| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BTK | WAS | Tyr291 | AETSKLIyDFIEDQG | phosphorylation unknown | 10068673 | SIGNOR-86004 |
| HCK | WAS | Tyr291 | AETSKLIyDFIEDQG | phosphorylation up-regulates activity | 12235133 | SIGNOR-273957 |
| BTK | WAS | Tyr291 | AETSKLIyDFIEDQG | phosphorylation up-regulates activity | 10068673 | SIGNOR-273958 |
| FYN | WAS | Tyr291 | AETSKLIyDFIEDQG | phosphorylation up-regulates activity | 14707117 | SIGNOR-273960 |
| PTPN12 | WAS | Tyr291 | AETSKLIyDFIEDQG | dephosphorylation down-regulates activity | 14707117 | SIGNOR-248660 |
| HCK | WAS | Tyr291 | AETSKLIyDFIEDQG | phosphorylation up-regulates activity | 12235133 | SIGNOR-251268 |
| LYN | WAS | Tyr291 | AETSKLIyDFIEDQG | phosphorylation up-regulates activity | 17890224 | SIGNOR-273959 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BTK | phosphorylation up-regulates → | WAS PTyr291 | phosphorylation down-regulates ⊣ | WAS | 10068673 | SIGNOR-86004 |
| HCK | phosphorylation up-regulates → | WAS PTyr291 | phosphorylation up-regulates → | WAS | 12235133 | SIGNOR-273957 |
| BTK | phosphorylation up-regulates → | WAS PTyr291 | phosphorylation up-regulates → | WAS | 10068673 | SIGNOR-273958 |
| FYN | phosphorylation up-regulates → | WAS PTyr291 | phosphorylation up-regulates → | WAS | 14707117 | SIGNOR-273960 |
| PTPN12 | dephosphorylation down-regulates ⊣ | WAS PTyr291 | dephosphorylation up-regulates → | WAS | 14707117 | SIGNOR-248660 |
| HCK | phosphorylation up-regulates → | WAS PTyr291 | phosphorylation up-regulates → | WAS | 12235133 | SIGNOR-251268 |
| LYN | phosphorylation up-regulates → | WAS PTyr291 | phosphorylation up-regulates → | WAS | 17890224 | SIGNOR-273959 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| BTK | phosphorylation → unknown | WAS | SIGNOR-86004 |
| HCK | phosphorylation → up-regulates activity | WAS | SIGNOR-273957 |
| BTK | phosphorylation → up-regulates activity | WAS | SIGNOR-273958 |
| FYN | phosphorylation → up-regulates activity | WAS | SIGNOR-273960 |
| PTPN12 | dephosphorylation → down-regulates activity | WAS | SIGNOR-248660 |
| HCK | phosphorylation → up-regulates activity | WAS | SIGNOR-251268 |
| LYN | phosphorylation → up-regulates activity | WAS | SIGNOR-273959 |
