Entity Details

Name NOTCH1_Ser2516
ID P46531
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CDK19NOTCH1Ser2516FLTPSPEsPDQWSSSphosphorylation
down-regulates quantity by destabilization		25344755SIGNOR-273135
CDK3NOTCH1Ser2516FLTPSPEsPDQWSSSphosphorylation
down-regulates quantity by destabilization		25344755SIGNOR-273168
CDK8NOTCH1Ser2516FLTPSPEsPDQWSSSphosphorylation
down-regulates quantity by destabilization		25344755SIGNOR-273177
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CDK19phosphorylation
up-regulates
→
NOTCH1
PSer2516		phosphorylation
down-regulates
⊣		NOTCH125344755SIGNOR-273135
CDK3phosphorylation
up-regulates
→
NOTCH1
PSer2516		phosphorylation
down-regulates
⊣		NOTCH125344755SIGNOR-273168
CDK8phosphorylation
up-regulates
→
NOTCH1
PSer2516		phosphorylation
down-regulates
⊣		NOTCH125344755SIGNOR-273177
Regulator Mechanism/Effect Target SIGNOR-ID
CDK19phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		NOTCH1SIGNOR-273135
CDK3phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		NOTCH1SIGNOR-273168
CDK8phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		NOTCH1SIGNOR-273177