| Name | PTPN9 |
| ID | P43378 |
| Role | phosphatase |
| Enzymatic Domains |
CRAL-TRIO 84-243 PROSITE-ProRule
Tyrosine-protein phosphatase 303-574 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN9 | EGFR | – | dephosphorylation down-regulates activity | 20335174 | SIGNOR-277130 | |
| PTPN9 | ERBB2 | – | dephosphorylation down-regulates activity | 20335174 | SIGNOR-277170 | |
| PTPN9 | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 16679294 | SIGNOR-146668 |
| PTPN9 | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 16679294 | SIGNOR-146672 |
| PTPN9 | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates | 16679294 | SIGNOR-146676 |
| PTPN9 | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 16679294 | SIGNOR-146680 |
| PTPN9 | GHR | – | dephosphorylation down-regulates | 12907755 | SIGNOR-104577 | |
| PTPN9 | GHR | – | dephosphorylation down-regulates activity | 12907755 | SIGNOR-248505 | |
| PTPN9 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates activity | 22394684 | SIGNOR-276976 |
| PTPN9 | NSF | Tyr83 | QEIEVSLyTFDKAKQ | dephosphorylation down-regulates | 15322554 | SIGNOR-128348 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN9 | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 16679294 | SIGNOR-146668 |
| PTPN9 | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 16679294 | SIGNOR-146672 |
| PTPN9 | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 16679294 | SIGNOR-146676 |
| PTPN9 | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 16679294 | SIGNOR-146680 |
| PTPN9 | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 22394684 | SIGNOR-276976 |
| PTPN9 | dephosphorylation down-regulates ⊣ | NSF PTyr83 | dephosphorylation up-regulates → | NSF | 15322554 | SIGNOR-128348 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN9 | dephosphorylation → down-regulates activity | EGFR | SIGNOR-277130 |
| PTPN9 | dephosphorylation → down-regulates activity | ERBB2 | SIGNOR-277170 |
| PTPN9 | dephosphorylation down-regulates | INSR | SIGNOR-146668 |
| PTPN9 | dephosphorylation down-regulates | INSR | SIGNOR-146672 |
| PTPN9 | dephosphorylation down-regulates | INSR | SIGNOR-146676 |
| PTPN9 | dephosphorylation down-regulates | INSR | SIGNOR-146680 |
| PTPN9 | dephosphorylation down-regulates | GHR | SIGNOR-104577 |
| PTPN9 | dephosphorylation → down-regulates activity | GHR | SIGNOR-248505 |
| PTPN9 | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-276976 |
| PTPN9 | dephosphorylation down-regulates | NSF | SIGNOR-128348 |