| Name | PIK3CB |
| ID | P42338 |
| Role | kinase |
| Enzymatic Domains |
PI3K-ABD 26-115 PROSITE-ProRule
PI3K-RBD 194-285 PROSITE-ProRule
C2 PI3K-type 327-496 PROSITE-ProRule
PIK helical 524-701 PROSITE-ProRule
PI3K/PI4K catalytic 772-1053 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PIK3CB | PIK3CB | Ser1070 | TVRKDYRs | phosphorylation down-regulates activity | 12502714 | SIGNOR-96776 |
| PIK3CB | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 23504389 | SIGNOR-279089 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PIK3CB | phosphorylation up-regulates → | PIK3CB PSer1070 | phosphorylation down-regulates ⊣ | PIK3CB | 12502714 | SIGNOR-96776 |
| PIK3CB | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 23504389 | SIGNOR-279089 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PIK3CB | phosphorylation → down-regulates activity | PIK3CB | SIGNOR-96776 |
| PIK3CB | phosphorylation → down-regulates activity | GSK3B | SIGNOR-279089 |