| Name | MAPK8 |
| ID | P45983 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 26-321 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | AIMP1 | Ser140 | KKEKKQQsIAGSADS | phosphorylation down-regulates | 20510162 | SIGNOR-165763 |
| MAPK8 | MAPK8IP3 | Thr265 | GQSSAAAtPSTTGTK | phosphorylation up-regulates | 15767678 | SIGNOR-134541 |
| MAPK8 | JUNB | Thr102 | SNGVITTtPTPPGQY | phosphorylation up-regulates activity | 9889198 | SIGNOR-250120 |
| MAPK8 | FOXO3 | Ser574 | SAKHQQQsPVSQSMQ | phosphorylation up-regulates activity | 27669435 | SIGNOR-280030 |
| MAPK8 | NFATC1 | – | phosphorylation down-regulates activity | 11406366 | SIGNOR-280031 | |
| MAPK8 | NFATC4 | Ser213 | ASRFGLGsPLPSPRA | phosphorylation up-regulates activity | 17875713 | SIGNOR-280032 |
| MAPK8 | NFATC4 | Ser217 | GLGSPLPsPRASPRP | phosphorylation up-regulates activity | 17875713 | SIGNOR-280033 |
| MAPK8 | NLRP3 | – | phosphorylation up-regulates activity | 32787872 | SIGNOR-280034 | |
| MAPK8 | SP1 | Thr278 | SVSAATLtPSSQAVT | phosphorylation up-regulates | 19245816 | SIGNOR-184190 |
| MAPK8 | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates activity | 11896587 | SIGNOR-106538 |
| MAPK8 | NEIL1 | Ser61 | KELRLILsPLPGAQP | phosphorylation up-regulates activity | 27518429 | SIGNOR-278317 |
| MAPK8 | EIF4ENIF1 | Ser693 | ASITSMLsPSFTPTS | phosphorylation up-regulates | 22966201 | SIGNOR-199000 |
| MAPK8 | HSF1 | Ser363 | DTEGRPPsPPPTSTP | phosphorylation down-regulates activity | 10747973 | SIGNOR-250119 |
| MAPK8 | AP1 | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates activity | 8137421 | SIGNOR-252355 |
| MAPK8 | STK4 | Ser82 | SIMQQCDsPHVVKYY | phosphorylation up-regulates | 20028971 | SIGNOR-162327 |
| MAPK8 | MYC | Ser71 | SRRSGLCsPSYVAVT | phosphorylation up-regulates activity | 10551811 | SIGNOR-236384 |
| MAPK8 | BCL2L11 | Ser69 | GPLAPPAsPGPFATR | phosphorylation down-regulates quantity by destabilization | 18174237 | SIGNOR-160323 |
| MAPK8 | CDKN1A | Thr57 | NFDFVTEtPLEGDFA | phosphorylation up-regulates quantity by stabilization | 12058028 | SIGNOR-250118 |
| MAPK8 | BCL2 | Thr69 | SRDPVARtSPLQTPA | phosphorylation down-regulates | 18570871 | SIGNOR-179096 |
| MAPK8 | NEIL1 | Ser207 | ALQQHRPsPELTLSQ | phosphorylation up-regulates activity | 27518429 | SIGNOR-278316 |
| MAPK8 | EIF4ENIF1 | Ser513 | NLESHLMsPAEIPGQ | phosphorylation up-regulates | 22966201 | SIGNOR-198992 |
| MAPK8 | BCL2L11 | – | phosphorylation down-regulates | 18174237 | SIGNOR-160326 | |
| MAPK8 | JUNB | Thr104 | GVITTTPtPPGQYFY | phosphorylation up-regulates activity | 9889198 | SIGNOR-250121 |
| MAPK8 | TP73 | – | phosphorylation up-regulates activity | 23516355 | SIGNOR-279219 | |
| MAPK8 | RCSD1 | Ser216 | SKSKAPGsPLSSEGA | phosphorylation down-regulates activity | 15850461 | SIGNOR-263087 |
| MAPK8 | APP | Thr743 | VEVDAAVtPEERHLS | phosphorylation up-regulates | 24610780 | SIGNOR-204679 |
| MAPK8 | CTBP1 | Ser422 | AHPPHAPsPGQTVKP | phosphorylation down-regulates | 16984892 | SIGNOR-149721 |
| MAPK8 | AP1 | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates activity | 8137421 | SIGNOR-252354 |
| MAPK8 | IRS1 | Ser616 | DDGYMPMsPGVAPVP | phosphorylation down-regulates activity | 12510059 | SIGNOR-96944 |
| MAPK8 | BID | Thr59 | EGYDELQtDGNRSSH | phosphorylation up-regulates activity | 25077544 | SIGNOR-279076 |
| MAPK8 | MAPK8IP1 | Ser421 | DNCASVSsPYESAIG | phosphorylation unknown | 12756254 | SIGNOR-250126 |
| MAPK8 | KRT8 | Ser74 | TVNQSLLsPLVLEVD | phosphorylation up-regulates | 11781324 | SIGNOR-113645 |
| MAPK8 | ELK1 | Ser389 | LSPIAPRsPAKLSFQ | phosphorylation up-regulates activity | 7651411 | SIGNOR-236432 |
| MAPK8 | DIABLO | Ser6 | sWLSRSVT | phosphorylation up-regulates activity | 25310587 | SIGNOR-280029 |
| MAPK8 | NEIL1 | Ser306 | KSKATQLsPEDRVED | phosphorylation up-regulates activity | 27518429 | SIGNOR-278315 |
| MAPK8 | SP1 | Thr739 | SEGSGTAtPSALITT | phosphorylation up-regulates | 19245816 | SIGNOR-184194 |
| MAPK8 | STMN1 | Ser38 | SVPEFPLsPPKKKDL | phosphorylation down-regulates | 20630875 | SIGNOR-166694 |
| MAPK8 | KRT8 | Ser74 | TVNQSLLsPLVLEVD | phosphorylation up-regulates | 11788583 | SIGNOR-114083 |
| MAPK8 | LRP6 | – | phosphorylation up-regulates | 20974802 | SIGNOR-169007 | |
| MAPK8 | PXN | Ser178 | PPLPGALsPLYGVPE | phosphorylation up-regulates activity | 12853963 | SIGNOR-250129 |
| MAPK8 | IRS1 | Ser315 | ITATSPAsMVGGKPG | phosphorylation down-regulates | 12510059 | SIGNOR-96940 |
| MAPK8 | FOXO | Thr451 | PIPKALGtPVLTPPT | phosphorylation up-regulates | 15538382 | SIGNOR-252964 |
| MAPK8 | RCSD1 | Ser68 | GQNGEEKsPPNASHP | phosphorylation down-regulates activity | 15850461 | SIGNOR-263085 |
| MAPK8 | OSBP2 | – | phosphorylation up-regulates activity | 30925160 | SIGNOR-264876 | |
| MAPK8 | ITCH | – | phosphorylation up-regulates activity | 15358865 | SIGNOR-245315 | |
| MAPK8 | MAPK8IP1 | Ser197 | DRVSRSSsPLKTGEQ | phosphorylation unknown | 12756254 | SIGNOR-250124 |
| MAPK8 | IRS1 | Ser636 | SGDYMPMsPKSVSAP | phosphorylation down-regulates activity | 12510059 | SIGNOR-96948 |
| MAPK8 | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates | 11896587 | SIGNOR-115831 |
| MAPK8 | ATF2 | Thr71 | IVADQTPtPTRFLKN | phosphorylation up-regulates | 7737130 | SIGNOR-32425 |
| MAPK8 | ELK1 | Ser383 | IHFWSTLsPIAPRSP | phosphorylation up-regulates | 8846788 | SIGNOR-44356 |
| MAPK8 | SIRT1 | Ser47 | DGPGLERsPGEPGGA | phosphorylation up-regulates | 20027304 | SIGNOR-162318 |
| MAPK8 | EIF4ENIF1 | Ser752 | PSADRDSsPTTNSKL | phosphorylation up-regulates | 22966201 | SIGNOR-199004 |
| MAPK8 | HNRNPK | Ser353 | DSAIDTWsPSEWQMA | phosphorylation up-regulates activity | 11259409 | SIGNOR-105251 |
| MAPK8 | IRF3 | Ser173 | PCPQPLRsPSLDNPT | phosphorylation up-regulates | 19153595 | SIGNOR-183489 |
| MAPK8 | MAPK8IP1 | Thr205 | PLKTGEQtPPHEHIC | phosphorylation unknown | 12756254 | SIGNOR-250127 |
| MAPK8 | PIN1 | Ser115 | SQFSDCSsAKARGDL | phosphorylation up-regulates quantity by stabilization | 34048060 | SIGNOR-277562 |
| MAPK8 | EIF4ENIF1 | Ser301 | DAVLPEQsPGDFDFN | phosphorylation up-regulates | 22966201 | SIGNOR-198984 |
| MAPK8 | CDC25B | Ser103 | ESSLSSEsSESSDAG | phosphorylation down-regulates quantity by destabilization | 21807946 | SIGNOR-276351 |
| MAPK8 | BCL2 | Ser87 | AAAGPALsPVPPVVH | phosphorylation down-regulates activity | 10567572 | SIGNOR-48038 |
| MAPK8 | IRS1 | Ser312 | TESITATsPASMVGG | phosphorylation down-regulates quantity by destabilization | 12510059 | SIGNOR-236591 |
| MAPK8 | CDT1 | Thr29 | PPKLACRtPSPARPA | phosphorylation down-regulates activity | 21856198 | SIGNOR-278445 |
| MAPK8 | PKM | Thr365 | CIMLSGEtAKGDYPL | phosphorylation up-regulates activity | 26258887 | SIGNOR-276933 |
| MAPK8 | MAPK8IP1 | Ser15 | GLGGGAAsPPAASPF | phosphorylation unknown | 12756254 | SIGNOR-250123 |
| MAPK8 | ARHGAP8 | Ser455 | TKPTLPPsPLMAARR | phosphorylation up-regulates activity | 28092672 | SIGNOR-275550 |
| MAPK8 | IRS1 | Ser312 | TESITATsPASMVGG | phosphorylation down-regulates | 18728222 | SIGNOR-180532 |
| MAPK8 | CDC25C | Ser168 | SEMKYLGsPITTVPK | phosphorylation down-regulates | 20220133 | SIGNOR-164089 |
| MAPK8 | NFATC2 | – | phosphorylation down-regulates | 14517246 | SIGNOR-118217 | |
| MAPK8 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates activity | 23255093 | SIGNOR-235704 |
| MAPK8 | MAPK8IP3 | Thr275 | TTGTKSNtPTSSVPS | phosphorylation up-regulates | 15767678 | SIGNOR-134545 |
| MAPK8 | CDT1 | Ser491 | GSCCTIMsPGEMEKH | phosphorylation up-regulates quantity by stabilization | 21930785 | SIGNOR-276360 |
| MAPK8 | DCX | – | phosphorylation up-regulates activity | 28701917 | SIGNOR-279228 | |
| MAPK8 | CDT1 | Ser391 | LRSAAPSsPGSPRPA | phosphorylation up-regulates quantity by stabilization | 21930785 | SIGNOR-276361 |
| MAPK8 | RCSD1 | Ser83 | PKFKVKSsPLIEKLQ | phosphorylation down-regulates activity | 15850461 | SIGNOR-263086 |
| MAPK8 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates activity | 24913968 | SIGNOR-251101 |
| MAPK8 | NR4A1 | Ser95 | TSSSSATsPASASFK | phosphorylation down-regulates | 17023523 | SIGNOR-149998 |
| MAPK8 | TP53 | Thr81 | APAPAAPtPAAPAPA | phosphorylation up-regulates | 12531896 | SIGNOR-97405 |
| MAPK8 | SARM1 | Ser548 | AAREMLHsPLPCTGG | phosphorylation down-regulates activity | 30333228 | SIGNOR-275554 |
| MAPK8 | SIRT1 | Ser27 | ADREAASsPAGEPLR | phosphorylation up-regulates | 20027304 | SIGNOR-162314 |
| MAPK8 | MAPK8IP1 | Ser29 | FLGLHIAsPPNFRLT | phosphorylation unknown | 12756254 | SIGNOR-250125 |
| MAPK8 | ITCH | – | phosphorylation up-regulates activity | 16469705 | SIGNOR-245310 | |
| MAPK8 | ELK3 | – | phosphorylation down-regulates activity | 11042694 | SIGNOR-250139 | |
| MAPK8 | CDC25B | Ser101 | ASESSLSsESSESSD | phosphorylation down-regulates quantity by destabilization | 21807946 | SIGNOR-276352 |
| MAPK8 | ITCH | Ser273 | RPASVNGsPSATSES | phosphorylation up-regulates activity | 16446428 | SIGNOR-249580 |
| MAPK8 | EEF1A2 | Ser205 | GDNMLEPsPNMPWFK | phosphorylation down-regulates quantity by destabilization | 23608534 | SIGNOR-276491 |
| MAPK8 | TP53 | – | phosphorylation up-regulates | 9724739 | SIGNOR-59812 | |
| MAPK8 | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates activity | 8137421 | SIGNOR-250122 |
| MAPK8 | ATF2 | Thr69 | SVIVADQtPTPTRFL | phosphorylation up-regulates | 7824938 | SIGNOR-33914 |
| MAPK8 | BCL2L1 | Ser62 | PSWHLADsPAVNGAT | phosphorylation down-regulates | 12633850 | SIGNOR-99219 |
| MAPK8 | MCL1 | Thr163 | TDGSLPStPPPAEEE | phosphorylation up-regulates | 12223490 | SIGNOR-92597 |
| MAPK8 | WDR62 | Thr1053 | PSSSLPQtPEQEKFL | phosphorylation down-regulates quantity by destabilization | 30566428 | SIGNOR-271710 |
| MAPK8 | E2F1 | – | phosphorylation down-regulates activity | 10075927 | SIGNOR-279218 | |
| MAPK8 | JUND | Ser100 | LGLLKLAsPELERLI | phosphorylation up-regulates | 22327296 | SIGNOR-196038 |
| MAPK8 | ATN1 | Ser739 | EEYETPEsPVPPARS | phosphorylation down-regulates activity | 12812981 | SIGNOR-102398 |
| MAPK8 | BCL2 | Ser70 | RDPVARTsPLQTPAA | phosphorylation up-regulates | 18570871 | SIGNOR-179088 |
| MAPK8 | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates activity | 8137421 | SIGNOR-235766 |
| MAPK8 | SIRT1 | Thr530 | YLSELPPtPLHVSED | phosphorylation up-regulates | 20027304 | SIGNOR-162322 |
| MAPK8 | YWHAZ | Ser184 | FYYEILNsPEKACSL | phosphorylation down-regulates | 15071501 | SIGNOR-124020 |
| MAPK8 | PPM1J | Ser93 | HAGRAVQsPPDTGRR | phosphorylation down-regulates | 18553930 | SIGNOR-178930 |
| MAPK8 | EIF4ENIF1 | Ser587 | YLRPRIPsPIGFTPG | phosphorylation up-regulates | 22966201 | SIGNOR-198996 |
| MAPK8 | IRS1 | Ser307 | TRRSRTEsITATSPA | phosphorylation down-regulates | 14579029 | SIGNOR-118857 |
| MAPK8 | HNRNPK | Ser353 | DSAIDTWsPSEWQMA | phosphorylation up-regulates | 11259409 | SIGNOR-105770 |
| MAPK8 | SYT4 | Ser135 | EGEKESVsPESLKSS | phosphorylation up-regulates activity | 18046461 | SIGNOR-273673 |
| MAPK8 | MAPK8IP1 | Thr103 | LIDATGDtPGAEDDE | phosphorylation up-regulates activity | 12756254 | SIGNOR-250128 |
| MAPK8 | ELK1 | Ser389 | LSPIAPRsPAKLSFQ | phosphorylation up-regulates activity | 8846788 | SIGNOR-236455 |
| MAPK8 | IRS1 | Ser307 | TRRSRTEsITATSPA | phosphorylation down-regulates | 12510059 | SIGNOR-96936 |
| MAPK8 | BCL2 | Ser70 | RDPVARTsPLQTPAA | phosphorylation up-regulates | 10567572 | SIGNOR-72125 |
| MAPK8 | BCL2L11 | Ser77 | PGPFATRsPLFIFMR | phosphorylation up-regulates activity | 12818176 | SIGNOR-250133 |
| MAPK8 | IRS1 | Ser315 | ITATSPAsMVGGKPG | phosphorylation down-regulates | 14579029 | SIGNOR-118861 |
| MAPK8 | FOXO4 | Thr455 | ALGTPVLtPPTEAAS | phosphorylation up-regulates | 15538382 | SIGNOR-130385 |
| MAPK8 | ITCH | Ser240 | RRVSGNNsPSLSNGG | phosphorylation up-regulates activity | 16446428 | SIGNOR-245323 |
| MAPK8 | PKMYT1 | – | phosphorylation up-regulates | 19204086 | SIGNOR-183899 | |
| MAPK8 | MAPK9 | – | phosphorylation up-regulates | 17525747 | SIGNOR-155205 | |
| MAPK8 | TP53 | Thr81 | APAPAAPtPAAPAPA | phosphorylation up-regulates quantity by stabilization | 11283254 | SIGNOR-106542 |
| MAPK8 | MFN2 | Ser27 | HMAEVNASPLKHFVT | phosphorylation down-regulates quantity | 22748923 | SIGNOR-274138 |
| MAPK8 | LAT | Thr184 | PSAPALStPGIRDSA | phosphorylation down-regulates | 15192708 | SIGNOR-125774 |
| MAPK8 | BMF | – | phosphorylation up-regulates activity | 12591950 | SIGNOR-250116 | |
| MAPK8 | BCL2L11 | Ser69 | GPLAPPAsPGPFATR | phosphorylation down-regulates quantity by destabilization | 15486195 | SIGNOR-250132 |
| MAPK8 | YWHAB | Ser186 | FYYEILNsPEKACSL | phosphorylation down-regulates | 15696159 | SIGNOR-133875 |
| MAPK8 | AKT1 | Thr450 | TAQMITItPPDQDDS | phosphorylation up-regulates activity | 16306447 | SIGNOR-252426 |
| MAPK8 | HNRNPK | Ser216 | ILDLISEsPIKGRAQ | phosphorylation up-regulates activity | 11259409 | SIGNOR-105247 |
| MAPK8 | NLRP3 | Ser198 | GKTKTCEsPVSPIKM | phosphorylation up-regulates activity | 28943315 | SIGNOR-277324 |
| MAPK8 | ITCH | – | phosphorylation up-regulates | 16469705 | SIGNOR-144456 | |
| MAPK8 | MCL1 | Thr163 | TDGSLPStPPPAEEE | phosphorylation up-regulates | 18676833 | SIGNOR-179816 |
| MAPK8 | SFN | Ser186 | FHYEIANsPEEAISL | phosphorylation down-regulates | 15071501 | SIGNOR-124016 |
| MAPK8 | EIF4ENIF1 | Ser374 | GLEQAILsPGQNSGN | phosphorylation up-regulates | 22966201 | SIGNOR-198988 |
| MAPK8 | NFE2 | Ser157 | LNYSDAEsLELEGTE | phosphorylation down-regulates quantity by destabilization | 19966288 | SIGNOR-275552 |
| MAPK8 | ITCH | Thr263 | PSRPPPPtPRRPASV | phosphorylation up-regulates activity | 16446428 | SIGNOR-249579 |
| MAPK8 | STAT6 | Ser707 | IPPYQGLsPEESVNV | phosphorylation down-regulates | 21123173 | SIGNOR-170153 |
| MAPK8 | ATF2 | Thr69 | SVIVADQtPTPTRFL | phosphorylation up-regulates | 7737130 | SIGNOR-32421 |
| MAPK8 | MYC | Ser62 | LLPTPPLsPSRRSGL | phosphorylation up-regulates activity | 10551811 | SIGNOR-236018 |
| MAPK8 | RXRA | Ser260 | NMGLNPSsPNDPVTN | phosphorylation down-regulates activity | 16551633 | SIGNOR-145297 |
| MAPK8 | BCL2L11 | Thr116 | SCDKSTQtPSPPCQA | phosphorylation up-regulates | 12591950 | SIGNOR-98396 |
| MAPK8 | PPARG | Ser112 | AIKVEPAsPPYYSEK | phosphorylation down-regulates activity | 9030579 | SIGNOR-46518 |
| MAPK8 | APP | Thr743 | VEVDAAVtPEERHLS | phosphorylation up-regulates | 12917434 | SIGNOR-117852 |
| MAPK8 | FOXO | Thr455 | ALGTPVLtPPTEAAS | phosphorylation up-regulates | 15538382 | SIGNOR-252965 |
| MAPK8 | BCL2 | Thr69 | SRDPVARtSPLQTPA | phosphorylation down-regulates | 10567572 | SIGNOR-72361 |
| MAPK8 | CDKN1A | Ser130 | SGEQAEGsPGGPGDS | phosphorylation up-regulates quantity by stabilization | 12058028 | SIGNOR-89440 |
| MAPK8 | APLP2 | Thr736 | VEVDPMLtPEERHLN | phosphorylation up-regulates | 14970211 | SIGNOR-122196 |
| MAPK8 | NFATC3 | – | phosphorylation down-regulates | 14517246 | SIGNOR-118220 | |
| MAPK8 | BAD | – | phosphorylation down-regulates | 14967141 | SIGNOR-121940 | |
| MAPK8 | BCL2L11 | – | phosphorylation up-regulates | 18498746 | SIGNOR-178686 | |
| MAPK8 | NR3C1 | Ser226 | IDENCLLsPLAGEDD | phosphorylation down-regulates | 12351702 | SIGNOR-93558 |
| MAPK8 | MAPK8IP3 | Thr286 | SVPSAAVtPLNESLQ | phosphorylation up-regulates | 15767678 | SIGNOR-134549 |
| MAPK8 | BCL2 | – | phosphorylation down-regulates | 10567572 | SIGNOR-72364 | |
| MAPK8 | BCL2 | Ser87 | AAAGPALsPVPPVVH | phosphorylation down-regulates activity | 18570871 | SIGNOR-179092 |
| MAPK8 | BCL2L11 | – | phosphorylation up-regulates | 12591950 | SIGNOR-98399 | |
| MAPK8 | EEF1A2 | Ser358 | GQISAGYsPVIDCHT | phosphorylation down-regulates quantity by destabilization | 23608534 | SIGNOR-276492 |
| MAPK8 | FOXO4 | Thr451 | PIPKALGtPVLTPPT | phosphorylation up-regulates | 15538382 | SIGNOR-130381 |
| MAPK8 | ATF2 | Thr71 | IVADQTPtPTRFLKN | phosphorylation up-regulates | 7824938 | SIGNOR-33918 |
| MAPK8 | HNRNPK | Ser216 | ILDLISEsPIKGRAQ | phosphorylation up-regulates | 11259409 | SIGNOR-105766 |
| MAPK8 | H2AX | Ser140 | GKKATQAsQEY | phosphorylation up-regulates | 19234442 | SIGNOR-184146 |
| MAPK8 | GRB7 | Ser194 | KYELFKSsPHSLFPE | phosphorylation down-regulates quantity by destabilization | 27658202 | SIGNOR-277280 |
| MAPK8 | DCX | – | phosphorylation up-regulates activity | 21477071 | SIGNOR-279217 | |
| MAPK8 | TWIST1 | Ser68 | GGGDEPGsPAQGKRG | phosphorylation up-regulates | 21502402 | SIGNOR-173417 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | phosphorylation up-regulates → | AIMP1 PSer140 | phosphorylation down-regulates ⊣ | AIMP1 | 20510162 | SIGNOR-165763 |
| MAPK8 | phosphorylation up-regulates → | MAPK8IP3 PThr265 | phosphorylation up-regulates → | MAPK8IP3 | 15767678 | SIGNOR-134541 |
| MAPK8 | phosphorylation up-regulates → | JUNB PThr102 | phosphorylation up-regulates → | JUNB | 9889198 | SIGNOR-250120 |
| MAPK8 | phosphorylation up-regulates → | FOXO3 PSer574 | phosphorylation up-regulates → | FOXO3 | 27669435 | SIGNOR-280030 |
| MAPK8 | phosphorylation up-regulates → | NFATC4 PSer213 | phosphorylation up-regulates → | NFATC4 | 17875713 | SIGNOR-280032 |
| MAPK8 | phosphorylation up-regulates → | NFATC4 PSer217 | phosphorylation up-regulates → | NFATC4 | 17875713 | SIGNOR-280033 |
| MAPK8 | phosphorylation up-regulates → | SP1 PThr278 | phosphorylation up-regulates → | SP1 | 19245816 | SIGNOR-184190 |
| MAPK8 | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 11896587 | SIGNOR-106538 |
| MAPK8 | phosphorylation up-regulates → | NEIL1 PSer61 | phosphorylation up-regulates → | NEIL1 | 27518429 | SIGNOR-278317 |
| MAPK8 | phosphorylation up-regulates → | EIF4ENIF1 PSer693 | phosphorylation up-regulates → | EIF4ENIF1 | 22966201 | SIGNOR-199000 |
| MAPK8 | phosphorylation up-regulates → | HSF1 PSer363 | phosphorylation down-regulates ⊣ | HSF1 | 10747973 | SIGNOR-250119 |
| MAPK8 | phosphorylation up-regulates → | AP1 PSer73 | phosphorylation up-regulates → | AP1 | 8137421 | SIGNOR-252355 |
| MAPK8 | phosphorylation up-regulates → | STK4 PSer82 | phosphorylation up-regulates → | STK4 | 20028971 | SIGNOR-162327 |
| MAPK8 | phosphorylation up-regulates → | MYC PSer71 | phosphorylation up-regulates → | MYC | 10551811 | SIGNOR-236384 |
| MAPK8 | phosphorylation up-regulates → | BCL2L11 PSer69 | phosphorylation down-regulates ⊣ | BCL2L11 | 18174237 | SIGNOR-160323 |
| MAPK8 | phosphorylation up-regulates → | CDKN1A PThr57 | phosphorylation up-regulates → | CDKN1A | 12058028 | SIGNOR-250118 |
| MAPK8 | phosphorylation up-regulates → | BCL2 PThr69 | phosphorylation down-regulates ⊣ | BCL2 | 18570871 | SIGNOR-179096 |
| MAPK8 | phosphorylation up-regulates → | NEIL1 PSer207 | phosphorylation up-regulates → | NEIL1 | 27518429 | SIGNOR-278316 |
| MAPK8 | phosphorylation up-regulates → | EIF4ENIF1 PSer513 | phosphorylation up-regulates → | EIF4ENIF1 | 22966201 | SIGNOR-198992 |
| MAPK8 | phosphorylation up-regulates → | JUNB PThr104 | phosphorylation up-regulates → | JUNB | 9889198 | SIGNOR-250121 |
| MAPK8 | phosphorylation up-regulates → | RCSD1 PSer216 | phosphorylation down-regulates ⊣ | RCSD1 | 15850461 | SIGNOR-263087 |
| MAPK8 | phosphorylation up-regulates → | APP PThr743 | phosphorylation up-regulates → | APP | 24610780 | SIGNOR-204679 |
| MAPK8 | phosphorylation up-regulates → | CTBP1 PSer422 | phosphorylation down-regulates ⊣ | CTBP1 | 16984892 | SIGNOR-149721 |
| MAPK8 | phosphorylation up-regulates → | AP1 PSer63 | phosphorylation up-regulates → | AP1 | 8137421 | SIGNOR-252354 |
| MAPK8 | phosphorylation up-regulates → | IRS1 PSer616 | phosphorylation down-regulates ⊣ | IRS1 | 12510059 | SIGNOR-96944 |
| MAPK8 | phosphorylation up-regulates → | BID PThr59 | phosphorylation up-regulates → | BID | 25077544 | SIGNOR-279076 |
| MAPK8 | phosphorylation up-regulates → | MAPK8IP1 PSer421 | phosphorylation down-regulates ⊣ | MAPK8IP1 | 12756254 | SIGNOR-250126 |
| MAPK8 | phosphorylation up-regulates → | KRT8 PSer74 | phosphorylation up-regulates → | KRT8 | 11781324 | SIGNOR-113645 |
| MAPK8 | phosphorylation up-regulates → | ELK1 PSer389 | phosphorylation up-regulates → | ELK1 | 7651411 | SIGNOR-236432 |
| MAPK8 | phosphorylation up-regulates → | DIABLO PSer6 | phosphorylation up-regulates → | DIABLO | 25310587 | SIGNOR-280029 |
| MAPK8 | phosphorylation up-regulates → | NEIL1 PSer306 | phosphorylation up-regulates → | NEIL1 | 27518429 | SIGNOR-278315 |
| MAPK8 | phosphorylation up-regulates → | SP1 PThr739 | phosphorylation up-regulates → | SP1 | 19245816 | SIGNOR-184194 |
| MAPK8 | phosphorylation up-regulates → | STMN1 PSer38 | phosphorylation down-regulates ⊣ | STMN1 | 20630875 | SIGNOR-166694 |
| MAPK8 | phosphorylation up-regulates → | KRT8 PSer74 | phosphorylation up-regulates → | KRT8 | 11788583 | SIGNOR-114083 |
| MAPK8 | phosphorylation up-regulates → | PXN PSer178 | phosphorylation up-regulates → | PXN | 12853963 | SIGNOR-250129 |
| MAPK8 | phosphorylation up-regulates → | IRS1 PSer315 | phosphorylation down-regulates ⊣ | IRS1 | 12510059 | SIGNOR-96940 |
| MAPK8 | phosphorylation up-regulates → | FOXO PThr451 | phosphorylation up-regulates → | FOXO | 15538382 | SIGNOR-252964 |
| MAPK8 | phosphorylation up-regulates → | RCSD1 PSer68 | phosphorylation down-regulates ⊣ | RCSD1 | 15850461 | SIGNOR-263085 |
| MAPK8 | phosphorylation up-regulates → | MAPK8IP1 PSer197 | phosphorylation down-regulates ⊣ | MAPK8IP1 | 12756254 | SIGNOR-250124 |
| MAPK8 | phosphorylation up-regulates → | IRS1 PSer636 | phosphorylation down-regulates ⊣ | IRS1 | 12510059 | SIGNOR-96948 |
| MAPK8 | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 11896587 | SIGNOR-115831 |
| MAPK8 | phosphorylation up-regulates → | ATF2 PThr71 | phosphorylation up-regulates → | ATF2 | 7737130 | SIGNOR-32425 |
| MAPK8 | phosphorylation up-regulates → | ELK1 PSer383 | phosphorylation up-regulates → | ELK1 | 8846788 | SIGNOR-44356 |
| MAPK8 | phosphorylation up-regulates → | SIRT1 PSer47 | phosphorylation up-regulates → | SIRT1 | 20027304 | SIGNOR-162318 |
| MAPK8 | phosphorylation up-regulates → | EIF4ENIF1 PSer752 | phosphorylation up-regulates → | EIF4ENIF1 | 22966201 | SIGNOR-199004 |
| MAPK8 | phosphorylation up-regulates → | HNRNPK PSer353 | phosphorylation up-regulates → | HNRNPK | 11259409 | SIGNOR-105251 |
| MAPK8 | phosphorylation up-regulates → | IRF3 PSer173 | phosphorylation up-regulates → | IRF3 | 19153595 | SIGNOR-183489 |
| MAPK8 | phosphorylation up-regulates → | MAPK8IP1 PThr205 | phosphorylation down-regulates ⊣ | MAPK8IP1 | 12756254 | SIGNOR-250127 |
| MAPK8 | phosphorylation up-regulates → | PIN1 PSer115 | phosphorylation up-regulates → | PIN1 | 34048060 | SIGNOR-277562 |
| MAPK8 | phosphorylation up-regulates → | EIF4ENIF1 PSer301 | phosphorylation up-regulates → | EIF4ENIF1 | 22966201 | SIGNOR-198984 |
| MAPK8 | phosphorylation up-regulates → | CDC25B PSer103 | phosphorylation down-regulates ⊣ | CDC25B | 21807946 | SIGNOR-276351 |
| MAPK8 | phosphorylation up-regulates → | BCL2 PSer87 | phosphorylation down-regulates ⊣ | BCL2 | 10567572 | SIGNOR-48038 |
| MAPK8 | phosphorylation up-regulates → | IRS1 PSer312 | phosphorylation down-regulates ⊣ | IRS1 | 12510059 | SIGNOR-236591 |
| MAPK8 | phosphorylation up-regulates → | CDT1 PThr29 | phosphorylation down-regulates ⊣ | CDT1 | 21856198 | SIGNOR-278445 |
| MAPK8 | phosphorylation up-regulates → | PKM PThr365 | phosphorylation up-regulates → | PKM | 26258887 | SIGNOR-276933 |
| MAPK8 | phosphorylation up-regulates → | MAPK8IP1 PSer15 | phosphorylation down-regulates ⊣ | MAPK8IP1 | 12756254 | SIGNOR-250123 |
| MAPK8 | phosphorylation up-regulates → | ARHGAP8 PSer455 | phosphorylation up-regulates → | ARHGAP8 | 28092672 | SIGNOR-275550 |
| MAPK8 | phosphorylation up-regulates → | IRS1 PSer312 | phosphorylation down-regulates ⊣ | IRS1 | 18728222 | SIGNOR-180532 |
| MAPK8 | phosphorylation up-regulates → | CDC25C PSer168 | phosphorylation down-regulates ⊣ | CDC25C | 20220133 | SIGNOR-164089 |
| MAPK8 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 23255093 | SIGNOR-235704 |
| MAPK8 | phosphorylation up-regulates → | MAPK8IP3 PThr275 | phosphorylation up-regulates → | MAPK8IP3 | 15767678 | SIGNOR-134545 |
| MAPK8 | phosphorylation up-regulates → | CDT1 PSer491 | phosphorylation up-regulates → | CDT1 | 21930785 | SIGNOR-276360 |
| MAPK8 | phosphorylation up-regulates → | CDT1 PSer391 | phosphorylation up-regulates → | CDT1 | 21930785 | SIGNOR-276361 |
| MAPK8 | phosphorylation up-regulates → | RCSD1 PSer83 | phosphorylation down-regulates ⊣ | RCSD1 | 15850461 | SIGNOR-263086 |
| MAPK8 | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 24913968 | SIGNOR-251101 |
| MAPK8 | phosphorylation up-regulates → | NR4A1 PSer95 | phosphorylation down-regulates ⊣ | NR4A1 | 17023523 | SIGNOR-149998 |
| MAPK8 | phosphorylation up-regulates → | TP53 PThr81 | phosphorylation up-regulates → | TP53 | 12531896 | SIGNOR-97405 |
| MAPK8 | phosphorylation up-regulates → | SARM1 PSer548 | phosphorylation down-regulates ⊣ | SARM1 | 30333228 | SIGNOR-275554 |
| MAPK8 | phosphorylation up-regulates → | SIRT1 PSer27 | phosphorylation up-regulates → | SIRT1 | 20027304 | SIGNOR-162314 |
| MAPK8 | phosphorylation up-regulates → | MAPK8IP1 PSer29 | phosphorylation down-regulates ⊣ | MAPK8IP1 | 12756254 | SIGNOR-250125 |
| MAPK8 | phosphorylation up-regulates → | CDC25B PSer101 | phosphorylation down-regulates ⊣ | CDC25B | 21807946 | SIGNOR-276352 |
| MAPK8 | phosphorylation up-regulates → | ITCH PSer273 | phosphorylation up-regulates → | ITCH | 16446428 | SIGNOR-249580 |
| MAPK8 | phosphorylation up-regulates → | EEF1A2 PSer205 | phosphorylation down-regulates ⊣ | EEF1A2 | 23608534 | SIGNOR-276491 |
| MAPK8 | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 8137421 | SIGNOR-250122 |
| MAPK8 | phosphorylation up-regulates → | ATF2 PThr69 | phosphorylation up-regulates → | ATF2 | 7824938 | SIGNOR-33914 |
| MAPK8 | phosphorylation up-regulates → | BCL2L1 PSer62 | phosphorylation down-regulates ⊣ | BCL2L1 | 12633850 | SIGNOR-99219 |
| MAPK8 | phosphorylation up-regulates → | MCL1 PThr163 | phosphorylation up-regulates → | MCL1 | 12223490 | SIGNOR-92597 |
| MAPK8 | phosphorylation up-regulates → | WDR62 PThr1053 | phosphorylation down-regulates ⊣ | WDR62 | 30566428 | SIGNOR-271710 |
| MAPK8 | phosphorylation up-regulates → | JUND PSer100 | phosphorylation up-regulates → | JUND | 22327296 | SIGNOR-196038 |
| MAPK8 | phosphorylation up-regulates → | ATN1 PSer739 | phosphorylation down-regulates ⊣ | ATN1 | 12812981 | SIGNOR-102398 |
| MAPK8 | phosphorylation up-regulates → | BCL2 PSer70 | phosphorylation up-regulates → | BCL2 | 18570871 | SIGNOR-179088 |
| MAPK8 | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 8137421 | SIGNOR-235766 |
| MAPK8 | phosphorylation up-regulates → | SIRT1 PThr530 | phosphorylation up-regulates → | SIRT1 | 20027304 | SIGNOR-162322 |
| MAPK8 | phosphorylation up-regulates → | YWHAZ PSer184 | phosphorylation down-regulates ⊣ | YWHAZ | 15071501 | SIGNOR-124020 |
| MAPK8 | phosphorylation up-regulates → | PPM1J PSer93 | phosphorylation down-regulates ⊣ | PPM1J | 18553930 | SIGNOR-178930 |
| MAPK8 | phosphorylation up-regulates → | EIF4ENIF1 PSer587 | phosphorylation up-regulates → | EIF4ENIF1 | 22966201 | SIGNOR-198996 |
| MAPK8 | phosphorylation up-regulates → | IRS1 PSer307 | phosphorylation down-regulates ⊣ | IRS1 | 14579029 | SIGNOR-118857 |
| MAPK8 | phosphorylation up-regulates → | HNRNPK PSer353 | phosphorylation up-regulates → | HNRNPK | 11259409 | SIGNOR-105770 |
| MAPK8 | phosphorylation up-regulates → | SYT4 PSer135 | phosphorylation up-regulates → | SYT4 | 18046461 | SIGNOR-273673 |
| MAPK8 | phosphorylation up-regulates → | MAPK8IP1 PThr103 | phosphorylation up-regulates → | MAPK8IP1 | 12756254 | SIGNOR-250128 |
| MAPK8 | phosphorylation up-regulates → | ELK1 PSer389 | phosphorylation up-regulates → | ELK1 | 8846788 | SIGNOR-236455 |
| MAPK8 | phosphorylation up-regulates → | IRS1 PSer307 | phosphorylation down-regulates ⊣ | IRS1 | 12510059 | SIGNOR-96936 |
| MAPK8 | phosphorylation up-regulates → | BCL2 PSer70 | phosphorylation up-regulates → | BCL2 | 10567572 | SIGNOR-72125 |
| MAPK8 | phosphorylation up-regulates → | BCL2L11 PSer77 | phosphorylation up-regulates → | BCL2L11 | 12818176 | SIGNOR-250133 |
| MAPK8 | phosphorylation up-regulates → | IRS1 PSer315 | phosphorylation down-regulates ⊣ | IRS1 | 14579029 | SIGNOR-118861 |
| MAPK8 | phosphorylation up-regulates → | FOXO4 PThr455 | phosphorylation up-regulates → | FOXO4 | 15538382 | SIGNOR-130385 |
| MAPK8 | phosphorylation up-regulates → | ITCH PSer240 | phosphorylation up-regulates → | ITCH | 16446428 | SIGNOR-245323 |
| MAPK8 | phosphorylation up-regulates → | TP53 PThr81 | phosphorylation up-regulates → | TP53 | 11283254 | SIGNOR-106542 |
| MAPK8 | phosphorylation up-regulates → | MFN2 PSer27 | phosphorylation down-regulates ⊣ | MFN2 | 22748923 | SIGNOR-274138 |
| MAPK8 | phosphorylation up-regulates → | LAT PThr184 | phosphorylation down-regulates ⊣ | LAT | 15192708 | SIGNOR-125774 |
| MAPK8 | phosphorylation up-regulates → | BCL2L11 PSer69 | phosphorylation down-regulates ⊣ | BCL2L11 | 15486195 | SIGNOR-250132 |
| MAPK8 | phosphorylation up-regulates → | YWHAB PSer186 | phosphorylation down-regulates ⊣ | YWHAB | 15696159 | SIGNOR-133875 |
| MAPK8 | phosphorylation up-regulates → | AKT1 PThr450 | phosphorylation up-regulates → | AKT1 | 16306447 | SIGNOR-252426 |
| MAPK8 | phosphorylation up-regulates → | HNRNPK PSer216 | phosphorylation up-regulates → | HNRNPK | 11259409 | SIGNOR-105247 |
| MAPK8 | phosphorylation up-regulates → | NLRP3 PSer198 | phosphorylation up-regulates → | NLRP3 | 28943315 | SIGNOR-277324 |
| MAPK8 | phosphorylation up-regulates → | MCL1 PThr163 | phosphorylation up-regulates → | MCL1 | 18676833 | SIGNOR-179816 |
| MAPK8 | phosphorylation up-regulates → | SFN PSer186 | phosphorylation down-regulates ⊣ | SFN | 15071501 | SIGNOR-124016 |
| MAPK8 | phosphorylation up-regulates → | EIF4ENIF1 PSer374 | phosphorylation up-regulates → | EIF4ENIF1 | 22966201 | SIGNOR-198988 |
| MAPK8 | phosphorylation up-regulates → | NFE2 PSer157 | phosphorylation down-regulates ⊣ | NFE2 | 19966288 | SIGNOR-275552 |
| MAPK8 | phosphorylation up-regulates → | ITCH PThr263 | phosphorylation up-regulates → | ITCH | 16446428 | SIGNOR-249579 |
| MAPK8 | phosphorylation up-regulates → | STAT6 PSer707 | phosphorylation down-regulates ⊣ | STAT6 | 21123173 | SIGNOR-170153 |
| MAPK8 | phosphorylation up-regulates → | ATF2 PThr69 | phosphorylation up-regulates → | ATF2 | 7737130 | SIGNOR-32421 |
| MAPK8 | phosphorylation up-regulates → | MYC PSer62 | phosphorylation up-regulates → | MYC | 10551811 | SIGNOR-236018 |
| MAPK8 | phosphorylation up-regulates → | RXRA PSer260 | phosphorylation down-regulates ⊣ | RXRA | 16551633 | SIGNOR-145297 |
| MAPK8 | phosphorylation up-regulates → | BCL2L11 PThr116 | phosphorylation up-regulates → | BCL2L11 | 12591950 | SIGNOR-98396 |
| MAPK8 | phosphorylation up-regulates → | PPARG PSer112 | phosphorylation down-regulates ⊣ | PPARG | 9030579 | SIGNOR-46518 |
| MAPK8 | phosphorylation up-regulates → | APP PThr743 | phosphorylation up-regulates → | APP | 12917434 | SIGNOR-117852 |
| MAPK8 | phosphorylation up-regulates → | FOXO PThr455 | phosphorylation up-regulates → | FOXO | 15538382 | SIGNOR-252965 |
| MAPK8 | phosphorylation up-regulates → | BCL2 PThr69 | phosphorylation down-regulates ⊣ | BCL2 | 10567572 | SIGNOR-72361 |
| MAPK8 | phosphorylation up-regulates → | CDKN1A PSer130 | phosphorylation up-regulates → | CDKN1A | 12058028 | SIGNOR-89440 |
| MAPK8 | phosphorylation up-regulates → | APLP2 PThr736 | phosphorylation up-regulates → | APLP2 | 14970211 | SIGNOR-122196 |
| MAPK8 | phosphorylation up-regulates → | NR3C1 PSer226 | phosphorylation down-regulates ⊣ | NR3C1 | 12351702 | SIGNOR-93558 |
| MAPK8 | phosphorylation up-regulates → | MAPK8IP3 PThr286 | phosphorylation up-regulates → | MAPK8IP3 | 15767678 | SIGNOR-134549 |
| MAPK8 | phosphorylation up-regulates → | BCL2 PSer87 | phosphorylation down-regulates ⊣ | BCL2 | 18570871 | SIGNOR-179092 |
| MAPK8 | phosphorylation up-regulates → | EEF1A2 PSer358 | phosphorylation down-regulates ⊣ | EEF1A2 | 23608534 | SIGNOR-276492 |
| MAPK8 | phosphorylation up-regulates → | FOXO4 PThr451 | phosphorylation up-regulates → | FOXO4 | 15538382 | SIGNOR-130381 |
| MAPK8 | phosphorylation up-regulates → | ATF2 PThr71 | phosphorylation up-regulates → | ATF2 | 7824938 | SIGNOR-33918 |
| MAPK8 | phosphorylation up-regulates → | HNRNPK PSer216 | phosphorylation up-regulates → | HNRNPK | 11259409 | SIGNOR-105766 |
| MAPK8 | phosphorylation up-regulates → | H2AX PSer140 | phosphorylation up-regulates → | H2AX | 19234442 | SIGNOR-184146 |
| MAPK8 | phosphorylation up-regulates → | GRB7 PSer194 | phosphorylation down-regulates ⊣ | GRB7 | 27658202 | SIGNOR-277280 |
| MAPK8 | phosphorylation up-regulates → | TWIST1 PSer68 | phosphorylation up-regulates → | TWIST1 | 21502402 | SIGNOR-173417 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK8 | phosphorylation down-regulates | AIMP1 | SIGNOR-165763 |
| MAPK8 | phosphorylation → up-regulates | MAPK8IP3 | SIGNOR-134541 |
| MAPK8 | phosphorylation → up-regulates activity | JUNB | SIGNOR-250120 |
| MAPK8 | phosphorylation → up-regulates activity | FOXO3 | SIGNOR-280030 |
| MAPK8 | phosphorylation → down-regulates activity | NFATC1 | SIGNOR-280031 |
| MAPK8 | phosphorylation → up-regulates activity | NFATC4 | SIGNOR-280032 |
| MAPK8 | phosphorylation → up-regulates activity | NFATC4 | SIGNOR-280033 |
| MAPK8 | phosphorylation → up-regulates activity | NLRP3 | SIGNOR-280034 |
| MAPK8 | phosphorylation → up-regulates | SP1 | SIGNOR-184190 |
| MAPK8 | phosphorylation → up-regulates activity | TP53 | SIGNOR-106538 |
| MAPK8 | phosphorylation → up-regulates activity | NEIL1 | SIGNOR-278317 |
| MAPK8 | phosphorylation → up-regulates | EIF4ENIF1 | SIGNOR-199000 |
| MAPK8 | phosphorylation → down-regulates activity | HSF1 | SIGNOR-250119 |
| MAPK8 | phosphorylation → up-regulates activity | AP1 | SIGNOR-252355 |
| MAPK8 | phosphorylation → up-regulates | STK4 | SIGNOR-162327 |
| MAPK8 | phosphorylation → up-regulates activity | MYC | SIGNOR-236384 |
| MAPK8 | phosphorylation down-regulates quantity by destabilization | BCL2L11 | SIGNOR-160323 |
| MAPK8 | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-250118 |
| MAPK8 | phosphorylation down-regulates | BCL2 | SIGNOR-179096 |
| MAPK8 | phosphorylation → up-regulates activity | NEIL1 | SIGNOR-278316 |
| MAPK8 | phosphorylation → up-regulates | EIF4ENIF1 | SIGNOR-198992 |
| MAPK8 | phosphorylation down-regulates | BCL2L11 | SIGNOR-160326 |
| MAPK8 | phosphorylation → up-regulates activity | JUNB | SIGNOR-250121 |
| MAPK8 | phosphorylation → up-regulates activity | TP73 | SIGNOR-279219 |
| MAPK8 | phosphorylation → down-regulates activity | RCSD1 | SIGNOR-263087 |
| MAPK8 | phosphorylation → up-regulates | APP | SIGNOR-204679 |
| MAPK8 | phosphorylation down-regulates | CTBP1 | SIGNOR-149721 |
| MAPK8 | phosphorylation → up-regulates activity | AP1 | SIGNOR-252354 |
| MAPK8 | phosphorylation → down-regulates activity | IRS1 | SIGNOR-96944 |
| MAPK8 | phosphorylation → up-regulates activity | BID | SIGNOR-279076 |
| MAPK8 | phosphorylation → unknown | MAPK8IP1 | SIGNOR-250126 |
| MAPK8 | phosphorylation → up-regulates | KRT8 | SIGNOR-113645 |
| MAPK8 | phosphorylation → up-regulates activity | ELK1 | SIGNOR-236432 |
| MAPK8 | phosphorylation → up-regulates activity | DIABLO | SIGNOR-280029 |
| MAPK8 | phosphorylation → up-regulates activity | NEIL1 | SIGNOR-278315 |
| MAPK8 | phosphorylation → up-regulates | SP1 | SIGNOR-184194 |
| MAPK8 | phosphorylation down-regulates | STMN1 | SIGNOR-166694 |
| MAPK8 | phosphorylation → up-regulates | KRT8 | SIGNOR-114083 |
| MAPK8 | phosphorylation → up-regulates | LRP6 | SIGNOR-169007 |
| MAPK8 | phosphorylation → up-regulates activity | PXN | SIGNOR-250129 |
| MAPK8 | phosphorylation down-regulates | IRS1 | SIGNOR-96940 |
| MAPK8 | phosphorylation → up-regulates | FOXO | SIGNOR-252964 |
| MAPK8 | phosphorylation → down-regulates activity | RCSD1 | SIGNOR-263085 |
| MAPK8 | phosphorylation → up-regulates activity | OSBP2 | SIGNOR-264876 |
| MAPK8 | phosphorylation → up-regulates activity | ITCH | SIGNOR-245315 |
| MAPK8 | phosphorylation → unknown | MAPK8IP1 | SIGNOR-250124 |
| MAPK8 | phosphorylation → down-regulates activity | IRS1 | SIGNOR-96948 |
| MAPK8 | phosphorylation → up-regulates | TP53 | SIGNOR-115831 |
| MAPK8 | phosphorylation → up-regulates | ATF2 | SIGNOR-32425 |
| MAPK8 | phosphorylation → up-regulates | ELK1 | SIGNOR-44356 |
| MAPK8 | phosphorylation → up-regulates | SIRT1 | SIGNOR-162318 |
| MAPK8 | phosphorylation → up-regulates | EIF4ENIF1 | SIGNOR-199004 |
| MAPK8 | phosphorylation → up-regulates activity | HNRNPK | SIGNOR-105251 |
| MAPK8 | phosphorylation → up-regulates | IRF3 | SIGNOR-183489 |
| MAPK8 | phosphorylation → unknown | MAPK8IP1 | SIGNOR-250127 |
| MAPK8 | phosphorylation → up-regulates quantity by stabilization | PIN1 | SIGNOR-277562 |
| MAPK8 | phosphorylation → up-regulates | EIF4ENIF1 | SIGNOR-198984 |
| MAPK8 | phosphorylation down-regulates quantity by destabilization | CDC25B | SIGNOR-276351 |
| MAPK8 | phosphorylation → down-regulates activity | BCL2 | SIGNOR-48038 |
| MAPK8 | phosphorylation down-regulates quantity by destabilization | IRS1 | SIGNOR-236591 |
| MAPK8 | phosphorylation → down-regulates activity | CDT1 | SIGNOR-278445 |
| MAPK8 | phosphorylation → up-regulates activity | PKM | SIGNOR-276933 |
| MAPK8 | phosphorylation → unknown | MAPK8IP1 | SIGNOR-250123 |
| MAPK8 | phosphorylation → up-regulates activity | ARHGAP8 | SIGNOR-275550 |
| MAPK8 | phosphorylation down-regulates | IRS1 | SIGNOR-180532 |
| MAPK8 | phosphorylation down-regulates | CDC25C | SIGNOR-164089 |
| MAPK8 | phosphorylation down-regulates | NFATC2 | SIGNOR-118217 |
| MAPK8 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-235704 |
| MAPK8 | phosphorylation → up-regulates | MAPK8IP3 | SIGNOR-134545 |
| MAPK8 | phosphorylation → up-regulates quantity by stabilization | CDT1 | SIGNOR-276360 |
| MAPK8 | phosphorylation → up-regulates activity | DCX | SIGNOR-279228 |
| MAPK8 | phosphorylation → up-regulates quantity by stabilization | CDT1 | SIGNOR-276361 |
| MAPK8 | phosphorylation → down-regulates activity | RCSD1 | SIGNOR-263086 |
| MAPK8 | phosphorylation → up-regulates activity | STAT1 | SIGNOR-251101 |
| MAPK8 | phosphorylation down-regulates | NR4A1 | SIGNOR-149998 |
| MAPK8 | phosphorylation → up-regulates | TP53 | SIGNOR-97405 |
| MAPK8 | phosphorylation → down-regulates activity | SARM1 | SIGNOR-275554 |
| MAPK8 | phosphorylation → up-regulates | SIRT1 | SIGNOR-162314 |
| MAPK8 | phosphorylation → unknown | MAPK8IP1 | SIGNOR-250125 |
| MAPK8 | phosphorylation → up-regulates activity | ITCH | SIGNOR-245310 |
| MAPK8 | phosphorylation → down-regulates activity | ELK3 | SIGNOR-250139 |
| MAPK8 | phosphorylation down-regulates quantity by destabilization | CDC25B | SIGNOR-276352 |
| MAPK8 | phosphorylation → up-regulates activity | ITCH | SIGNOR-249580 |
| MAPK8 | phosphorylation down-regulates quantity by destabilization | EEF1A2 | SIGNOR-276491 |
| MAPK8 | phosphorylation → up-regulates | TP53 | SIGNOR-59812 |
| MAPK8 | phosphorylation → up-regulates activity | JUN | SIGNOR-250122 |
| MAPK8 | phosphorylation → up-regulates | ATF2 | SIGNOR-33914 |
| MAPK8 | phosphorylation down-regulates | BCL2L1 | SIGNOR-99219 |
| MAPK8 | phosphorylation → up-regulates | MCL1 | SIGNOR-92597 |
| MAPK8 | phosphorylation down-regulates quantity by destabilization | WDR62 | SIGNOR-271710 |
| MAPK8 | phosphorylation → down-regulates activity | E2F1 | SIGNOR-279218 |
| MAPK8 | phosphorylation → up-regulates | JUND | SIGNOR-196038 |
| MAPK8 | phosphorylation → down-regulates activity | ATN1 | SIGNOR-102398 |
| MAPK8 | phosphorylation → up-regulates | BCL2 | SIGNOR-179088 |
| MAPK8 | phosphorylation → up-regulates activity | JUN | SIGNOR-235766 |
| MAPK8 | phosphorylation → up-regulates | SIRT1 | SIGNOR-162322 |
| MAPK8 | phosphorylation down-regulates | YWHAZ | SIGNOR-124020 |
| MAPK8 | phosphorylation down-regulates | PPM1J | SIGNOR-178930 |
| MAPK8 | phosphorylation → up-regulates | EIF4ENIF1 | SIGNOR-198996 |
| MAPK8 | phosphorylation down-regulates | IRS1 | SIGNOR-118857 |
| MAPK8 | phosphorylation → up-regulates | HNRNPK | SIGNOR-105770 |
| MAPK8 | phosphorylation → up-regulates activity | SYT4 | SIGNOR-273673 |
| MAPK8 | phosphorylation → up-regulates activity | MAPK8IP1 | SIGNOR-250128 |
| MAPK8 | phosphorylation → up-regulates activity | ELK1 | SIGNOR-236455 |
| MAPK8 | phosphorylation down-regulates | IRS1 | SIGNOR-96936 |
| MAPK8 | phosphorylation → up-regulates | BCL2 | SIGNOR-72125 |
| MAPK8 | phosphorylation → up-regulates activity | BCL2L11 | SIGNOR-250133 |
| MAPK8 | phosphorylation down-regulates | IRS1 | SIGNOR-118861 |
| MAPK8 | phosphorylation → up-regulates | FOXO4 | SIGNOR-130385 |
| MAPK8 | phosphorylation → up-regulates activity | ITCH | SIGNOR-245323 |
| MAPK8 | phosphorylation → up-regulates | PKMYT1 | SIGNOR-183899 |
| MAPK8 | phosphorylation → up-regulates | MAPK9 | SIGNOR-155205 |
| MAPK8 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-106542 |
| MAPK8 | phosphorylation → down-regulates quantity | MFN2 | SIGNOR-274138 |
| MAPK8 | phosphorylation down-regulates | LAT | SIGNOR-125774 |
| MAPK8 | phosphorylation → up-regulates activity | BMF | SIGNOR-250116 |
| MAPK8 | phosphorylation down-regulates quantity by destabilization | BCL2L11 | SIGNOR-250132 |
| MAPK8 | phosphorylation down-regulates | YWHAB | SIGNOR-133875 |
| MAPK8 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252426 |
| MAPK8 | phosphorylation → up-regulates activity | HNRNPK | SIGNOR-105247 |
| MAPK8 | phosphorylation → up-regulates activity | NLRP3 | SIGNOR-277324 |
| MAPK8 | phosphorylation → up-regulates | ITCH | SIGNOR-144456 |
| MAPK8 | phosphorylation → up-regulates | MCL1 | SIGNOR-179816 |
| MAPK8 | phosphorylation down-regulates | SFN | SIGNOR-124016 |
| MAPK8 | phosphorylation → up-regulates | EIF4ENIF1 | SIGNOR-198988 |
| MAPK8 | phosphorylation down-regulates quantity by destabilization | NFE2 | SIGNOR-275552 |
| MAPK8 | phosphorylation → up-regulates activity | ITCH | SIGNOR-249579 |
| MAPK8 | phosphorylation down-regulates | STAT6 | SIGNOR-170153 |
| MAPK8 | phosphorylation → up-regulates | ATF2 | SIGNOR-32421 |
| MAPK8 | phosphorylation → up-regulates activity | MYC | SIGNOR-236018 |
| MAPK8 | phosphorylation → down-regulates activity | RXRA | SIGNOR-145297 |
| MAPK8 | phosphorylation → up-regulates | BCL2L11 | SIGNOR-98396 |
| MAPK8 | phosphorylation → down-regulates activity | PPARG | SIGNOR-46518 |
| MAPK8 | phosphorylation → up-regulates | APP | SIGNOR-117852 |
| MAPK8 | phosphorylation → up-regulates | FOXO | SIGNOR-252965 |
| MAPK8 | phosphorylation down-regulates | BCL2 | SIGNOR-72361 |
| MAPK8 | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-89440 |
| MAPK8 | phosphorylation → up-regulates | APLP2 | SIGNOR-122196 |
| MAPK8 | phosphorylation down-regulates | NFATC3 | SIGNOR-118220 |
| MAPK8 | phosphorylation down-regulates | BAD | SIGNOR-121940 |
| MAPK8 | phosphorylation → up-regulates | BCL2L11 | SIGNOR-178686 |
| MAPK8 | phosphorylation down-regulates | NR3C1 | SIGNOR-93558 |
| MAPK8 | phosphorylation → up-regulates | MAPK8IP3 | SIGNOR-134549 |
| MAPK8 | phosphorylation down-regulates | BCL2 | SIGNOR-72364 |
| MAPK8 | phosphorylation → down-regulates activity | BCL2 | SIGNOR-179092 |
| MAPK8 | phosphorylation → up-regulates | BCL2L11 | SIGNOR-98399 |
| MAPK8 | phosphorylation down-regulates quantity by destabilization | EEF1A2 | SIGNOR-276492 |
| MAPK8 | phosphorylation → up-regulates | FOXO4 | SIGNOR-130381 |
| MAPK8 | phosphorylation → up-regulates | ATF2 | SIGNOR-33918 |
| MAPK8 | phosphorylation → up-regulates | HNRNPK | SIGNOR-105766 |
| MAPK8 | phosphorylation → up-regulates | H2AX | SIGNOR-184146 |
| MAPK8 | phosphorylation down-regulates quantity by destabilization | GRB7 | SIGNOR-277280 |
| MAPK8 | phosphorylation → up-regulates activity | DCX | SIGNOR-279217 |
| MAPK8 | phosphorylation → up-regulates | TWIST1 | SIGNOR-173417 |