Entity Details

Name YAP1
ID P46937
Role substrate
Enzymatic Domains
WW 1 171-204
PROSITE-ProRule
WW 2 230-263
PROSITE-ProRule
View in

Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
STK11YAP1phosphorylation
down-regulates activity
23027127SIGNOR-280139
CSNK1DYAP1Ser400 SRDESTDsGLSMSSYphosphorylation
down-regulates
23431053SIGNOR-201143
NEK2YAP1Thr143 AVSPGTLtPTGVVSGphosphorylation
up-regulates quantity by stabilization
35705994SIGNOR-276586
LATS2YAP1Ser127 PQHVRAHsSPASLQLphosphorylation
down-regulates
22658639SIGNOR-197655
IKBKEYAP1Ser419 TPDDFLNsVDEMDTGphosphorylation
down-regulates quantity by destabilization
28481329SIGNOR-277355
CSNK1DYAP1Ser403ESTDSGLsMSSYSVPphosphorylation
down-regulates
24715453SIGNOR-230743
YES1YAP1Tyr407SGLSMSSySVPRTPDphosphorylation
up-regulates activity
23245941SIGNOR-278248
LATS1YAP1Ser127 PQHVRAHsSPASLQLphosphorylation
down-regulates
22658639SIGNOR-197647
AKT1YAP1Ser127 PQHVRAHsSPASLQLphosphorylation
down-regulates
12535517SIGNOR-252593
PRKCZYAP1Ser109 KSHSRQAsTDAGTAGphosphorylation
down-regulates quantity by destabilization
25660024SIGNOR-276876
CyclinB/CDK1YAP1Ser367 GTQNPVSsPGMSQELphosphorylation
up-regulates activity
26933062SIGNOR-276590
JNKYAP1Ser138 SLQLGAVsPGTLTPTphosphorylation
up-regulates activity
21364637SIGNOR-277642
CDK1YAP1Thr143 AVSPGTLtPTGVVSGphosphorylation
up-regulates activity
26933062SIGNOR-276588
STK38YAP1Ser109 KSHSRQAsTDAGTAGphosphorylation
down-regulates activity
25601544SIGNOR-259856
CDK8YAP1Ser289 PPPLAPQsPQGGVMGphosphorylation
up-regulates activity
29967145SIGNOR-277650
CDK8YAP1Thr119 AGTAGALtPQHVRAHphosphorylation
up-regulates activity
29967145SIGNOR-277648
AKTYAP1Ser127 PQHVRAHsSPASLQLphosphorylation
down-regulates
12535517SIGNOR-97485
LATS1/2YAP1Ser127 PQHVRAHsSPASLQLphosphorylation
down-regulates activity
22658639SIGNOR-256188
YES1YAP1Tyr407SGLSMSSySVPRTPDphosphorylation
up-regulates activity
35041461SIGNOR-277653
PPP1CAYAP1Ser127 PQHVRAHsSPASLQLdephosphorylation
up-regulates activity
21909427SIGNOR-276999
LATS1/2YAP1Ser397 TYHSRDEsTDSGLSMphosphorylation
down-regulates quantity by destabilization
20048001SIGNOR-277636
FRKYAP1Tyr407SGLSMSSySVPRTPDphosphorylation
down-regulates quantity by destabilization
35723276SIGNOR-275456
JNKYAP1Ser367 GTQNPVSsPGMSQELphosphorylation
up-regulates activity
21364637SIGNOR-277644
YES1YAP1Tyr391PFLNSGTyHSRDESTphosphorylation
up-regulates activity
35041461SIGNOR-277652
JNKYAP1Thr154VVSGPAAtPTAQHLRphosphorylation
up-regulates activity
21364637SIGNOR-277643
STK38YAP1Ser127 PQHVRAHsSPASLQLphosphorylation
down-regulates activity
25601544SIGNOR-259855
CDK1YAP1Thr119 AGTAGALtPQHVRAHphosphorylation
up-regulates activity
24101154SIGNOR-279361
LATS2YAP1Ser397 TYHSRDEsTDSGLSMphosphorylation
down-regulates quantity by destabilization
20048001SIGNOR-218038
LATS2YAP1Ser127 PQHVRAHsSPASLQLphosphorylation
down-regulates
22863277SIGNOR-198514
MAP3K7YAP1Ser127 PQHVRAHsSPASLQLphosphorylation
down-regulates activity
30385786SIGNOR-278956
STK25YAP1phosphorylation
up-regulates activity
30948712SIGNOR-278993
STK26YAP1Thr83KTANVPQtVPMRLRKphosphorylation
down-regulates activity
32271880SIGNOR-278994
ULK1YAP1Ser227VQQNMMNsASGPLPDphosphorylation
up-regulates quantity by stabilization
34345207SIGNOR-277570
AMPKYAP1Ser94 RLRKLPDsFFKPPEPphosphorylation
down-regulates activity
25751140SIGNOR-277638
FRKYAP1Tyr444QQNRFPDyLEAIPGTphosphorylation
down-regulates quantity by destabilization
35723276SIGNOR-275457
JNKYAP1Thr119 AGTAGALtPQHVRAHphosphorylation
up-regulates activity
21364637SIGNOR-277641
CDK1YAP1Ser367 GTQNPVSsPGMSQELphosphorylation
up-regulates activity
24101154SIGNOR-279363
CDK8YAP1Ser128 QHVRAHSsPASLQLGphosphorylation
up-regulates activity
29967145SIGNOR-277649
ABL1YAP1Tyr407SGLSMSSySVPRTPDphosphorylation
up-regulates
18280240SIGNOR-160860
PPM1AYAP1Ser127 PQHVRAHsSPASLQLdephosphorylation
up-regulates activity
33630828SIGNOR-276984
CSNK1EYAP1Ser400 SRDESTDsGLSMSSYphosphorylation
down-regulates
23431053SIGNOR-201165
NLKYAP1Ser128 QHVRAHSsPASLQLGphosphorylation
up-regulates activity
27979971SIGNOR-273909
CSNK1EYAP1Ser400 SRDESTDsGLSMSSYphosphorylation
down-regulates
24715453SIGNOR-230728
CSNK1DYAP1Ser403ESTDSGLsMSSYSVPphosphorylation
down-regulates
23431053SIGNOR-201154
CDK8YAP1Ser367 GTQNPVSsPGMSQELphosphorylation
up-regulates activity
29967145SIGNOR-277651
PTK2YAP1phosphorylation
up-regulates activity
33498611SIGNOR-280099
CSNK1DYAP1Ser400 SRDESTDsGLSMSSYphosphorylation
down-regulates
24715453SIGNOR-230738
CDK1YAP1Ser138 SLQLGAVsPGTLTPTphosphorylation
up-regulates activity
26933062SIGNOR-276589
FRKYAP1Tyr391PFLNSGTyHSRDESTphosphorylation
down-regulates quantity by destabilization
35723276SIGNOR-275455
LATS1YAP1Ser397 TYHSRDEsTDSGLSMphosphorylation
down-regulates quantity by destabilization
20048001SIGNOR-218034
CDK1YAP1Ser367 GTQNPVSsPGMSQELphosphorylation
up-regulates activity
26933062SIGNOR-276587
PRKCZYAP1Thr110 SHSRQAStDAGTAGAphosphorylation
down-regulates quantity by destabilization
25660024SIGNOR-276877
CyclinB/CDK1YAP1Ser138 SLQLGAVsPGTLTPTphosphorylation
up-regulates activity
26933062SIGNOR-276592
CSNK1EYAP1Ser403ESTDSGLsMSSYSVPphosphorylation
down-regulates
24715453SIGNOR-230733
CyclinB/CDK1YAP1Thr143 AVSPGTLtPTGVVSGphosphorylation
up-regulates activity
26933062SIGNOR-276591
mTORC2YAP1Ser436INQSTLPsQQNRFPDphosphorylation
up-regulates activity
34343821SIGNOR-277569
JNKYAP1Ser400 SRDESTDsGLSMSSYphosphorylation
up-regulates activity
21364637SIGNOR-277645
CDK1YAP1Ser289 PPPLAPQsPQGGVMGphosphorylation
up-regulates activity
24101154SIGNOR-279362
CSNK1EYAP1Ser403ESTDSGLsMSSYSVPphosphorylation
down-regulates
23431053SIGNOR-201170
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CSNK1Dphosphorylation
up-regulates
YAP1
PSer400
phosphorylation
down-regulates
YAP123431053SIGNOR-201143
NEK2phosphorylation
up-regulates
YAP1
PThr143
phosphorylation
up-regulates
YAP135705994SIGNOR-276586
LATS2phosphorylation
up-regulates
YAP1
PSer127
phosphorylation
down-regulates
YAP122658639SIGNOR-197655
IKBKEphosphorylation
up-regulates
YAP1
PSer419
phosphorylation
down-regulates
YAP128481329SIGNOR-277355
CSNK1Dphosphorylation
up-regulates
YAP1
PSer403
phosphorylation
down-regulates
YAP124715453SIGNOR-230743
YES1phosphorylation
up-regulates
YAP1
PTyr407
phosphorylation
up-regulates
YAP123245941SIGNOR-278248
LATS1phosphorylation
up-regulates
YAP1
PSer127
phosphorylation
down-regulates
YAP122658639SIGNOR-197647
AKT1phosphorylation
up-regulates
YAP1
PSer127
phosphorylation
down-regulates
YAP112535517SIGNOR-252593
PRKCZphosphorylation
up-regulates
YAP1
PSer109
phosphorylation
down-regulates
YAP125660024SIGNOR-276876
CyclinB/CDK1phosphorylation
up-regulates
YAP1
PSer367
phosphorylation
up-regulates
YAP126933062SIGNOR-276590
JNKphosphorylation
up-regulates
YAP1
PSer138
phosphorylation
up-regulates
YAP121364637SIGNOR-277642
CDK1phosphorylation
up-regulates
YAP1
PThr143
phosphorylation
up-regulates
YAP126933062SIGNOR-276588
STK38phosphorylation
up-regulates
YAP1
PSer109
phosphorylation
down-regulates
YAP125601544SIGNOR-259856
CDK8phosphorylation
up-regulates
YAP1
PSer289
phosphorylation
up-regulates
YAP129967145SIGNOR-277650
CDK8phosphorylation
up-regulates
YAP1
PThr119
phosphorylation
up-regulates
YAP129967145SIGNOR-277648
AKTphosphorylation
up-regulates
YAP1
PSer127
phosphorylation
down-regulates
YAP112535517SIGNOR-97485
LATS1/2phosphorylation
up-regulates
YAP1
PSer127
phosphorylation
down-regulates
YAP122658639SIGNOR-256188
YES1phosphorylation
up-regulates
YAP1
PTyr407
phosphorylation
up-regulates
YAP135041461SIGNOR-277653
PPP1CAdephosphorylation
down-regulates
YAP1
PSer127
dephosphorylation
down-regulates
YAP121909427SIGNOR-276999
LATS1/2phosphorylation
up-regulates
YAP1
PSer397
phosphorylation
down-regulates
YAP120048001SIGNOR-277636
FRKphosphorylation
up-regulates
YAP1
PTyr407
phosphorylation
down-regulates
YAP135723276SIGNOR-275456
JNKphosphorylation
up-regulates
YAP1
PSer367
phosphorylation
up-regulates
YAP121364637SIGNOR-277644
YES1phosphorylation
up-regulates
YAP1
PTyr391
phosphorylation
up-regulates
YAP135041461SIGNOR-277652
JNKphosphorylation
up-regulates
YAP1
PThr154
phosphorylation
up-regulates
YAP121364637SIGNOR-277643
STK38phosphorylation
up-regulates
YAP1
PSer127
phosphorylation
down-regulates
YAP125601544SIGNOR-259855
CDK1phosphorylation
up-regulates
YAP1
PThr119
phosphorylation
up-regulates
YAP124101154SIGNOR-279361
LATS2phosphorylation
up-regulates
YAP1
PSer397
phosphorylation
down-regulates
YAP120048001SIGNOR-218038
LATS2phosphorylation
up-regulates
YAP1
PSer127
phosphorylation
down-regulates
YAP122863277SIGNOR-198514
MAP3K7phosphorylation
up-regulates
YAP1
PSer127
phosphorylation
down-regulates
YAP130385786SIGNOR-278956
STK26phosphorylation
up-regulates
YAP1
PThr83
phosphorylation
down-regulates
YAP132271880SIGNOR-278994
ULK1phosphorylation
up-regulates
YAP1
PSer227
phosphorylation
up-regulates
YAP134345207SIGNOR-277570
AMPKphosphorylation
up-regulates
YAP1
PSer94
phosphorylation
down-regulates
YAP125751140SIGNOR-277638
FRKphosphorylation
up-regulates
YAP1
PTyr444
phosphorylation
down-regulates
YAP135723276SIGNOR-275457
JNKphosphorylation
up-regulates
YAP1
PThr119
phosphorylation
up-regulates
YAP121364637SIGNOR-277641
CDK1phosphorylation
up-regulates
YAP1
PSer367
phosphorylation
up-regulates
YAP124101154SIGNOR-279363
CDK8phosphorylation
up-regulates
YAP1
PSer128
phosphorylation
up-regulates
YAP129967145SIGNOR-277649
ABL1phosphorylation
up-regulates
YAP1
PTyr407
phosphorylation
up-regulates
YAP118280240SIGNOR-160860
PPM1Adephosphorylation
down-regulates
YAP1
PSer127
dephosphorylation
down-regulates
YAP133630828SIGNOR-276984
CSNK1Ephosphorylation
up-regulates
YAP1
PSer400
phosphorylation
down-regulates
YAP123431053SIGNOR-201165
NLKphosphorylation
up-regulates
YAP1
PSer128
phosphorylation
up-regulates
YAP127979971SIGNOR-273909
CSNK1Ephosphorylation
up-regulates
YAP1
PSer400
phosphorylation
down-regulates
YAP124715453SIGNOR-230728
CSNK1Dphosphorylation
up-regulates
YAP1
PSer403
phosphorylation
down-regulates
YAP123431053SIGNOR-201154
CDK8phosphorylation
up-regulates
YAP1
PSer367
phosphorylation
up-regulates
YAP129967145SIGNOR-277651
CSNK1Dphosphorylation
up-regulates
YAP1
PSer400
phosphorylation
down-regulates
YAP124715453SIGNOR-230738
CDK1phosphorylation
up-regulates
YAP1
PSer138
phosphorylation
up-regulates
YAP126933062SIGNOR-276589
FRKphosphorylation
up-regulates
YAP1
PTyr391
phosphorylation
down-regulates
YAP135723276SIGNOR-275455
LATS1phosphorylation
up-regulates
YAP1
PSer397
phosphorylation
down-regulates
YAP120048001SIGNOR-218034
CDK1phosphorylation
up-regulates
YAP1
PSer367
phosphorylation
up-regulates
YAP126933062SIGNOR-276587
PRKCZphosphorylation
up-regulates
YAP1
PThr110
phosphorylation
down-regulates
YAP125660024SIGNOR-276877
CyclinB/CDK1phosphorylation
up-regulates
YAP1
PSer138
phosphorylation
up-regulates
YAP126933062SIGNOR-276592
CSNK1Ephosphorylation
up-regulates
YAP1
PSer403
phosphorylation
down-regulates
YAP124715453SIGNOR-230733
CyclinB/CDK1phosphorylation
up-regulates
YAP1
PThr143
phosphorylation
up-regulates
YAP126933062SIGNOR-276591
mTORC2phosphorylation
up-regulates
YAP1
PSer436
phosphorylation
up-regulates
YAP134343821SIGNOR-277569
JNKphosphorylation
up-regulates
YAP1
PSer400
phosphorylation
up-regulates
YAP121364637SIGNOR-277645
CDK1phosphorylation
up-regulates
YAP1
PSer289
phosphorylation
up-regulates
YAP124101154SIGNOR-279362
CSNK1Ephosphorylation
up-regulates
YAP1
PSer403
phosphorylation
down-regulates
YAP123431053SIGNOR-201170
Regulator Mechanism/Effect Target SIGNOR-ID
STK11phosphorylation

down-regulates activity
YAP1SIGNOR-280139
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates
YAP1SIGNOR-201143
NEK2phosphorylation

up-regulates quantity by stabilization
YAP1SIGNOR-276586
LATS2phosphorylation
img/direct_inhibition.png
down-regulates
YAP1SIGNOR-197655
IKBKEphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
YAP1SIGNOR-277355
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates
YAP1SIGNOR-230743
YES1phosphorylation

up-regulates activity
YAP1SIGNOR-278248
LATS1phosphorylation
img/direct_inhibition.png
down-regulates
YAP1SIGNOR-197647
AKT1phosphorylation
img/direct_inhibition.png
down-regulates
YAP1SIGNOR-252593
PRKCZphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
YAP1SIGNOR-276876
CyclinB/CDK1phosphorylation

up-regulates activity
YAP1SIGNOR-276590
JNKphosphorylation

up-regulates activity
YAP1SIGNOR-277642
CDK1phosphorylation

up-regulates activity
YAP1SIGNOR-276588
STK38phosphorylation

down-regulates activity
YAP1SIGNOR-259856
CDK8phosphorylation

up-regulates activity
YAP1SIGNOR-277650
CDK8phosphorylation

up-regulates activity
YAP1SIGNOR-277648
AKTphosphorylation
img/direct_inhibition.png
down-regulates
YAP1SIGNOR-97485
LATS1/2phosphorylation

down-regulates activity
YAP1SIGNOR-256188
YES1phosphorylation

up-regulates activity
YAP1SIGNOR-277653
PPP1CAdephosphorylation

up-regulates activity
YAP1SIGNOR-276999
LATS1/2phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
YAP1SIGNOR-277636
FRKphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
YAP1SIGNOR-275456
JNKphosphorylation

up-regulates activity
YAP1SIGNOR-277644
YES1phosphorylation

up-regulates activity
YAP1SIGNOR-277652
JNKphosphorylation

up-regulates activity
YAP1SIGNOR-277643
STK38phosphorylation

down-regulates activity
YAP1SIGNOR-259855
CDK1phosphorylation

up-regulates activity
YAP1SIGNOR-279361
LATS2phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
YAP1SIGNOR-218038
LATS2phosphorylation
img/direct_inhibition.png
down-regulates
YAP1SIGNOR-198514
MAP3K7phosphorylation

down-regulates activity
YAP1SIGNOR-278956
STK25phosphorylation

up-regulates activity
YAP1SIGNOR-278993
STK26phosphorylation

down-regulates activity
YAP1SIGNOR-278994
ULK1phosphorylation

up-regulates quantity by stabilization
YAP1SIGNOR-277570
AMPKphosphorylation

down-regulates activity
YAP1SIGNOR-277638
FRKphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
YAP1SIGNOR-275457
JNKphosphorylation

up-regulates activity
YAP1SIGNOR-277641
CDK1phosphorylation

up-regulates activity
YAP1SIGNOR-279363
CDK8phosphorylation

up-regulates activity
YAP1SIGNOR-277649
ABL1phosphorylation

up-regulates
YAP1SIGNOR-160860
PPM1Adephosphorylation

up-regulates activity
YAP1SIGNOR-276984
CSNK1Ephosphorylation
img/direct_inhibition.png
down-regulates
YAP1SIGNOR-201165
NLKphosphorylation

up-regulates activity
YAP1SIGNOR-273909
CSNK1Ephosphorylation
img/direct_inhibition.png
down-regulates
YAP1SIGNOR-230728
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates
YAP1SIGNOR-201154
CDK8phosphorylation

up-regulates activity
YAP1SIGNOR-277651
PTK2phosphorylation

up-regulates activity
YAP1SIGNOR-280099
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates
YAP1SIGNOR-230738
CDK1phosphorylation

up-regulates activity
YAP1SIGNOR-276589
FRKphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
YAP1SIGNOR-275455
LATS1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
YAP1SIGNOR-218034
CDK1phosphorylation

up-regulates activity
YAP1SIGNOR-276587
PRKCZphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
YAP1SIGNOR-276877
CyclinB/CDK1phosphorylation

up-regulates activity
YAP1SIGNOR-276592
CSNK1Ephosphorylation
img/direct_inhibition.png
down-regulates
YAP1SIGNOR-230733
CyclinB/CDK1phosphorylation

up-regulates activity
YAP1SIGNOR-276591
mTORC2phosphorylation

up-regulates activity
YAP1SIGNOR-277569
JNKphosphorylation

up-regulates activity
YAP1SIGNOR-277645
CDK1phosphorylation

up-regulates activity
YAP1SIGNOR-279362
CSNK1Ephosphorylation
img/direct_inhibition.png
down-regulates
YAP1SIGNOR-201170