| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LATS2 | YAP1 | Ser127 | PQHVRAHsSPASLQL | phosphorylation down-regulates | 22658639 | SIGNOR-197655 |
| LATS1 | YAP1 | Ser127 | PQHVRAHsSPASLQL | phosphorylation down-regulates | 22658639 | SIGNOR-197647 |
| AKT1 | YAP1 | Ser127 | PQHVRAHsSPASLQL | phosphorylation down-regulates | 12535517 | SIGNOR-252593 |
| AKT | YAP1 | Ser127 | PQHVRAHsSPASLQL | phosphorylation down-regulates | 12535517 | SIGNOR-97485 |
| LATS1/2 | YAP1 | Ser127 | PQHVRAHsSPASLQL | phosphorylation down-regulates activity | 22658639 | SIGNOR-256188 |
| PPP1CA | YAP1 | Ser127 | PQHVRAHsSPASLQL | dephosphorylation up-regulates activity | 21909427 | SIGNOR-276999 |
| STK38 | YAP1 | Ser127 | PQHVRAHsSPASLQL | phosphorylation down-regulates activity | 25601544 | SIGNOR-259855 |
| LATS2 | YAP1 | Ser127 | PQHVRAHsSPASLQL | phosphorylation down-regulates | 22863277 | SIGNOR-198514 |
| MAP3K7 | YAP1 | Ser127 | PQHVRAHsSPASLQL | phosphorylation down-regulates activity | 30385786 | SIGNOR-278956 |
| PPM1A | YAP1 | Ser127 | PQHVRAHsSPASLQL | dephosphorylation up-regulates activity | 33630828 | SIGNOR-276984 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LATS2 | phosphorylation up-regulates → | YAP1 PSer127 | phosphorylation down-regulates ⊣ | YAP1 | 22658639 | SIGNOR-197655 |
| LATS1 | phosphorylation up-regulates → | YAP1 PSer127 | phosphorylation down-regulates ⊣ | YAP1 | 22658639 | SIGNOR-197647 |
| AKT1 | phosphorylation up-regulates → | YAP1 PSer127 | phosphorylation down-regulates ⊣ | YAP1 | 12535517 | SIGNOR-252593 |
| AKT | phosphorylation up-regulates → | YAP1 PSer127 | phosphorylation down-regulates ⊣ | YAP1 | 12535517 | SIGNOR-97485 |
| LATS1/2 | phosphorylation up-regulates → | YAP1 PSer127 | phosphorylation down-regulates ⊣ | YAP1 | 22658639 | SIGNOR-256188 |
| PPP1CA | dephosphorylation down-regulates ⊣ | YAP1 PSer127 | dephosphorylation down-regulates ⊣ | YAP1 | 21909427 | SIGNOR-276999 |
| STK38 | phosphorylation up-regulates → | YAP1 PSer127 | phosphorylation down-regulates ⊣ | YAP1 | 25601544 | SIGNOR-259855 |
| LATS2 | phosphorylation up-regulates → | YAP1 PSer127 | phosphorylation down-regulates ⊣ | YAP1 | 22863277 | SIGNOR-198514 |
| MAP3K7 | phosphorylation up-regulates → | YAP1 PSer127 | phosphorylation down-regulates ⊣ | YAP1 | 30385786 | SIGNOR-278956 |
| PPM1A | dephosphorylation down-regulates ⊣ | YAP1 PSer127 | dephosphorylation down-regulates ⊣ | YAP1 | 33630828 | SIGNOR-276984 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| LATS2 | phosphorylation down-regulates | YAP1 | SIGNOR-197655 |
| LATS1 | phosphorylation down-regulates | YAP1 | SIGNOR-197647 |
| AKT1 | phosphorylation down-regulates | YAP1 | SIGNOR-252593 |
| AKT | phosphorylation down-regulates | YAP1 | SIGNOR-97485 |
| LATS1/2 | phosphorylation → down-regulates activity | YAP1 | SIGNOR-256188 |
| PPP1CA | dephosphorylation → up-regulates activity | YAP1 | SIGNOR-276999 |
| STK38 | phosphorylation → down-regulates activity | YAP1 | SIGNOR-259855 |
| LATS2 | phosphorylation down-regulates | YAP1 | SIGNOR-198514 |
| MAP3K7 | phosphorylation → down-regulates activity | YAP1 | SIGNOR-278956 |
| PPM1A | dephosphorylation → up-regulates activity | YAP1 | SIGNOR-276984 |
