| Name | MAP2K3 |
| ID | P46734 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 64-325 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP2K3 | MAPK13 | Thr180 | RHADAEMtGYVVTRW | phosphorylation up-regulates activity | 10066767 | SIGNOR-273950 |
| MAP2K3 | MAPK13 | Tyr182 | ADAEMTGyVVTRWYR | phosphorylation up-regulates activity | 10066767 | SIGNOR-273949 |
| MAP2K3 | MAPK12 | – | phosphorylation up-regulates | 11062067 | SIGNOR-83718 | |
| MAP2K3 | MAPK14 | – | phosphorylation up-regulates activity | 7535770 | SIGNOR-236103 | |
| MAP2K3 | MAPK14 | – | phosphorylation up-regulates activity | 7839144 | SIGNOR-232156 | |
| MAP2K3 | MAPK14 | Thr180 | RHTDDEMtGYVATRW | phosphorylation up-regulates activity | 8622669 | SIGNOR-40349 |
| MAP2K3 | MAPK14 | Tyr182 | TDDEMTGyVATRWYR | phosphorylation up-regulates activity | 8622669 | SIGNOR-40353 |
| MAP2K3 | MAPK14 | – | phosphorylation up-regulates activity | 8622669 | SIGNOR-40356 | |
| MAP2K3 | DYRK1B | – | phosphorylation up-regulates | 11980910 | SIGNOR-86731 | |
| MAP2K3 | p38 | – | phosphorylation up-regulates activity | 7839144 | SIGNOR-260723 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP2K3 | phosphorylation up-regulates → | MAPK13 PThr180 | phosphorylation up-regulates → | MAPK13 | 10066767 | SIGNOR-273950 |
| MAP2K3 | phosphorylation up-regulates → | MAPK13 PTyr182 | phosphorylation up-regulates → | MAPK13 | 10066767 | SIGNOR-273949 |
| MAP2K3 | phosphorylation up-regulates → | MAPK14 PThr180 | phosphorylation up-regulates → | MAPK14 | 8622669 | SIGNOR-40349 |
| MAP2K3 | phosphorylation up-regulates → | MAPK14 PTyr182 | phosphorylation up-regulates → | MAPK14 | 8622669 | SIGNOR-40353 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAP2K3 | phosphorylation → up-regulates activity | MAPK13 | SIGNOR-273950 |
| MAP2K3 | phosphorylation → up-regulates activity | MAPK13 | SIGNOR-273949 |
| MAP2K3 | phosphorylation → up-regulates | MAPK12 | SIGNOR-83718 |
| MAP2K3 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-236103 |
| MAP2K3 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-232156 |
| MAP2K3 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-40349 |
| MAP2K3 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-40353 |
| MAP2K3 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-40356 |
| MAP2K3 | phosphorylation → up-regulates | DYRK1B | SIGNOR-86731 |
| MAP2K3 | phosphorylation → up-regulates activity | p38 | SIGNOR-260723 |