| Name | PLA2G4A |
| ID | P47712 |
| Role | substrate |
| Enzymatic Domains |
C2 6-122 PROSITE-ProRule
PLA2c 140-740 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | PLA2G4A | Ser505 | LNTSYPLsPLSDFAT | phosphorylation up-regulates | 8381049 | SIGNOR-38434 |
| MAPK14 | PLA2G4A | Ser505 | LNTSYPLsPLSDFAT | phosphorylation up-regulates activity | 8910365 | SIGNOR-44673 |
| ERK1/2 | PLA2G4A | – | phosphorylation up-regulates | 8381049 | SIGNOR-270192 | |
| MKNK1 | PLA2G4A | Ser727 | RQNPSRCsVSLSNVE | phosphorylation up-regulates activity | 10978317 | SIGNOR-226633 |
| PRKCZ | PLA2G4A | Thr376 | GSKFFMGtVVKKYEE | phosphorylation up-regulates activity | 32559461 | SIGNOR-277518 |
| RPS6KA5 | PLA2G4A | Ser727 | RQNPSRCsVSLSNVE | phosphorylation up-regulates activity | 10978317 | SIGNOR-249051 |
| PRKCA | PLA2G4A | – | phosphorylation up-regulates | 16963226 | SIGNOR-149406 | |
| MAPK1 | PLA2G4A | Ser505 | LNTSYPLsPLSDFAT | phosphorylation unknown | 9468497 | SIGNOR-55706 |
| Gbeta | PLA2G4A | – | phosphorylation up-regulates | 8381049 | SIGNOR-270096 | |
| MAPKAPK5 | PLA2G4A | Ser727 | RQNPSRCsVSLSNVE | phosphorylation up-regulates activity | 10978317 | SIGNOR-250162 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | phosphorylation up-regulates → | PLA2G4A PSer505 | phosphorylation up-regulates → | PLA2G4A | 8381049 | SIGNOR-38434 |
| MAPK14 | phosphorylation up-regulates → | PLA2G4A PSer505 | phosphorylation up-regulates → | PLA2G4A | 8910365 | SIGNOR-44673 |
| MKNK1 | phosphorylation up-regulates → | PLA2G4A PSer727 | phosphorylation up-regulates → | PLA2G4A | 10978317 | SIGNOR-226633 |
| PRKCZ | phosphorylation up-regulates → | PLA2G4A PThr376 | phosphorylation up-regulates → | PLA2G4A | 32559461 | SIGNOR-277518 |
| RPS6KA5 | phosphorylation up-regulates → | PLA2G4A PSer727 | phosphorylation up-regulates → | PLA2G4A | 10978317 | SIGNOR-249051 |
| MAPK1 | phosphorylation up-regulates → | PLA2G4A PSer505 | phosphorylation down-regulates ⊣ | PLA2G4A | 9468497 | SIGNOR-55706 |
| MAPKAPK5 | phosphorylation up-regulates → | PLA2G4A PSer727 | phosphorylation up-regulates → | PLA2G4A | 10978317 | SIGNOR-250162 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK3 | phosphorylation → up-regulates | PLA2G4A | SIGNOR-38434 |
| MAPK14 | phosphorylation → up-regulates activity | PLA2G4A | SIGNOR-44673 |
| ERK1/2 | phosphorylation → up-regulates | PLA2G4A | SIGNOR-270192 |
| MKNK1 | phosphorylation → up-regulates activity | PLA2G4A | SIGNOR-226633 |
| PRKCZ | phosphorylation → up-regulates activity | PLA2G4A | SIGNOR-277518 |
| RPS6KA5 | phosphorylation → up-regulates activity | PLA2G4A | SIGNOR-249051 |
| PRKCA | phosphorylation → up-regulates | PLA2G4A | SIGNOR-149406 |
| MAPK1 | phosphorylation → unknown | PLA2G4A | SIGNOR-55706 |
| Gbeta | phosphorylation → up-regulates | PLA2G4A | SIGNOR-270096 |
| MAPKAPK5 | phosphorylation → up-regulates activity | PLA2G4A | SIGNOR-250162 |