| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LATS1/2 | YAP1 | Ser397 | TYHSRDEsTDSGLSM | phosphorylation down-regulates quantity by destabilization | 20048001 | SIGNOR-277636 |
| LATS2 | YAP1 | Ser397 | TYHSRDEsTDSGLSM | phosphorylation down-regulates quantity by destabilization | 20048001 | SIGNOR-218038 |
| LATS1 | YAP1 | Ser397 | TYHSRDEsTDSGLSM | phosphorylation down-regulates quantity by destabilization | 20048001 | SIGNOR-218034 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LATS1/2 | phosphorylation up-regulates → | YAP1 PSer397 | phosphorylation down-regulates ⊣ | YAP1 | 20048001 | SIGNOR-277636 |
| LATS2 | phosphorylation up-regulates → | YAP1 PSer397 | phosphorylation down-regulates ⊣ | YAP1 | 20048001 | SIGNOR-218038 |
| LATS1 | phosphorylation up-regulates → | YAP1 PSer397 | phosphorylation down-regulates ⊣ | YAP1 | 20048001 | SIGNOR-218034 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| LATS1/2 | phosphorylation![]() down-regulates quantity by destabilization | YAP1 | SIGNOR-277636 |
| LATS2 | phosphorylation![]() down-regulates quantity by destabilization | YAP1 | SIGNOR-218038 |
| LATS1 | phosphorylation![]() down-regulates quantity by destabilization | YAP1 | SIGNOR-218034 |