| Name | MAPK8 |
| ID | P45983 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 26-321 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PBK | MAPK8 | – | phosphorylation up-regulates activity | 17545598 | SIGNOR-280061 | |
| DUSP6 | MAPK8 | – | dephosphorylation down-regulates activity | 24861519 | SIGNOR-277150 | |
| DUSP19 | MAPK8 | – | dephosphorylation down-regulates | 11959861 | SIGNOR-117260 | |
| DUSP4 | MAPK8 | – | dephosphorylation down-regulates | 9020184 | SIGNOR-27756 | |
| MAP2K7 | MAPK8 | Thr183 | AGTSFMMtPYVVTRY | phosphorylation up-regulates | 9312068 | SIGNOR-51199 |
| PRKCD | MAPK8 | – | phosphorylation up-regulates | 17183360 | SIGNOR-151428 | |
| IL1R1 | MAPK8 | – | phosphorylation up-regulates activity | 9625767 | SIGNOR-249513 | |
| MAP2K7 | MAPK8 | Thr183 | AGTSFMMtPYVVTRY | phosphorylation up-regulates | 11062067 | SIGNOR-83736 |
| MAP2K4 | MAPK8 | Tyr185 | TSFMMTPyVVTRYYR | phosphorylation up-regulates activity | 9724739 | SIGNOR-249654 |
| ROCK1 | MAPK8 | – | phosphorylation up-regulates activity | 15068801 | SIGNOR-123717 | |
| DUSP10 | MAPK8 | – | dephosphorylation down-regulates | 10391943 | SIGNOR-68986 | |
| MAP2K7 | MAPK8 | Tyr185 | TSFMMTPyVVTRYYR | phosphorylation up-regulates | 9312068 | SIGNOR-51203 |
| MAP2K4 | MAPK8 | Tyr185 | TSFMMTPyVVTRYYR | phosphorylation up-regulates activity | 11062067 | SIGNOR-251419 |
| MAP2K4 | MAPK8 | Thr183 | AGTSFMMtPYVVTRY | phosphorylation up-regulates activity | 9724739 | SIGNOR-244982 |
| DUSP1 | MAPK8 | – | dephosphorylation down-regulates | 9020184 | SIGNOR-46079 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP2K7 | phosphorylation up-regulates → | MAPK8 PThr183 | phosphorylation up-regulates → | MAPK8 | 9312068 | SIGNOR-51199 |
| MAP2K7 | phosphorylation up-regulates → | MAPK8 PThr183 | phosphorylation up-regulates → | MAPK8 | 11062067 | SIGNOR-83736 |
| MAP2K4 | phosphorylation up-regulates → | MAPK8 PTyr185 | phosphorylation up-regulates → | MAPK8 | 9724739 | SIGNOR-249654 |
| MAP2K7 | phosphorylation up-regulates → | MAPK8 PTyr185 | phosphorylation up-regulates → | MAPK8 | 9312068 | SIGNOR-51203 |
| MAP2K4 | phosphorylation up-regulates → | MAPK8 PTyr185 | phosphorylation up-regulates → | MAPK8 | 11062067 | SIGNOR-251419 |
| MAP2K4 | phosphorylation up-regulates → | MAPK8 PThr183 | phosphorylation up-regulates → | MAPK8 | 9724739 | SIGNOR-244982 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PBK | phosphorylation → up-regulates activity | MAPK8 | SIGNOR-280061 |
| DUSP6 | dephosphorylation → down-regulates activity | MAPK8 | SIGNOR-277150 |
| DUSP19 | dephosphorylation down-regulates | MAPK8 | SIGNOR-117260 |
| DUSP4 | dephosphorylation down-regulates | MAPK8 | SIGNOR-27756 |
| MAP2K7 | phosphorylation → up-regulates | MAPK8 | SIGNOR-51199 |
| PRKCD | phosphorylation → up-regulates | MAPK8 | SIGNOR-151428 |
| IL1R1 | phosphorylation → up-regulates activity | MAPK8 | SIGNOR-249513 |
| MAP2K7 | phosphorylation → up-regulates | MAPK8 | SIGNOR-83736 |
| MAP2K4 | phosphorylation → up-regulates activity | MAPK8 | SIGNOR-249654 |
| ROCK1 | phosphorylation → up-regulates activity | MAPK8 | SIGNOR-123717 |
| DUSP10 | dephosphorylation down-regulates | MAPK8 | SIGNOR-68986 |
| MAP2K7 | phosphorylation → up-regulates | MAPK8 | SIGNOR-51203 |
| MAP2K4 | phosphorylation → up-regulates activity | MAPK8 | SIGNOR-251419 |
| MAP2K4 | phosphorylation → up-regulates activity | MAPK8 | SIGNOR-244982 |
| DUSP1 | dephosphorylation down-regulates | MAPK8 | SIGNOR-46079 |