| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| NEK1 | ME1 | Ser336 | KKIWLVDsKGLIVKG | phosphorylation down-regulates activity | 31735643 | SIGNOR-275570 |
| PGAM5 | ME1 | Ser336 | KKIWLVDsKGLIVKG | dephosphorylation up-regulates activity | 31735643 | SIGNOR-275569 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| NEK1 | phosphorylation up-regulates → | ME1 PSer336 | phosphorylation down-regulates ⊣ | ME1 | 31735643 | SIGNOR-275570 |
| PGAM5 | dephosphorylation down-regulates ⊣ | ME1 PSer336 | dephosphorylation down-regulates ⊣ | ME1 | 31735643 | SIGNOR-275569 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| NEK1 | phosphorylation → down-regulates activity | ME1 | SIGNOR-275570 |
| PGAM5 | dephosphorylation → up-regulates activity | ME1 | SIGNOR-275569 |
