| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | NOTCH1 | Ser1791 | REPLGEDsVGLKPLK | phosphorylation down-regulates quantity by destabilization | 31597699 | SIGNOR-277491 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | phosphorylation up-regulates → | NOTCH1 PSer1791 | phosphorylation down-regulates ⊣ | NOTCH1 | 31597699 | SIGNOR-277491 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PLK1 | phosphorylation![]() down-regulates quantity by destabilization | NOTCH1 | SIGNOR-277491 |