| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKC | KCNJ1 | Ser4 | sSRNVFDT | phosphorylation up-regulates activity | 12221079 | SIGNOR-275989 |
| SRC | KCNJ1 | Tyr337 | SKTKEGKyRVDFHNF | phosphorylation down-regulates | 12217858 | SIGNOR-92513 |
| PKC | KCNJ1 | Ser201 | FSKNAVIsKRGGKLC | phosphorylation up-regulates activity | 12221079 | SIGNOR-275990 |
| SRC | KCNJ1 | Tyr337 | SKTKEGKyRVDFHNF | phosphorylation down-regulates | 12556363 | SIGNOR-97803 |
| PRKCA | KCNJ1 | Thr193 | KKRAKTItFSKNAVI | phosphorylation down-regulates activity | 22139477 | SIGNOR-276389 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKC | phosphorylation up-regulates → | KCNJ1 PSer4 | phosphorylation up-regulates → | KCNJ1 | 12221079 | SIGNOR-275989 |
| SRC | phosphorylation up-regulates → | KCNJ1 PTyr337 | phosphorylation down-regulates ⊣ | KCNJ1 | 12217858 | SIGNOR-92513 |
| PKC | phosphorylation up-regulates → | KCNJ1 PSer201 | phosphorylation up-regulates → | KCNJ1 | 12221079 | SIGNOR-275990 |
| SRC | phosphorylation up-regulates → | KCNJ1 PTyr337 | phosphorylation down-regulates ⊣ | KCNJ1 | 12556363 | SIGNOR-97803 |
| PRKCA | phosphorylation up-regulates → | KCNJ1 PThr193 | phosphorylation down-regulates ⊣ | KCNJ1 | 22139477 | SIGNOR-276389 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PKC | phosphorylation → up-regulates activity | KCNJ1 | SIGNOR-275989 |
| SRC | phosphorylation down-regulates | KCNJ1 | SIGNOR-92513 |
| PKC | phosphorylation → up-regulates activity | KCNJ1 | SIGNOR-275990 |
| SRC | phosphorylation down-regulates | KCNJ1 | SIGNOR-97803 |
| PRKCA | phosphorylation → down-regulates activity | KCNJ1 | SIGNOR-276389 |
