Entity Details

Name NOTCH1
ID P46531
Role substrate
Enzymatic Domains
EGF-like 1 20-58
PROSITE-ProRule
EGF-like 2 59-99
PROSITE-ProRule
EGF-like 3 102-139
PROSITE-ProRule
EGF-like 4 140-176
PROSITE-ProRule
EGF-like 5; calcium-binding 178-216
PROSITE-ProRule
EGF-like 6 218-255
PROSITE-ProRule
EGF-like 7; calcium-binding 257-293
PROSITE-ProRule
EGF-like 8; calcium-binding 295-333
PROSITE-ProRule
EGF-like 9; calcium-binding 335-371
PROSITE-ProRule
EGF-like 10 372-410
PROSITE-ProRule
EGF-like 11; calcium-binding 412-450
PROSITE-ProRule
EGF-like 12; calcium-binding 452-488
PROSITE-ProRule
EGF-like 13; calcium-binding 490-526
PROSITE-ProRule
EGF-like 14; calcium-binding 528-564
PROSITE-ProRule
EGF-like 15; calcium-binding 566-601
PROSITE-ProRule
EGF-like 16; calcium-binding 603-639
PROSITE-ProRule
EGF-like 17; calcium-binding 641-676
PROSITE-ProRule
EGF-like 18; calcium-binding 678-714
PROSITE-ProRule
EGF-like 19; calcium-binding 716-751
PROSITE-ProRule
EGF-like 20 753-789
PROSITE-ProRule
EGF-like 21; calcium-binding 791-827
PROSITE-ProRule
EGF-like 22 829-867
PROSITE-ProRule
EGF-like 23; calcium-binding 869-905
PROSITE-ProRule
EGF-like 24 907-943
PROSITE-ProRule
EGF-like 25; calcium-binding 945-981
PROSITE-ProRule
EGF-like 26 983-1019
PROSITE-ProRule
EGF-like 27 1021-1057
PROSITE-ProRule
EGF-like 28 1059-1095
PROSITE-ProRule
EGF-like 29 1097-1143

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EGF-like 30 1145-1181
PROSITE-ProRule
EGF-like 31; calcium-binding 1183-1219
PROSITE-ProRule
EGF-like 32; calcium-binding 1221-1265
PROSITE-ProRule
EGF-like 33 1267-1305
PROSITE-ProRule
EGF-like 34 1307-1346
PROSITE-ProRule
EGF-like 35 1348-1384
PROSITE-ProRule
EGF-like 36 1387-1426
PROSITE-ProRule
View in

Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PLK1NOTCH1–phosphorylation
down-regulates activity		31597699SIGNOR-279096
CyclinC/CDK3NOTCH1–phosphorylation
down-regulates quantity by destabilization		25344755SIGNOR-273164
GSK3BNOTCH1–phosphorylation
up-regulates		12123574SIGNOR-90608
CDK3NOTCH1Ser2516FLTPSPEsPDQWSSSphosphorylation
down-regulates quantity by destabilization		25344755SIGNOR-273168
DYRK1ANOTCH1–phosphorylation
down-regulates		19383720SIGNOR-185494
MAP3K1NOTCH1–phosphorylation
down-regulates activity		27806347SIGNOR-279628
CyclinC/CDK19NOTCH1–phosphorylation
down-regulates quantity by destabilization		25344755SIGNOR-273162
CDK8NOTCH1Ser2516FLTPSPEsPDQWSSSphosphorylation
down-regulates quantity by destabilization		25344755SIGNOR-273177
CCNCNOTCH1–phosphorylation
down-regulates		15546612SIGNOR-130592
CDK3NOTCH1Thr2511VPEHPFLtPSPESPDphosphorylation
down-regulates quantity by destabilization		25344755SIGNOR-273167
CKM complexNOTCH1–phosphorylation
down-regulates quantity by destabilization		15546612SIGNOR-273150
CAMK4NOTCH1–phosphorylation
up-regulates quantity by stabilization		23103515SIGNOR-279596
CDK8NOTCH1–phosphorylation
down-regulates		15546612SIGNOR-130640
PLK1NOTCH1Ser1791REPLGEDsVGLKPLKphosphorylation
down-regulates quantity by destabilization		31597699SIGNOR-277491
GSK3ANOTCH1–phosphorylation
down-regulates		19214430SIGNOR-183969
CKM complexNOTCH1–phosphorylation
down-regulates quantity by destabilization		25344755SIGNOR-273159
PLK1NOTCH1Ser2439SFLSGEPsQADVQPLphosphorylation
down-regulates quantity by destabilization		31597699SIGNOR-277490
CDK8NOTCH1Thr2511VPEHPFLtPSPESPDphosphorylation
down-regulates quantity by destabilization		25344755SIGNOR-273178
NLKNOTCH1–phosphorylation
down-regulates		20118921SIGNOR-163697
CyclinC/CDK19NOTCH1–phosphorylation
down-regulates quantity by destabilization		25344755SIGNOR-273161
CDK19NOTCH1Ser2513EHPFLTPsPESPDQWphosphorylation
down-regulates quantity by destabilization		25344755SIGNOR-273136
CyclinC/CDK19NOTCH1–phosphorylation
down-regulates quantity by destabilization		25344755SIGNOR-273163
CDK8NOTCH1Ser2513EHPFLTPsPESPDQWphosphorylation
down-regulates quantity by destabilization		25344755SIGNOR-273176
CDK19NOTCH1Ser2516FLTPSPEsPDQWSSSphosphorylation
down-regulates quantity by destabilization		25344755SIGNOR-273135
CDK5NOTCH1–phosphorylation
up-regulates activity		33960694SIGNOR-279401
CKM complexNOTCH1–phosphorylation
down-regulates quantity by destabilization		25344755SIGNOR-273158
CDK3NOTCH1Ser2513EHPFLTPsPESPDQWphosphorylation
down-regulates quantity by destabilization		25344755SIGNOR-273169
PIM1NOTCH1–phosphorylation
up-regulates activity		27281612SIGNOR-279643
CKM complexNOTCH1–phosphorylation
down-regulates quantity by destabilization		25344755SIGNOR-273160
CyclinC/CDK3NOTCH1–phosphorylation
down-regulates quantity by destabilization		25344755SIGNOR-273165
DYRK2NOTCH1–phosphorylation
down-regulates quantity by destabilization		31605148SIGNOR-279035
CyclinC/CDK3NOTCH1–phosphorylation
down-regulates quantity by destabilization		25344755SIGNOR-273166
CDK19NOTCH1Thr2511VPEHPFLtPSPESPDphosphorylation
down-regulates quantity by destabilization		25344755SIGNOR-273137
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CDK3phosphorylation
up-regulates
→
NOTCH1
PSer2516		phosphorylation
down-regulates
⊣		NOTCH125344755SIGNOR-273168
CDK8phosphorylation
up-regulates
→
NOTCH1
PSer2516		phosphorylation
down-regulates
⊣		NOTCH125344755SIGNOR-273177
CDK3phosphorylation
up-regulates
→
NOTCH1
PThr2511		phosphorylation
down-regulates
⊣		NOTCH125344755SIGNOR-273167
PLK1phosphorylation
up-regulates
→
NOTCH1
PSer1791		phosphorylation
down-regulates
⊣		NOTCH131597699SIGNOR-277491
PLK1phosphorylation
up-regulates
→
NOTCH1
PSer2439		phosphorylation
down-regulates
⊣		NOTCH131597699SIGNOR-277490
CDK8phosphorylation
up-regulates
→
NOTCH1
PThr2511		phosphorylation
down-regulates
⊣		NOTCH125344755SIGNOR-273178
CDK19phosphorylation
up-regulates
→
NOTCH1
PSer2513		phosphorylation
down-regulates
⊣		NOTCH125344755SIGNOR-273136
CDK8phosphorylation
up-regulates
→
NOTCH1
PSer2513		phosphorylation
down-regulates
⊣		NOTCH125344755SIGNOR-273176
CDK19phosphorylation
up-regulates
→
NOTCH1
PSer2516		phosphorylation
down-regulates
⊣		NOTCH125344755SIGNOR-273135
CDK3phosphorylation
up-regulates
→
NOTCH1
PSer2513		phosphorylation
down-regulates
⊣		NOTCH125344755SIGNOR-273169
CDK19phosphorylation
up-regulates
→
NOTCH1
PThr2511		phosphorylation
down-regulates
⊣		NOTCH125344755SIGNOR-273137
Regulator Mechanism/Effect Target SIGNOR-ID
PLK1phosphorylation
→
down-regulates activity 		NOTCH1SIGNOR-279096
CyclinC/CDK3phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		NOTCH1SIGNOR-273164
GSK3Bphosphorylation
→
up-regulates 		NOTCH1SIGNOR-90608
CDK3phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		NOTCH1SIGNOR-273168
DYRK1Aphosphorylation
img/direct_inhibition.png
down-regulates 		NOTCH1SIGNOR-185494
MAP3K1phosphorylation
→
down-regulates activity 		NOTCH1SIGNOR-279628
CyclinC/CDK19phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		NOTCH1SIGNOR-273162
CDK8phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		NOTCH1SIGNOR-273177
CCNCphosphorylation
img/direct_inhibition.png
down-regulates 		NOTCH1SIGNOR-130592
CDK3phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		NOTCH1SIGNOR-273167
CKM complexphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		NOTCH1SIGNOR-273150
CAMK4phosphorylation
→
up-regulates quantity by stabilization 		NOTCH1SIGNOR-279596
CDK8phosphorylation
img/direct_inhibition.png
down-regulates 		NOTCH1SIGNOR-130640
PLK1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		NOTCH1SIGNOR-277491
GSK3Aphosphorylation
img/direct_inhibition.png
down-regulates 		NOTCH1SIGNOR-183969
CKM complexphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		NOTCH1SIGNOR-273159
PLK1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		NOTCH1SIGNOR-277490
CDK8phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		NOTCH1SIGNOR-273178
NLKphosphorylation
img/direct_inhibition.png
down-regulates 		NOTCH1SIGNOR-163697
CyclinC/CDK19phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		NOTCH1SIGNOR-273161
CDK19phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		NOTCH1SIGNOR-273136
CyclinC/CDK19phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		NOTCH1SIGNOR-273163
CDK8phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		NOTCH1SIGNOR-273176
CDK19phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		NOTCH1SIGNOR-273135
CDK5phosphorylation
→
up-regulates activity 		NOTCH1SIGNOR-279401
CKM complexphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		NOTCH1SIGNOR-273158
CDK3phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		NOTCH1SIGNOR-273169
PIM1phosphorylation
→
up-regulates activity 		NOTCH1SIGNOR-279643
CKM complexphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		NOTCH1SIGNOR-273160
CyclinC/CDK3phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		NOTCH1SIGNOR-273165
DYRK2phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		NOTCH1SIGNOR-279035
CyclinC/CDK3phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		NOTCH1SIGNOR-273166
CDK19phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		NOTCH1SIGNOR-273137