMHV | phosphorylation up-regulates activity | 15894802 | SIGNOR-249279 |
| PRKCZ | GRM5 | Ser840 | VRSAFTTsTVVRMHV | phosphorylation up-regulates activity | 15894802 | SIGNOR-249284 |
| PRKCA | GRM5 | Thr841 | RSAFTTStVVRMHVG | phosphorylation up-regulates activity | 15894802 | SIGNOR-249285 |
| PRKCB | GRM5 | Thr841 | RSAFTTStVVRMHVG | phosphorylation up-regulates activity | 15894802 | SIGNOR-249286 |
| PRKCD | GRM5 | Ser840 | VRSAFTTsTVVRMHV | phosphorylation up-regulates activity | 15894802 | SIGNOR-249280 |
| PRKCE | GRM5 | Thr841 | RSAFTTStVVRMHVG | phosphorylation up-regulates activity | 15894802 | SIGNOR-249288 |
| PRKCZ | GRM5 | Thr841 | RSAFTTStVVRMHVG | phosphorylation up-regulates activity | 15894802 | SIGNOR-249291 |
| PRKCQ | GRM5 | Thr841 | RSAFTTStVVRMHVG | phosphorylation up-regulates activity | 15894802 | SIGNOR-249290 |
| PRKCG | GRM5 | Ser840 | VRSAFTTsTVVRMHV | phosphorylation up-regulates activity | 15894802 | SIGNOR-249282 |
| PRKCQ | GRM5 | Ser840 | VRSAFTTsTVVRMHV | phosphorylation up-regulates activity | 15894802 | SIGNOR-249283 |
| PRKCA | GRM5 | Ser840 | VRSAFTTsTVVRMHV | phosphorylation up-regulates activity | 15894802 | SIGNOR-249278 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCE | phosphorylation up-regulates → | GRM5 PSer840 | phosphorylation up-regulates → | GRM5 | 15894802 | SIGNOR-249281 |
| PRKCG | phosphorylation up-regulates → | GRM5 PThr841 | phosphorylation up-regulates → | GRM5 | 15894802 | SIGNOR-249289 |
| PRKCD | phosphorylation up-regulates → | GRM5 PThr841 | phosphorylation up-regulates → | GRM5 | 15894802 | SIGNOR-249287 |
| PRKCB | phosphorylation up-regulates → | GRM5 PSer840 | phosphorylation up-regulates → | GRM5 | 15894802 | SIGNOR-249279 |
| PRKCZ | phosphorylation up-regulates → | GRM5 PSer840 | phosphorylation up-regulates → | GRM5 | 15894802 | SIGNOR-249284 |
| PRKCA | phosphorylation up-regulates → | GRM5 PThr841 | phosphorylation up-regulates → | GRM5 | 15894802 | SIGNOR-249285 |
| PRKCB | phosphorylation up-regulates → | GRM5 PThr841 | phosphorylation up-regulates → | GRM5 | 15894802 | SIGNOR-249286 |
| PRKCD | phosphorylation up-regulates → | GRM5 PSer840 | phosphorylation up-regulates → | GRM5 | 15894802 | SIGNOR-249280 |
| PRKCE | phosphorylation up-regulates → | GRM5 PThr841 | phosphorylation up-regulates → | GRM5 | 15894802 | SIGNOR-249288 |
| PRKCZ | phosphorylation up-regulates → | GRM5 PThr841 | phosphorylation up-regulates → | GRM5 | 15894802 | SIGNOR-249291 |
| PRKCQ | phosphorylation up-regulates → | GRM5 PThr841 | phosphorylation up-regulates → | GRM5 | 15894802 | SIGNOR-249290 |
| PRKCG | phosphorylation up-regulates → | GRM5 PSer840 | phosphorylation up-regulates → | GRM5 | 15894802 | SIGNOR-249282 |
| PRKCQ | phosphorylation up-regulates → | GRM5 PSer840 | phosphorylation up-regulates → | GRM5 | 15894802 | SIGNOR-249283 |
| PRKCA | phosphorylation up-regulates → | GRM5 PSer840 | phosphorylation up-regulates → | GRM5 | 15894802 | SIGNOR-249278 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCE | phosphorylation → up-regulates activity | GRM5 | SIGNOR-249281 |
| PRKCG | phosphorylation → up-regulates activity | GRM5 | SIGNOR-249289 |
| PRKCD | phosphorylation → up-regulates activity | GRM5 | SIGNOR-249287 |
| PKC | phosphorylation → up-regulates activity | GRM5 | SIGNOR-269972 |
| PRKCB | phosphorylation → up-regulates activity | GRM5 | SIGNOR-249279 |
| PRKCZ | phosphorylation → up-regulates activity | GRM5 | SIGNOR-249284 |
| PRKCA | phosphorylation → up-regulates activity | GRM5 | SIGNOR-249285 |
| PRKCB | phosphorylation → up-regulates activity | GRM5 | SIGNOR-249286 |
| PRKCD | phosphorylation → up-regulates activity | GRM5 | SIGNOR-249280 |
| PRKCE | phosphorylation → up-regulates activity | GRM5 | SIGNOR-249288 |
| PRKCZ | phosphorylation → up-regulates activity | GRM5 | SIGNOR-249291 |
| PRKCQ | phosphorylation → up-regulates activity | GRM5 | SIGNOR-249290 |
| PRKCG | phosphorylation → up-regulates activity | GRM5 | SIGNOR-249282 |
| PRKCQ | phosphorylation → up-regulates activity | GRM5 | SIGNOR-249283 |
| PRKCA | phosphorylation → up-regulates activity | GRM5 | SIGNOR-249278 |
