Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PTPN12	WAS	Tyr291 View in OncoXplorer	AETSKLIyDFIEDQG	dephosphorylation down-regulates activity	14707117	SIGNOR-248660
HCK	WAS	Tyr291 View in OncoXplorer	AETSKLIyDFIEDQG	phosphorylation up-regulates activity	12235133	SIGNOR-251268
FYN	WAS	Tyr291 View in OncoXplorer	AETSKLIyDFIEDQG	phosphorylation up-regulates activity	14707117	SIGNOR-273960
FYN	WAS	–		phosphorylation up-regulates activity	14707117	SIGNOR-279333
CSNK2A2	WAS	Ser483 View in OncoXplorer	KRSRAIHsSDEGEDQ	phosphorylation up-regulates activity	12769847	SIGNOR-251048
CSNK2A1	WAS	Ser483 View in OncoXplorer	KRSRAIHsSDEGEDQ	phosphorylation up-regulates	12769847	SIGNOR-101264
PTPN12	WAS	–		dephosphorylation down-regulates	11711533	SIGNOR-111688
HCK	WAS	Tyr291 View in OncoXplorer	AETSKLIyDFIEDQG	phosphorylation up-regulates activity	12235133	SIGNOR-273957
LYN	WAS	Tyr291 View in OncoXplorer	AETSKLIyDFIEDQG	phosphorylation up-regulates activity	17890224	SIGNOR-273959
PTPN12	WAS	–		dephosphorylation down-regulates	14707117	SIGNOR-121136
BTK	WAS	Tyr291 View in OncoXplorer	AETSKLIyDFIEDQG	phosphorylation unknown	10068673	SIGNOR-86004
BTK	WAS	Tyr291 View in OncoXplorer	AETSKLIyDFIEDQG	phosphorylation up-regulates activity	10068673	SIGNOR-273958
CSNK2A1	WAS	Ser484 View in OncoXplorer	RSRAIHSsDEGEDQA	phosphorylation up-regulates	12769847	SIGNOR-101268
CSNK2A2	WAS	Ser484 View in OncoXplorer	RSRAIHSsDEGEDQA	phosphorylation up-regulates activity	12769847	SIGNOR-251049

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PTPN12	dephosphorylation down-regulates ⊣	WAS PTyr291	dephosphorylation up-regulates →	WAS	14707117	SIGNOR-248660
HCK	phosphorylation up-regulates →	WAS PTyr291	phosphorylation up-regulates →	WAS	12235133	SIGNOR-251268
FYN	phosphorylation up-regulates →	WAS PTyr291	phosphorylation up-regulates →	WAS	14707117	SIGNOR-273960
CSNK2A2	phosphorylation up-regulates →	WAS PSer483	phosphorylation up-regulates →	WAS	12769847	SIGNOR-251048
CSNK2A1	phosphorylation up-regulates →	WAS PSer483	phosphorylation up-regulates →	WAS	12769847	SIGNOR-101264
HCK	phosphorylation up-regulates →	WAS PTyr291	phosphorylation up-regulates →	WAS	12235133	SIGNOR-273957
LYN	phosphorylation up-regulates →	WAS PTyr291	phosphorylation up-regulates →	WAS	17890224	SIGNOR-273959
BTK	phosphorylation up-regulates →	WAS PTyr291	phosphorylation down-regulates ⊣	WAS	10068673	SIGNOR-86004
BTK	phosphorylation up-regulates →	WAS PTyr291	phosphorylation up-regulates →	WAS	10068673	SIGNOR-273958
CSNK2A1	phosphorylation up-regulates →	WAS PSer484	phosphorylation up-regulates →	WAS	12769847	SIGNOR-101268
CSNK2A2	phosphorylation up-regulates →	WAS PSer484	phosphorylation up-regulates →	WAS	12769847	SIGNOR-251049

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PTPN12	dephosphorylation → down-regulates activity	WAS	SIGNOR-248660
HCK	phosphorylation → up-regulates activity	WAS	SIGNOR-251268
FYN	phosphorylation → up-regulates activity	WAS	SIGNOR-273960
FYN	phosphorylation → up-regulates activity	WAS	SIGNOR-279333
CSNK2A2	phosphorylation → up-regulates activity	WAS	SIGNOR-251048
CSNK2A1	phosphorylation → up-regulates	WAS	SIGNOR-101264
PTPN12	dephosphorylation down-regulates	WAS	SIGNOR-111688
HCK	phosphorylation → up-regulates activity	WAS	SIGNOR-273957
LYN	phosphorylation → up-regulates activity	WAS	SIGNOR-273959
PTPN12	dephosphorylation down-regulates	WAS	SIGNOR-121136
BTK	phosphorylation → unknown	WAS	SIGNOR-86004
BTK	phosphorylation → up-regulates activity	WAS	SIGNOR-273958
CSNK2A1	phosphorylation → up-regulates	WAS	SIGNOR-101268
CSNK2A2	phosphorylation → up-regulates activity	WAS	SIGNOR-251049