| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | HTT | Ser2548 | TRFGRKLsIIRGIVE | phosphorylation down-regulates quantity by destabilization | 35908190 | SIGNOR-277625 |
| AKT | HTT | Ser419 | GGRSRSGsIVELIAG | phosphorylation unknown | 12062094 | SIGNOR-89696 |
| CDK5 | HTT | Ser1199 | EQASVPLsPKKGSEA | phosphorylation up-regulates | 17611284 | SIGNOR-156840 |
| CDK5 | HTT | Ser1179 | LTNPPSLsPIRRKGK | phosphorylation up-regulates | 17611284 | SIGNOR-156836 |
| SGK1 | HTT | Ser419 | GGRSRSGsIVELIAG | phosphorylation down-regulates | 14725621 | SIGNOR-121349 |
| TBK1 | HTT | Ser13 | KLMKAFEsLKSFQQQ | phosphorylation up-regulates activity | 32757223 | SIGNOR-270350 |
| AKT1 | HTT | Ser419 | GGRSRSGsIVELIAG | phosphorylation unknown | 12062094 | SIGNOR-252590 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | phosphorylation up-regulates → | HTT PSer2548 | phosphorylation down-regulates ⊣ | HTT | 35908190 | SIGNOR-277625 |
| AKT | phosphorylation up-regulates → | HTT PSer419 | phosphorylation down-regulates ⊣ | HTT | 12062094 | SIGNOR-89696 |
| CDK5 | phosphorylation up-regulates → | HTT PSer1199 | phosphorylation up-regulates → | HTT | 17611284 | SIGNOR-156840 |
| CDK5 | phosphorylation up-regulates → | HTT PSer1179 | phosphorylation up-regulates → | HTT | 17611284 | SIGNOR-156836 |
| SGK1 | phosphorylation up-regulates → | HTT PSer419 | phosphorylation down-regulates ⊣ | HTT | 14725621 | SIGNOR-121349 |
| TBK1 | phosphorylation up-regulates → | HTT PSer13 | phosphorylation up-regulates → | HTT | 32757223 | SIGNOR-270350 |
| AKT1 | phosphorylation up-regulates → | HTT PSer419 | phosphorylation down-regulates ⊣ | HTT | 12062094 | SIGNOR-252590 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKACA | phosphorylation down-regulates quantity by destabilization | HTT | SIGNOR-277625 |
| AKT | phosphorylation → unknown | HTT | SIGNOR-89696 |
| CDK5 | phosphorylation → up-regulates | HTT | SIGNOR-156840 |
| CDK5 | phosphorylation → up-regulates | HTT | SIGNOR-156836 |
| SGK1 | phosphorylation down-regulates | HTT | SIGNOR-121349 |
| TBK1 | phosphorylation → up-regulates activity | HTT | SIGNOR-270350 |
| AKT1 | phosphorylation → unknown | HTT | SIGNOR-252590 |
