Entity Details

Name TEC
ID P42680
Role kinase
Enzymatic Domains
SH3 179-239
PROSITE-ProRule
SH2 247-345
PROSITE-ProRule
Protein kinase 370-623
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
TECMAFTyr21TSPLAMEyVNDFDLMphosphorylation
up-regulates activity		25993510SIGNOR-279433
TECTECTyr206RLERGQEyLILEKNDphosphorylation
up-regulates		12573241SIGNOR-98098
TECBMXTyr224DSNSKKIyGSQPNFNphosphorylation
up-regulates		12573241SIGNOR-98094
TECBMXTyr216SSTSLAQyDSNSKKIphosphorylation
up-regulates activity		12573241SIGNOR-246647
TECBTKTyr223LKKVVALyDYMPMNAphosphorylation
down-regulates activity		12573241SIGNOR-246652
TECSTAP1–phosphorylation
up-regulates activity		10518561SIGNOR-261817
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
TECphosphorylation
up-regulates
→
MAF
PTyr21		phosphorylation
up-regulates
→		MAF25993510SIGNOR-279433
TECphosphorylation
up-regulates
→
TEC
PTyr206		phosphorylation
up-regulates
→		TEC12573241SIGNOR-98098
TECphosphorylation
up-regulates
→
BMX
PTyr224		phosphorylation
up-regulates
→		BMX12573241SIGNOR-98094
TECphosphorylation
up-regulates
→
BMX
PTyr216		phosphorylation
up-regulates
→		BMX12573241SIGNOR-246647
TECphosphorylation
up-regulates
→
BTK
PTyr223		phosphorylation
down-regulates
⊣		BTK12573241SIGNOR-246652
Regulator Mechanism/Effect Target SIGNOR-ID
TECphosphorylation
→
up-regulates activity 		MAFSIGNOR-279433
TECphosphorylation
→
up-regulates 		TECSIGNOR-98098
TECphosphorylation
→
up-regulates 		BMXSIGNOR-98094
TECphosphorylation
→
up-regulates activity 		BMXSIGNOR-246647
TECphosphorylation
→
down-regulates activity 		BTKSIGNOR-246652
TECphosphorylation
→
up-regulates activity 		STAP1SIGNOR-261817