Entity Details

Name CDK8_Thr2511
ID P46531
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CDK3NOTCH1Thr2511VPEHPFLtPSPESPDphosphorylation
down-regulates quantity by destabilization		25344755SIGNOR-273167
CDK8NOTCH1Thr2511VPEHPFLtPSPESPDphosphorylation
down-regulates quantity by destabilization		25344755SIGNOR-273178
CDK19NOTCH1Thr2511VPEHPFLtPSPESPDphosphorylation
down-regulates quantity by destabilization		25344755SIGNOR-273137
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CDK3phosphorylation
up-regulates
→
NOTCH1
PThr2511		phosphorylation
down-regulates
⊣		NOTCH125344755SIGNOR-273167
CDK8phosphorylation
up-regulates
→
NOTCH1
PThr2511		phosphorylation
down-regulates
⊣		NOTCH125344755SIGNOR-273178
CDK19phosphorylation
up-regulates
→
NOTCH1
PThr2511		phosphorylation
down-regulates
⊣		NOTCH125344755SIGNOR-273137
Regulator Mechanism/Effect Target SIGNOR-ID
CDK3phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		NOTCH1SIGNOR-273167
CDK8phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		NOTCH1SIGNOR-273178
CDK19phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		NOTCH1SIGNOR-273137