| Name | IQGAP1 |
| ID | P46940 |
| Role | substrate |
| Enzymatic Domains |
Calponin-homology (CH) 44-159 PROSITE-ProRule
WW 679-712 PROSITE-ProRule
IQ 1 745-774 PROSITE-ProRule
IQ 2 775-804 PROSITE-ProRule
IQ 3 805-834 PROSITE-ProRule
IQ 4 835-864 PROSITE-ProRule
Ras-GAP 1020-1269 PROSITE-ProRule |
View in  |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | IQGAP1 | Ser1443 | DKMKKSKsVKEDSNL | phosphorylation up-regulates | 21349850 | SIGNOR-172235 |
| MET | IQGAP1 | Tyr1510 | LVKLQQTyAALNSKA | phosphorylation up-regulates activity | 33087447 | SIGNOR-277532 |
| SRC | IQGAP1 | Tyr1510 | LVKLQQTyAALNSKA | phosphorylation up-regulates activity | 33087447 | SIGNOR-277533 |
| PRKCA | IQGAP1 | Ser1443 | DKMKKSKsVKEDSNL | phosphorylation up-regulates | 15695813 | SIGNOR-133861 |
| PRKCE | IQGAP1 | Ser1443 | DKMKKSKsVKEDSNL | phosphorylation up-regulates | 15355962 | SIGNOR-128718 |
| PRKCA | IQGAP1 | Ser1443 | DKMKKSKsVKEDSNL | phosphorylation up-regulates | 15355962 | SIGNOR-128714 |
| PRKCE | IQGAP1 | Ser1443 | DKMKKSKsVKEDSNL | phosphorylation up-regulates | 21349850 | SIGNOR-172239 |
| MAP4K3 | IQGAP1 | Ser480 | NTVWKQLsSSVTGLT | phosphorylation up-regulates activity | 31431460 | SIGNOR-277479 |
| PRKCE | IQGAP1 | Ser1443 | DKMKKSKsVKEDSNL | phosphorylation up-regulates | 15695813 | SIGNOR-133865 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | phosphorylation up-regulates → | IQGAP1 PSer1443 | phosphorylation up-regulates → | IQGAP1 | 21349850 | SIGNOR-172235 |
| MET | phosphorylation up-regulates → | IQGAP1 PTyr1510 | phosphorylation up-regulates → | IQGAP1 | 33087447 | SIGNOR-277532 |
| SRC | phosphorylation up-regulates → | IQGAP1 PTyr1510 | phosphorylation up-regulates → | IQGAP1 | 33087447 | SIGNOR-277533 |
| PRKCA | phosphorylation up-regulates → | IQGAP1 PSer1443 | phosphorylation up-regulates → | IQGAP1 | 15695813 | SIGNOR-133861 |
| PRKCE | phosphorylation up-regulates → | IQGAP1 PSer1443 | phosphorylation up-regulates → | IQGAP1 | 15355962 | SIGNOR-128718 |
| PRKCA | phosphorylation up-regulates → | IQGAP1 PSer1443 | phosphorylation up-regulates → | IQGAP1 | 15355962 | SIGNOR-128714 |
| PRKCE | phosphorylation up-regulates → | IQGAP1 PSer1443 | phosphorylation up-regulates → | IQGAP1 | 21349850 | SIGNOR-172239 |
| MAP4K3 | phosphorylation up-regulates → | IQGAP1 PSer480 | phosphorylation up-regulates → | IQGAP1 | 31431460 | SIGNOR-277479 |
| PRKCE | phosphorylation up-regulates → | IQGAP1 PSer1443 | phosphorylation up-regulates → | IQGAP1 | 15695813 | SIGNOR-133865 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCA | phosphorylation → up-regulates | IQGAP1 | SIGNOR-172235 |
| MET | phosphorylation → up-regulates activity | IQGAP1 | SIGNOR-277532 |
| SRC | phosphorylation → up-regulates activity | IQGAP1 | SIGNOR-277533 |
| PRKCA | phosphorylation → up-regulates | IQGAP1 | SIGNOR-133861 |
| PRKCE | phosphorylation → up-regulates | IQGAP1 | SIGNOR-128718 |
| PRKCA | phosphorylation → up-regulates | IQGAP1 | SIGNOR-128714 |
| PRKCE | phosphorylation → up-regulates | IQGAP1 | SIGNOR-172239 |
| MAP4K3 | phosphorylation → up-regulates activity | IQGAP1 | SIGNOR-277479 |
| PRKCE | phosphorylation → up-regulates | IQGAP1 | SIGNOR-133865 |