| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SGK1 | HTT | Ser419 | GGRSRSGsIVELIAG | phosphorylation down-regulates | 14725621 | SIGNOR-121349 |
| AKT1 | HTT | Ser419 | GGRSRSGsIVELIAG | phosphorylation unknown | 12062094 | SIGNOR-252590 |
| AKT | HTT | Ser419 | GGRSRSGsIVELIAG | phosphorylation unknown | 12062094 | SIGNOR-89696 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SGK1 | phosphorylation up-regulates → | HTT PSer419 | phosphorylation down-regulates ⊣ | HTT | 14725621 | SIGNOR-121349 |
| AKT1 | phosphorylation up-regulates → | HTT PSer419 | phosphorylation down-regulates ⊣ | HTT | 12062094 | SIGNOR-252590 |
| AKT | phosphorylation up-regulates → | HTT PSer419 | phosphorylation down-regulates ⊣ | HTT | 12062094 | SIGNOR-89696 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SGK1 | phosphorylation down-regulates | HTT | SIGNOR-121349 |
| AKT1 | phosphorylation → unknown | HTT | SIGNOR-252590 |
| AKT | phosphorylation → unknown | HTT | SIGNOR-89696 |
