Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
JAK2	STAT6	–		phosphorylation up-regulates activity	18852293	SIGNOR-249532
TBK1	STAT6	Tyr641 View in OncoXplorer	MGKDGRGyVPATIKM	phosphorylation up-regulates	22000020	SIGNOR-176775
MAPK8	STAT6	Ser707	IPPYQGLsPEESVNV	phosphorylation down-regulates	21123173	SIGNOR-170153
PTPN2	STAT6	–		dephosphorylation down-regulates activity	17210636	SIGNOR-235192
JAK2	STAT6	–		phosphorylation up-regulates activity	9852261	SIGNOR-62585
JAK1	STAT6	–		phosphorylation up-regulates activity	9852261	SIGNOR-62582
JAK1	STAT6	–		phosphorylation up-regulates activity	23124025	SIGNOR-249531
TBK1	STAT6	Ser407	PIQLQALsLPLVVIV	phosphorylation up-regulates	22000020	SIGNOR-176771
PTPN1	STAT6	–		dephosphorylation down-regulates activity	22156494	SIGNOR-277122

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
TBK1	phosphorylation up-regulates →	STAT6 PTyr641	phosphorylation up-regulates →	STAT6	22000020	SIGNOR-176775
MAPK8	phosphorylation up-regulates →	STAT6 PSer707	phosphorylation down-regulates ⊣	STAT6	21123173	SIGNOR-170153
TBK1	phosphorylation up-regulates →	STAT6 PSer407	phosphorylation up-regulates →	STAT6	22000020	SIGNOR-176771

Regulator	Mechanism/Effect	Target	SIGNOR-ID
JAK2	phosphorylation → up-regulates activity	STAT6	SIGNOR-249532
TBK1	phosphorylation → up-regulates	STAT6	SIGNOR-176775
MAPK8	phosphorylation down-regulates	STAT6	SIGNOR-170153
PTPN2	dephosphorylation → down-regulates activity	STAT6	SIGNOR-235192
JAK2	phosphorylation → up-regulates activity	STAT6	SIGNOR-62585
JAK1	phosphorylation → up-regulates activity	STAT6	SIGNOR-62582
JAK1	phosphorylation → up-regulates activity	STAT6	SIGNOR-249531
TBK1	phosphorylation → up-regulates	STAT6	SIGNOR-176771
PTPN1	dephosphorylation → down-regulates activity	STAT6	SIGNOR-277122