Entity Details

Name GATA4
ID P43694
Role substrate
Enzymatic Domains
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CDK4GATA4Ser105AYTPPPVsPRFSFPGphosphorylation
down-regulates quantity by destabilization		21447557SIGNOR-276317
PKAGATA4Ser262IKPQRRLsASRRVGLphosphorylation
up-regulates activity		16109788SIGNOR-276043
CDK4GATA4Ser160GFAGSYSsPYPAYMAphosphorylation
up-regulates activity		25241353SIGNOR-279148
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CDK4phosphorylation
up-regulates
→
GATA4
PSer105		phosphorylation
down-regulates
⊣		GATA421447557SIGNOR-276317
PKAphosphorylation
up-regulates
→
GATA4
PSer262		phosphorylation
up-regulates
→		GATA416109788SIGNOR-276043
CDK4phosphorylation
up-regulates
→
GATA4
PSer160		phosphorylation
up-regulates
→		GATA425241353SIGNOR-279148
Regulator Mechanism/Effect Target SIGNOR-ID
CDK4phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		GATA4SIGNOR-276317
PKAphosphorylation
→
up-regulates activity 		GATA4SIGNOR-276043
CDK4phosphorylation
→
up-regulates activity 		GATA4SIGNOR-279148