Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
ABL2	CRK	–		phosphorylation down-regulates	15886098	SIGNOR-136958
MAP2K6	CRK	–		phosphorylation up-regulates	8663074	SIGNOR-42384
ABL1	CRK	Tyr221 View in OncoXplorer	GGPEPGPyAQPSVNT	phosphorylation down-regulates activity	21779437	SIGNOR-175135
ABL2	CRK	Tyr221 View in OncoXplorer	GGPEPGPyAQPSVNT	phosphorylation down-regulates	15886098	SIGNOR-136955
IGF1R	CRK	Tyr221 View in OncoXplorer	GGPEPGPyAQPSVNT	phosphorylation down-regulates activity	9480911	SIGNOR-251273
EGFR	CRK	Tyr221 View in OncoXplorer	GGPEPGPyAQPSVNT	phosphorylation down-regulates activity	9642287	SIGNOR-251091
ABL1	CRK	Tyr221 View in OncoXplorer	GGPEPGPyAQPSVNT	phosphorylation down-regulates activity	21602891	SIGNOR-173845

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
ABL1	phosphorylation up-regulates →	CRK PTyr221	phosphorylation down-regulates ⊣	CRK	21779437	SIGNOR-175135
ABL2	phosphorylation up-regulates →	CRK PTyr221	phosphorylation down-regulates ⊣	CRK	15886098	SIGNOR-136955
IGF1R	phosphorylation up-regulates →	CRK PTyr221	phosphorylation down-regulates ⊣	CRK	9480911	SIGNOR-251273
EGFR	phosphorylation up-regulates →	CRK PTyr221	phosphorylation down-regulates ⊣	CRK	9642287	SIGNOR-251091
ABL1	phosphorylation up-regulates →	CRK PTyr221	phosphorylation down-regulates ⊣	CRK	21602891	SIGNOR-173845

Regulator	Mechanism/Effect	Target	SIGNOR-ID
ABL2	phosphorylation down-regulates	CRK	SIGNOR-136958
MAP2K6	phosphorylation → up-regulates	CRK	SIGNOR-42384
ABL1	phosphorylation → down-regulates activity	CRK	SIGNOR-175135
ABL2	phosphorylation down-regulates	CRK	SIGNOR-136955
IGF1R	phosphorylation → down-regulates activity	CRK	SIGNOR-251273
EGFR	phosphorylation → down-regulates activity	CRK	SIGNOR-251091
ABL1	phosphorylation → down-regulates activity	CRK	SIGNOR-173845