| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ABL1 | CRK | Tyr221 | GGPEPGPyAQPSVNT | phosphorylation down-regulates activity | 21602891 | SIGNOR-173845 |
| ABL1 | CRK | Tyr221 | GGPEPGPyAQPSVNT | phosphorylation down-regulates activity | 21779437 | SIGNOR-175135 |
| ABL2 | CRK | Tyr221 | GGPEPGPyAQPSVNT | phosphorylation down-regulates | 15886098 | SIGNOR-136955 |
| IGF1R | CRK | Tyr221 | GGPEPGPyAQPSVNT | phosphorylation down-regulates activity | 9480911 | SIGNOR-251273 |
| EGFR | CRK | Tyr221 | GGPEPGPyAQPSVNT | phosphorylation down-regulates activity | 9642287 | SIGNOR-251091 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ABL1 | phosphorylation up-regulates → | CRK PTyr221 | phosphorylation down-regulates ⊣ | CRK | 21602891 | SIGNOR-173845 |
| ABL1 | phosphorylation up-regulates → | CRK PTyr221 | phosphorylation down-regulates ⊣ | CRK | 21779437 | SIGNOR-175135 |
| ABL2 | phosphorylation up-regulates → | CRK PTyr221 | phosphorylation down-regulates ⊣ | CRK | 15886098 | SIGNOR-136955 |
| IGF1R | phosphorylation up-regulates → | CRK PTyr221 | phosphorylation down-regulates ⊣ | CRK | 9480911 | SIGNOR-251273 |
| EGFR | phosphorylation up-regulates → | CRK PTyr221 | phosphorylation down-regulates ⊣ | CRK | 9642287 | SIGNOR-251091 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ABL1 | phosphorylation → down-regulates activity | CRK | SIGNOR-173845 |
| ABL1 | phosphorylation → down-regulates activity | CRK | SIGNOR-175135 |
| ABL2 | phosphorylation down-regulates | CRK | SIGNOR-136955 |
| IGF1R | phosphorylation → down-regulates activity | CRK | SIGNOR-251273 |
| EGFR | phosphorylation → down-regulates activity | CRK | SIGNOR-251091 |
