| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JNK | YAP1 | Ser400 | SRDESTDsGLSMSSY | phosphorylation up-regulates activity | 21364637 | SIGNOR-277645 |
| CSNK1D | YAP1 | Ser400 | SRDESTDsGLSMSSY | phosphorylation down-regulates | 23431053 | SIGNOR-201143 |
| CSNK1E | YAP1 | Ser400 | SRDESTDsGLSMSSY | phosphorylation down-regulates | 23431053 | SIGNOR-201165 |
| CSNK1E | YAP1 | Ser400 | SRDESTDsGLSMSSY | phosphorylation down-regulates | 24715453 | SIGNOR-230728 |
| CSNK1D | YAP1 | Ser400 | SRDESTDsGLSMSSY | phosphorylation down-regulates | 24715453 | SIGNOR-230738 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JNK | phosphorylation up-regulates → | YAP1 PSer400 | phosphorylation up-regulates → | YAP1 | 21364637 | SIGNOR-277645 |
| CSNK1D | phosphorylation up-regulates → | YAP1 PSer400 | phosphorylation down-regulates ⊣ | YAP1 | 23431053 | SIGNOR-201143 |
| CSNK1E | phosphorylation up-regulates → | YAP1 PSer400 | phosphorylation down-regulates ⊣ | YAP1 | 23431053 | SIGNOR-201165 |
| CSNK1E | phosphorylation up-regulates → | YAP1 PSer400 | phosphorylation down-regulates ⊣ | YAP1 | 24715453 | SIGNOR-230728 |
| CSNK1D | phosphorylation up-regulates → | YAP1 PSer400 | phosphorylation down-regulates ⊣ | YAP1 | 24715453 | SIGNOR-230738 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| JNK | phosphorylation → up-regulates activity | YAP1 | SIGNOR-277645 |
| CSNK1D | phosphorylation down-regulates | YAP1 | SIGNOR-201143 |
| CSNK1E | phosphorylation down-regulates | YAP1 | SIGNOR-201165 |
| CSNK1E | phosphorylation down-regulates | YAP1 | SIGNOR-230728 |
| CSNK1D | phosphorylation down-regulates | YAP1 | SIGNOR-230738 |
