| Name | SYK |
| ID | P43405 |
| Role | substrate |
| Enzymatic Domains |
SH2 1 15-107 PROSITE-ProRule
SH2 2 168-259 PROSITE-ProRule
Protein kinase 371-631 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| INPP5D | SYK | – | dephosphorylation down-regulates activity | 32323266 | SIGNOR-268456 | |
| SYK | SYK | Tyr323 | STVSFNPyEPELAPW | phosphorylation up-regulates activity | 9820500 | SIGNOR-246605 |
| ABL1 | SYK | Tyr352 | TEVYESPyADPEEIR | phosphorylation up-regulates activity | 23100514 | SIGNOR-279665 |
| FGR | SYK | – | phosphorylation up-regulates activity | 21746961 | SIGNOR-279332 | |
| SH2B1 | SYK | – | dephosphorylation down-regulates activity | 32323266 | SIGNOR-268445 | |
| PTPN11 | SYK | – | dephosphorylation down-regulates activity | 23182168 | SIGNOR-277085 | |
| PAK2 | SYK | – | phosphorylation up-regulates activity | 14673144 | SIGNOR-279083 | |
| LYN | SYK | – | phosphorylation up-regulates activity | 30104977 | SIGNOR-279415 | |
| SYK | SYK | Tyr131 | KENLIREyVKQTWNL | phosphorylation up-regulates activity | 9820500 | SIGNOR-246601 |
| SYK | SYK | Tyr348 | LPMDTEVyESPYADP | phosphorylation up-regulates activity | 9820500 | SIGNOR-246609 |
| PTPN6 | SYK | – | dephosphorylation down-regulates | 10458769 | SIGNOR-70234 | |
| SYK | SYK | Tyr526 | LRADENYyKAQTHGK | phosphorylation up-regulates activity | 9820500 | SIGNOR-246621 |
| SYK | SYK | Tyr352 | TEVYESPyADPEEIR | phosphorylation up-regulates activity | 9820500 | SIGNOR-246613 |
| SYK | SYK | Tyr525 | ALRADENyYKAQTHG | phosphorylation up-regulates activity | 9820500 | SIGNOR-246617 |
| CHEK1 | SYK | Ser295 | GIISRIKsYSFPKPG | phosphorylation down-regulates | 22585575 | SIGNOR-197528 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SYK | phosphorylation up-regulates → | SYK PTyr323 | phosphorylation up-regulates → | SYK | 9820500 | SIGNOR-246605 |
| ABL1 | phosphorylation up-regulates → | SYK PTyr352 | phosphorylation up-regulates → | SYK | 23100514 | SIGNOR-279665 |
| SYK | phosphorylation up-regulates → | SYK PTyr131 | phosphorylation up-regulates → | SYK | 9820500 | SIGNOR-246601 |
| SYK | phosphorylation up-regulates → | SYK PTyr348 | phosphorylation up-regulates → | SYK | 9820500 | SIGNOR-246609 |
| SYK | phosphorylation up-regulates → | SYK PTyr526 | phosphorylation up-regulates → | SYK | 9820500 | SIGNOR-246621 |
| SYK | phosphorylation up-regulates → | SYK PTyr352 | phosphorylation up-regulates → | SYK | 9820500 | SIGNOR-246613 |
| SYK | phosphorylation up-regulates → | SYK PTyr525 | phosphorylation up-regulates → | SYK | 9820500 | SIGNOR-246617 |
| CHEK1 | phosphorylation up-regulates → | SYK PSer295 | phosphorylation down-regulates ⊣ | SYK | 22585575 | SIGNOR-197528 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| INPP5D | dephosphorylation → down-regulates activity | SYK | SIGNOR-268456 |
| SYK | phosphorylation → up-regulates activity | SYK | SIGNOR-246605 |
| ABL1 | phosphorylation → up-regulates activity | SYK | SIGNOR-279665 |
| FGR | phosphorylation → up-regulates activity | SYK | SIGNOR-279332 |
| SH2B1 | dephosphorylation → down-regulates activity | SYK | SIGNOR-268445 |
| PTPN11 | dephosphorylation → down-regulates activity | SYK | SIGNOR-277085 |
| PAK2 | phosphorylation → up-regulates activity | SYK | SIGNOR-279083 |
| LYN | phosphorylation → up-regulates activity | SYK | SIGNOR-279415 |
| SYK | phosphorylation → up-regulates activity | SYK | SIGNOR-246601 |
| SYK | phosphorylation → up-regulates activity | SYK | SIGNOR-246609 |
| PTPN6 | dephosphorylation down-regulates | SYK | SIGNOR-70234 |
| SYK | phosphorylation → up-regulates activity | SYK | SIGNOR-246621 |
| SYK | phosphorylation → up-regulates activity | SYK | SIGNOR-246613 |
| SYK | phosphorylation → up-regulates activity | SYK | SIGNOR-246617 |
| CHEK1 | phosphorylation down-regulates | SYK | SIGNOR-197528 |