| Name | GRK6 |
| ID | P43250 |
| Role | kinase |
| Enzymatic Domains |
RGS 53-171 PROSITE-ProRule
Protein kinase 186-448 PROSITE-ProRule
AGC-kinase C-terminal 449-514 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GRK6 | SLC9A3R1 | Ser290 | PALVRSAsSDTSEEL | phosphorylation down-regulates activity | 10446210 | SIGNOR-251214 |
| GRK6 | LRP6 | – | phosphorylation up-regulates activity | 19801552 | SIGNOR-279412 | |
| GRK6 | IGF1R | Ser1321 | LPLPDRHsGHKAENG | phosphorylation down-regulates quantity by destabilization | 22509025 | SIGNOR-276412 |
| GRK6 | DRD2 | – | phosphorylation down-regulates activity | 26694375 | SIGNOR-279046 | |
| GRK6 | CXCR2 | – | phosphorylation down-regulates quantity | 28529637 | SIGNOR-279782 | |
| GRK6 | BDKRB2 | Ser366 | EPIQMENsMGTLRTS | phosphorylation down-regulates activity | 11517230 | SIGNOR-251207 |
| GRK6 | BDKRB2 | Ser373 | SMGTLRTsISVERQI | phosphorylation down-regulates activity | 11517230 | SIGNOR-251205 |
| GRK6 | BDKRB2 | Ser375 | GTLRTSIsVERQIHK | phosphorylation down-regulates activity | 11517230 | SIGNOR-251206 |
| GRK6 | GRK6 | Ser484 | VLDIEQFsTVKGVEL | phosphorylation unknown | 10334944 | SIGNOR-251211 |
| GRK6 | GRK6 | Thr485 | LDIEQFStVKGVELE | phosphorylation unknown | 10334944 | SIGNOR-251212 |
| GRK6 | MC1R | – | phosphorylation down-regulates activity | 15650023 | SIGNOR-252389 | |
| GRK6 | LTB4R | Thr308 | VAKLLEGtGSEASST | phosphorylation down-regulates activity | 12077128 | SIGNOR-251213 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GRK6 | phosphorylation up-regulates → | SLC9A3R1 PSer290 | phosphorylation down-regulates ⊣ | SLC9A3R1 | 10446210 | SIGNOR-251214 |
| GRK6 | phosphorylation up-regulates → | IGF1R PSer1321 | phosphorylation down-regulates ⊣ | IGF1R | 22509025 | SIGNOR-276412 |
| GRK6 | phosphorylation up-regulates → | BDKRB2 PSer366 | phosphorylation down-regulates ⊣ | BDKRB2 | 11517230 | SIGNOR-251207 |
| GRK6 | phosphorylation up-regulates → | BDKRB2 PSer373 | phosphorylation down-regulates ⊣ | BDKRB2 | 11517230 | SIGNOR-251205 |
| GRK6 | phosphorylation up-regulates → | BDKRB2 PSer375 | phosphorylation down-regulates ⊣ | BDKRB2 | 11517230 | SIGNOR-251206 |
| GRK6 | phosphorylation up-regulates → | GRK6 PSer484 | phosphorylation down-regulates ⊣ | GRK6 | 10334944 | SIGNOR-251211 |
| GRK6 | phosphorylation up-regulates → | GRK6 PThr485 | phosphorylation down-regulates ⊣ | GRK6 | 10334944 | SIGNOR-251212 |
| GRK6 | phosphorylation up-regulates → | LTB4R PThr308 | phosphorylation down-regulates ⊣ | LTB4R | 12077128 | SIGNOR-251213 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GRK6 | phosphorylation → down-regulates activity | SLC9A3R1 | SIGNOR-251214 |
| GRK6 | phosphorylation → up-regulates activity | LRP6 | SIGNOR-279412 |
| GRK6 | phosphorylation down-regulates quantity by destabilization | IGF1R | SIGNOR-276412 |
| GRK6 | phosphorylation → down-regulates activity | DRD2 | SIGNOR-279046 |
| GRK6 | phosphorylation → down-regulates quantity | CXCR2 | SIGNOR-279782 |
| GRK6 | phosphorylation → down-regulates activity | BDKRB2 | SIGNOR-251207 |
| GRK6 | phosphorylation → down-regulates activity | BDKRB2 | SIGNOR-251205 |
| GRK6 | phosphorylation → down-regulates activity | BDKRB2 | SIGNOR-251206 |
| GRK6 | phosphorylation → unknown | GRK6 | SIGNOR-251211 |
| GRK6 | phosphorylation → unknown | GRK6 | SIGNOR-251212 |
| GRK6 | phosphorylation → down-regulates activity | MC1R | SIGNOR-252389 |
| GRK6 | phosphorylation → down-regulates activity | LTB4R | SIGNOR-251213 |